The Snoring Index Identifies Risk of Non-Alcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea Syndrome
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Katharina Bahr
- Perikles Simon
- Barbara Leggewie
- Haralampos Gouveris
- Joern Schattenberg
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000746140400001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/biology11010010
- eISSN
- 2079-7737
- Externe Identifier
- Clarivate Analytics Document Solution ID: YL8MA
- PubMed Identifier: 35053008
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- BIOLOGY-BASEL
- Schlüsselwörter
- obstructive sleep apnea
- non-alcoholic fatty liver disease
- AHI
- snoring
- CAP
- transient elastography
- Artikelnummer
- ARTN 10
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- The Snoring Index Identifies Risk of Non-Alcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea Syndrome
- Sub types
- Article
- Ausgabe der Zeitschrift
- 11
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>Background: The aim of this observational cohort study was to explore the severity of liver disease in patients with suspected obstructive sleep apnea in Germany. Methods: Patients undergoing polysomnography or home sleep apnea testing (HSAT) as an evaluation for the presence of OSA were screened using vibration-controlled transient elastography (VCTE) and continuous attenuation parameter (CAP) with a Fibroscan ® Mini 430. Clinical and laboratory data were collected following the overnight exam. Results: In total, 78 patients (28 female (35.9%), mean age 54.2 years) with OSA defined by an apnea-hypopnea-index >5 events/hour were included between OCT 2020 and APR 2021. Patients exhibited a high metabolic risk profile with 17% known diabetes mellitus type 2 (T2D), 62% arterial hypertension, 14% hyperlipidemia and 36% BMI > 30 kg/m2. The prevalence of steatosis defined by a CAP > 280 dB/m was 54%. The prevalence of at least significant fibrosis was 16% (E > 9.0 kPa). Interestingly, patients with a snoring index above the median of 278/h showed significantly higher CAP-values (p = 0.0002). In addition, the proportion of oxygen saturations below 90% (t90) correlated with CAP-values (p = 0.02), as well as metabolic risk factors including increased waist circumference (p = 0.005) and body mass index (BMI) (p = 0.035). On the other hand, the apnea-hypopnea-index (AHI) as a marker of OSA severity did not correlate with VCTE, CAP or laboratory parameters. Conclusion: Patients with moderate to severe OSA have a high prevalence of hepatic steatosis. The snoring index is an easy-to-use clinical tool to identify patients at risk for relevant liver disease within the larger group of patients with OSA.</jats:p>
- Autoren
- Katharina Bahr
- Perikles Simon
- Barbara Leggewie
- Haralampos Gouveris
- Jörn Schattenberg
- DOI
- 10.3390/biology11010010
- eISSN
- 2079-7737
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Biology
- Sprache
- en
- Online publication date
- 2021
- Paginierung
- 10 - 10
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/biology11010010
- Datum der Datenerfassung
- 2021
- Titel
- The Snoring Index Identifies Risk of Non-Alcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea Syndrome
- Ausgabe der Zeitschrift
- 11
Datenquelle: Crossref
- Abstract
- <h4>Background</h4>The aim of this observational cohort study was to explore the severity of liver disease in patients with suspected obstructive sleep apnea in Germany.<h4>Methods</h4>Patients undergoing polysomnography or home sleep apnea testing (HSAT) as an evaluation for the presence of OSA were screened using vibration-controlled transient elastography (VCTE) and continuous attenuation parameter (CAP) with a Fibroscan ® Mini 430. Clinical and laboratory data were collected following the overnight exam.<h4>Results</h4>In total, 78 patients (28 female (35.9%), mean age 54.2 years) with OSA defined by an apnea-hypopnea-index >5 events/hour were included between OCT 2020 and APR 2021. Patients exhibited a high metabolic risk profile with 17% known diabetes mellitus type 2 (T2D), 62% arterial hypertension, 14% hyperlipidemia and 36% BMI > 30 kg/m<sup>2</sup>. The prevalence of steatosis defined by a CAP > 280 dB/m was 54%. The prevalence of at least significant fibrosis was 16% (E > 9.0 kPa). Interestingly, patients with a snoring index above the median of 278/h showed significantly higher CAP-values (<i>p</i> = 0.0002). In addition, the proportion of oxygen saturations below 90% (t90) correlated with CAP-values (<i>p</i> = 0.02), as well as metabolic risk factors including increased waist circumference (<i>p</i> = 0.005) and body mass index (BMI) (<i>p</i> = 0.035). On the other hand, the apnea-hypopnea-index (AHI) as a marker of OSA severity did not correlate with VCTE, CAP or laboratory parameters.<h4>Conclusion</h4>Patients with moderate to severe OSA have a high prevalence of hepatic steatosis. The snoring index is an easy-to-use clinical tool to identify patients at risk for relevant liver disease within the larger group of patients with OSA.
- Addresses
- Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany.
- Autoren
- Katharina Bahr
- Perikles Simon
- Barbara Leggewie
- Haralampos Gouveris
- Jörn Schattenberg
- DOI
- 10.3390/biology11010010
- eISSN
- 2079-7737
- Externe Identifier
- PubMed Identifier: 35053008
- PubMed Central ID: PMC8772878
- Open access
- true
- ISSN
- 2079-7737
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Biology
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2021
- Open access status
- Open Access
- Paginierung
- 10
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2022
- Titel
- The Snoring Index Identifies Risk of Non-Alcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea Syndrome.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 11
Files
https://www.mdpi.com/2079-7737/11/1/10/pdf?version=1640230465 https://europepmc.org/articles/PMC8772878?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- BACKGROUND: The aim of this observational cohort study was to explore the severity of liver disease in patients with suspected obstructive sleep apnea in Germany. METHODS: Patients undergoing polysomnography or home sleep apnea testing (HSAT) as an evaluation for the presence of OSA were screened using vibration-controlled transient elastography (VCTE) and continuous attenuation parameter (CAP) with a Fibroscan ® Mini 430. Clinical and laboratory data were collected following the overnight exam. RESULTS: In total, 78 patients (28 female (35.9%), mean age 54.2 years) with OSA defined by an apnea-hypopnea-index >5 events/hour were included between OCT 2020 and APR 2021. Patients exhibited a high metabolic risk profile with 17% known diabetes mellitus type 2 (T2D), 62% arterial hypertension, 14% hyperlipidemia and 36% BMI > 30 kg/m2. The prevalence of steatosis defined by a CAP > 280 dB/m was 54%. The prevalence of at least significant fibrosis was 16% (E > 9.0 kPa). Interestingly, patients with a snoring index above the median of 278/h showed significantly higher CAP-values (p = 0.0002). In addition, the proportion of oxygen saturations below 90% (t90) correlated with CAP-values (p = 0.02), as well as metabolic risk factors including increased waist circumference (p = 0.005) and body mass index (BMI) (p = 0.035). On the other hand, the apnea-hypopnea-index (AHI) as a marker of OSA severity did not correlate with VCTE, CAP or laboratory parameters. CONCLUSION: Patients with moderate to severe OSA have a high prevalence of hepatic steatosis. The snoring index is an easy-to-use clinical tool to identify patients at risk for relevant liver disease within the larger group of patients with OSA.
- Date of acceptance
- 2021
- Autoren
- Katharina Bahr
- Perikles Simon
- Barbara Leggewie
- Haralampos Gouveris
- Jörn Schattenberg
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/35053008
- DOI
- 10.3390/biology11010010
- Externe Identifier
- PubMed Central ID: PMC8772878
- ISSN
- 2079-7737
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Biology (Basel)
- Schlüsselwörter
- AHI
- CAP
- non-alcoholic fatty liver disease
- obstructive sleep apnea
- snoring
- transient elastography
- Sprache
- eng
- Country
- Switzerland
- PII
- biology11010010
- Datum der Veröffentlichung
- 2021
- Status
- Published online
- Titel
- The Snoring Index Identifies Risk of Non-Alcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea Syndrome.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 11
Datenquelle: PubMed
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