Acute impact of an endurance race on cardiac function and biomarkers of myocardial injury in triathletes with and without myocardial fibrosis

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Enver Tahir
  • Benedikt Scherz
  • Jitka Starekova
  • Kai Muellerleile
  • Roland Fischer
  • Bjoern Schoennagel
  • Malte Warncke
  • Christian Stehning
  • Ersin Cavus
  • Sebastian Bohnen
  • Ulf K Radunski
  • Stefan Blankenberg
  • Perikles Simon
  • Axel Pressler
  • Gerhard Adam
  • Monica Patten
  • Gunnar K Lund
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000503364300015&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1177/2047487319859975
eISSN
2047-4881
Externe Identifier
  • Clarivate Analytics Document Solution ID: JW9KT
  • PubMed Identifier: 31242053
ISSN
2047-4873
Ausgabe der Veröffentlichung
1
Zeitschrift
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
Schlüsselwörter
  • Athlete's heart
  • cardiac magnetic resonance
  • myocardial fibrosis
  • late gadolinium enhancement
  • T2 and T1 mapping
  • post-race myocardial oedema
  • post-race cardiac function
Paginierung
94 - 104
Datum der Veröffentlichung
2020
Status
Published
Titel
Acute impact of an endurance race on cardiac function and biomarkers of myocardial injury in triathletes with and without myocardial fibrosis
Sub types
  • Article
Ausgabe der Zeitschrift
27

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:sec><jats:title>Aims</jats:title><jats:p> The aim of this study was to investigate the occurrence of myocardial injury and cardiac dysfunction after an endurance race by biomarkers and cardiac magnetic resonance in triathletes with and without myocardial fibrosis. </jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p> Thirty asymptomatic male triathletes (45 ± 10 years) with over 10 training hours per week and 55 ± 8 ml/kg per minute maximal oxygen uptake during exercise testing were studied before (baseline) and 2.4 ± 1.1 hours post-race. Baseline cardiac magnetic resonance included cine, T1/T2, late gadolinium enhancement (LGE) and extracellular volume imaging. Post-race non-contrast cardiac magnetic resonance included cine and T1/T2 mapping. Non-ischaemic myocardial fibrosis was present in 10 triathletes (LGE+) whereas 20 had no fibrosis (LGE–). At baseline, LGE + triathletes had higher peak exercise systolic blood pressure with 222 ± 21 mmHg compared to LGE– triathletes (192 ± 30 mmHg, P &lt; 0.01). Post-race troponin T and creatine kinase MB were similarly increased in both groups, but there was no change in T2 and T1 from baseline to post-race with 54 ± 3 ms versus 53 ± 3 ms ( P = 0.797) and 989 ± 21 ms versus 989 ± 28 ms ( P = 0.926), respectively. However, post-race left atrial ejection fraction was significantly lower in LGE + triathletes compared to LGE– triathletes (53 ± 6% vs. 59 ± 6%, P &lt; 0.05). Furthermore, baseline atrial peak filling rates were lower in LGE –  triathletes (121 ± 30 ml/s/m<jats:sup>2</jats:sup>) compared to LGE + triathletes (161 ± 34 ml/s/m<jats:sup>2</jats:sup>, P &lt; 0.01). Post-race atrial peak filling rates increased in LGE– triathletes to 163 ± 46 ml/s/m<jats:sup>2</jats:sup>, P &lt; 0.001), but not in LGE + triathletes (169 ± 50ml/s/m<jats:sup>2</jats:sup>, P = 0.747). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Despite post-race troponin T release, we did not find detectable myocardial oedema by cardiac magnetic resonance. However, the unfavourable blood pressure response during exercise testing seemed to be associated with post-race cardiac dysfunction, which could explain the occurrence of myocardial fibrosis in triathletes. </jats:p></jats:sec>
Autoren
  • Enver Tahir
  • Benedikt Scherz
  • Jitka Starekova
  • Kai Muellerleile
  • Roland Fischer
  • Björn Schoennagel
  • Malte Warncke
  • Christian Stehning
  • Ersin Cavus
  • Sebastian Bohnen
  • Ulf K Radunski
  • Stefan Blankenberg
  • Perikles Simon
  • Axel Pressler
  • Gerhard Adam
  • Monica Patten
  • Gunnar K Lund
DOI
10.1177/2047487319859975
eISSN
2047-4881
ISSN
2047-4873
Ausgabe der Veröffentlichung
1
Zeitschrift
European Journal of Preventive Cardiology
Sprache
en
Online publication date
2019
Paginierung
94 - 104
Datum der Veröffentlichung
2020
Status
Published
Herausgeber
Oxford University Press (OUP)
Herausgeber URL
http://dx.doi.org/10.1177/2047487319859975
Datum der Datenerfassung
2021
Titel
Acute impact of an endurance race on cardiac function and biomarkers of myocardial injury in triathletes with and without myocardial fibrosis
Ausgabe der Zeitschrift
27

Datenquelle: Crossref

Abstract
<h4>Aims</h4>The aim of this study was to investigate the occurrence of myocardial injury and cardiac dysfunction after an endurance race by biomarkers and cardiac magnetic resonance in triathletes with and without myocardial fibrosis.<h4>Methods and results</h4>Thirty asymptomatic male triathletes (45 ± 10 years) with over 10 training hours per week and 55 ± 8 ml/kg per minute maximal oxygen uptake during exercise testing were studied before (baseline) and 2.4 ± 1.1 hours post-race. Baseline cardiac magnetic resonance included cine, T1/T2, late gadolinium enhancement (LGE) and extracellular volume imaging. Post-race non-contrast cardiac magnetic resonance included cine and T1/T2 mapping. Non-ischaemic myocardial fibrosis was present in 10 triathletes (LGE+) whereas 20 had no fibrosis (LGE-). At baseline, LGE + triathletes had higher peak exercise systolic blood pressure with 222 ± 21 mmHg compared to LGE- triathletes (192 ± 30 mmHg, <i>P</i> < 0.01). Post-race troponin T and creatine kinase MB were similarly increased in both groups, but there was no change in T2 and T1 from baseline to post-race with 54 ± 3 ms versus 53 ± 3 ms (<i>P</i> = 0.797) and 989 ± 21 ms versus 989 ± 28 ms (<i>P</i> = 0.926), respectively. However, post-race left atrial ejection fraction was significantly lower in LGE + triathletes compared to LGE- triathletes (53 ± 6% vs. 59 ± 6%, <i>P</i> < 0.05). Furthermore, baseline atrial peak filling rates were lower in LGE -  triathletes (121 ± 30 ml/s/m<sup>2</sup>) compared to LGE + triathletes (161 ± 34 ml/s/m<sup>2</sup>, <i>P</i> < 0.01). Post-race atrial peak filling rates increased in LGE- triathletes to 163 ± 46 ml/s/m<sup>2</sup>, <i>P</i> < 0.001), but not in LGE + triathletes (169 ± 50ml/s/m<sup>2</sup>, <i>P</i> = 0.747).<h4>Conclusion</h4>Despite post-race troponin T release, we did not find detectable myocardial oedema by cardiac magnetic resonance. However, the unfavourable blood pressure response during exercise testing seemed to be associated with post-race cardiac dysfunction, which could explain the occurrence of myocardial fibrosis in triathletes.
Addresses
  • Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Hospital Hamburg-Eppendorf, Germany.
Autoren
  • Enver Tahir
  • Benedikt Scherz
  • Jitka Starekova
  • Kai Muellerleile
  • Roland Fischer
  • Björn Schoennagel
  • Malte Warncke
  • Christian Stehning
  • Ersin Cavus
  • Sebastian Bohnen
  • Ulf K Radunski
  • Stefan Blankenberg
  • Perikles Simon
  • Axel Pressler
  • Gerhard Adam
  • Monica Patten
  • Gunnar K Lund
DOI
10.1177/2047487319859975
eISSN
2047-4881
Externe Identifier
  • PubMed Identifier: 31242053
  • PubMed Central ID: PMC6923712
Open access
true
ISSN
2047-4873
Ausgabe der Veröffentlichung
1
Zeitschrift
European journal of preventive cardiology
Schlüsselwörter
  • Myocardium
  • Humans
  • Cardiomyopathies
  • Edema, Cardiac
  • Fibrosis
  • Troponin T
  • Magnetic Resonance Imaging, Cine
  • Case-Control Studies
  • Predictive Value of Tests
  • Blood Pressure
  • Ventricular Function, Left
  • Ventricular Function, Right
  • Physical Endurance
  • Running
  • Swimming
  • Time Factors
  • Bicycling
  • Adolescent
  • Adult
  • Middle Aged
  • Male
  • Creatine Kinase, MB Form
  • Young Adult
  • Biomarkers
Sprache
eng
Medium
Print-Electronic
Online publication date
2019
Open access status
Open Access
Paginierung
94 - 104
Datum der Veröffentlichung
2020
Status
Published
Publisher licence
CC BY-NC
Datum der Datenerfassung
2019
Titel
Acute impact of an endurance race on cardiac function and biomarkers of myocardial injury in triathletes with and without myocardial fibrosis.
Sub types
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
27

Files

https://watermark.silverchair.com/eurjpc0094.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAqswggKnBgkqhkiG9w0BBwagggKYMIIClAIBADCCAo0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMFvSOFshPogC2DcFIAgEQgIICXnG5iNL7bwmj5hCP0ghExAIlQX-ryYiw4obOezkhseZwHfvbbr7Aif9P7FqS167azZitxqeXeEKtI74lt8AyuPfUKbm0nKXkzSzqw726ZLIyEi0mplbsZ3A-gveP2WeWocjyeVpjDdOJHS8ilIEtKliUniyfvjaaPY4Xip2UTNHZND-vGLs-UTnLZiChd https://europepmc.org/articles/PMC6923712?pdf=render

Datenquelle: Europe PubMed Central

Abstract
AIMS: The aim of this study was to investigate the occurrence of myocardial injury and cardiac dysfunction after an endurance race by biomarkers and cardiac magnetic resonance in triathletes with and without myocardial fibrosis. METHODS AND RESULTS: Thirty asymptomatic male triathletes (45 ± 10 years) with over 10 training hours per week and 55 ± 8 ml/kg per minute maximal oxygen uptake during exercise testing were studied before (baseline) and 2.4 ± 1.1 hours post-race. Baseline cardiac magnetic resonance included cine, T1/T2, late gadolinium enhancement (LGE) and extracellular volume imaging. Post-race non-contrast cardiac magnetic resonance included cine and T1/T2 mapping. Non-ischaemic myocardial fibrosis was present in 10 triathletes (LGE+) whereas 20 had no fibrosis (LGE-). At baseline, LGE + triathletes had higher peak exercise systolic blood pressure with 222 ± 21 mmHg compared to LGE- triathletes (192 ± 30 mmHg, P < 0.01). Post-race troponin T and creatine kinase MB were similarly increased in both groups, but there was no change in T2 and T1 from baseline to post-race with 54 ± 3 ms versus 53 ± 3 ms (P = 0.797) and 989 ± 21 ms versus 989 ± 28 ms (P = 0.926), respectively. However, post-race left atrial ejection fraction was significantly lower in LGE + triathletes compared to LGE- triathletes (53 ± 6% vs. 59 ± 6%, P < 0.05). Furthermore, baseline atrial peak filling rates were lower in LGE -  triathletes (121 ± 30 ml/s/m2) compared to LGE + triathletes (161 ± 34 ml/s/m2, P < 0.01). Post-race atrial peak filling rates increased in LGE- triathletes to 163 ± 46 ml/s/m2, P < 0.001), but not in LGE + triathletes (169 ± 50ml/s/m2, P = 0.747). CONCLUSION: Despite post-race troponin T release, we did not find detectable myocardial oedema by cardiac magnetic resonance. However, the unfavourable blood pressure response during exercise testing seemed to be associated with post-race cardiac dysfunction, which could explain the occurrence of myocardial fibrosis in triathletes.
Autoren
  • Enver Tahir
  • Benedikt Scherz
  • Jitka Starekova
  • Kai Muellerleile
  • Roland Fischer
  • Björn Schoennagel
  • Malte Warncke
  • Christian Stehning
  • Ersin Cavus
  • Sebastian Bohnen
  • Ulf K Radunski
  • Stefan Blankenberg
  • Perikles Simon
  • Axel Pressler
  • Gerhard Adam
  • Monica Patten
  • Gunnar K Lund
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/31242053
DOI
10.1177/2047487319859975
eISSN
2047-4881
Externe Identifier
  • PubMed Central ID: PMC6923712
Ausgabe der Veröffentlichung
1
Zeitschrift
Eur J Prev Cardiol
Schlüsselwörter
  • Athlete's heart
  • T2 and T1 mapping
  • cardiac magnetic resonance
  • late gadolinium enhancement
  • myocardial fibrosis
  • post-race cardiac function
  • post-race myocardial oedema
  • Adolescent
  • Adult
  • Bicycling
  • Biomarkers
  • Blood Pressure
  • Cardiomyopathies
  • Case-Control Studies
  • Creatine Kinase, MB Form
  • Edema, Cardiac
  • Fibrosis
  • Humans
  • Magnetic Resonance Imaging, Cine
  • Male
  • Middle Aged
  • Myocardium
  • Physical Endurance
  • Predictive Value of Tests
  • Running
  • Swimming
  • Time Factors
  • Troponin T
  • Ventricular Function, Left
  • Ventricular Function, Right
  • Young Adult
Sprache
eng
Country
England
Paginierung
94 - 104
Datum der Veröffentlichung
2020
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Titel
Acute impact of an endurance race on cardiac function and biomarkers of myocardial injury in triathletes with and without myocardial fibrosis.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
27

Datenquelle: PubMed

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