Extracts of Rheum palmatum and Aloe vera Show Beneficial Properties for the Synergistic Improvement of Oral Wound Healing
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Lena Katharina Mueller-Heupt
- Nadine Wiesmann
- Sofia Schroeder
- Yueksel Korkmaz
- Nina Vierengel
- Jonathan Gross
- Rolf Dahm
- James Deschner
- Till Opatz
- Juergen Brieger
- Bilal Al-Nawas
- Peer W Kaemmerer
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000873503000001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/pharmaceutics14102060
- eISSN
- 1999-4923
- Externe Identifier
- Clarivate Analytics Document Solution ID: 5Q0AL
- PubMed Identifier: 36297494
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- PHARMACEUTICS
- Schlüsselwörter
- Aloe vera
- broth microdilution
- fibroblasts
- phenomenological combination index
- Porphyromonas gingivalis
- promigratoy effect
- Rheum palmatum root extract
- scratch assay
- synergy
- wound healing
- Artikelnummer
- ARTN 2060
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Extracts of <i>Rheum palmatum</i> and <i>Aloe vera</i> Show Beneficial Properties for the Synergistic Improvement of Oral Wound Healing
- Sub types
- Article
- Ausgabe der Zeitschrift
- 14
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>Various local and systemic factors compromise oral wound healing and may lead to wound dehiscence, inflammation, or ulcers. Currently, there is a lack of topical therapeutical options. Thus, this study aimed to investigate the effect of Aloe vera (AV) and Rheum palmatum root (RPR) on oral wound healing capacity in vitro. The effect of AV and RPR on human primary fibroblast viability and migration was studied by measuring metabolic activity and gap closure in a scratch assay. Furthermore, cell cycle distribution and cytoskeletal features were analyzed. Antimicrobial activity against the oral pathogen Porphyromonas gingivalis was evaluated by broth microdilution assay. AV and RPR increased fibroblast migration after single agent treatment. Synergistic effects of the plant extract combination were observed regarding cellular migration which were confirmed by calculation of the phenomenological combination index (pCI), whereas the cell cycle distribution was not influenced. Furthermore, the combination of AV and RPR showed synergistic antibacterial effects as determined by the fractional inhibitory concentration index. This study demonstrated that the combination of AV and RPR can promote the migration of human primary fibroblasts in vitro and exert antimicrobial efficacy against P. gingivalis, suggesting these compounds for the topical treatment of wound healing disorders.</jats:p>
- Autoren
- Lena Katharina Müller-Heupt
- Nadine Wiesmann
- Sofia Schröder
- Yüksel Korkmaz
- Nina Vierengel
- Jonathan Groß
- Rolf Dahm
- James Deschner
- Till Opatz
- Juergen Brieger
- Bilal Al-Nawas
- Peer W Kämmerer
- DOI
- 10.3390/pharmaceutics14102060
- eISSN
- 1999-4923
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Pharmaceutics
- Sprache
- en
- Online publication date
- 2022
- Paginierung
- 2060 - 2060
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/pharmaceutics14102060
- Datum der Datenerfassung
- 2022
- Titel
- Extracts of Rheum palmatum and Aloe vera Show Beneficial Properties for the Synergistic Improvement of Oral Wound Healing
- Ausgabe der Zeitschrift
- 14
Datenquelle: Crossref
- Abstract
- Various local and systemic factors compromise oral wound healing and may lead to wound dehiscence, inflammation, or ulcers. Currently, there is a lack of topical therapeutical options. Thus, this study aimed to investigate the effect of <i>Aloe vera</i> (AV) and <i>Rheum palmatum</i> root (RPR) on oral wound healing capacity in vitro. The effect of AV and RPR on human primary fibroblast viability and migration was studied by measuring metabolic activity and gap closure in a scratch assay. Furthermore, cell cycle distribution and cytoskeletal features were analyzed. Antimicrobial activity against the oral pathogen <i>Porphyromonas gingivalis</i> was evaluated by broth microdilution assay. AV and RPR increased fibroblast migration after single agent treatment. Synergistic effects of the plant extract combination were observed regarding cellular migration which were confirmed by calculation of the phenomenological combination index (pCI), whereas the cell cycle distribution was not influenced. Furthermore, the combination of AV and RPR showed synergistic antibacterial effects as determined by the fractional inhibitory concentration index. This study demonstrated that the combination of AV and RPR can promote the migration of human primary fibroblasts in vitro and exert antimicrobial efficacy against <i>P. gingivalis</i>, suggesting these compounds for the topical treatment of wound healing disorders.
- Addresses
- Department of Oral- and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, 55131 Mainz, Germany.
- Autoren
- Lena Katharina Müller-Heupt
- Nadine Wiesmann
- Sofia Schröder
- Yüksel Korkmaz
- Nina Vierengel
- Jonathan Groß
- Rolf Dahm
- James Deschner
- Till Opatz
- Juergen Brieger
- Bilal Al-Nawas
- Peer W Kämmerer
- DOI
- 10.3390/pharmaceutics14102060
- eISSN
- 1999-4923
- Externe Identifier
- PubMed Identifier: 36297494
- PubMed Central ID: PMC9610717
- Funding acknowledgements
- Ministry of Economic Affairs, Rhineland-Palatinate: Startup Innovativ
- Open access
- true
- ISSN
- 1999-4923
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Pharmaceutics
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2022
- Open access status
- Open Access
- Paginierung
- 2060
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2022
- Titel
- Extracts of <i>Rheum palmatum</i> and <i>Aloe vera</i> Show Beneficial Properties for the Synergistic Improvement of Oral Wound Healing.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 14
Files
https://www.mdpi.com/1999-4923/14/10/2060/pdf?version=1664280344 https://europepmc.org/articles/PMC9610717?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Various local and systemic factors compromise oral wound healing and may lead to wound dehiscence, inflammation, or ulcers. Currently, there is a lack of topical therapeutical options. Thus, this study aimed to investigate the effect of Aloe vera (AV) and Rheum palmatum root (RPR) on oral wound healing capacity in vitro. The effect of AV and RPR on human primary fibroblast viability and migration was studied by measuring metabolic activity and gap closure in a scratch assay. Furthermore, cell cycle distribution and cytoskeletal features were analyzed. Antimicrobial activity against the oral pathogen Porphyromonas gingivalis was evaluated by broth microdilution assay. AV and RPR increased fibroblast migration after single agent treatment. Synergistic effects of the plant extract combination were observed regarding cellular migration which were confirmed by calculation of the phenomenological combination index (pCI), whereas the cell cycle distribution was not influenced. Furthermore, the combination of AV and RPR showed synergistic antibacterial effects as determined by the fractional inhibitory concentration index. This study demonstrated that the combination of AV and RPR can promote the migration of human primary fibroblasts in vitro and exert antimicrobial efficacy against P. gingivalis, suggesting these compounds for the topical treatment of wound healing disorders.
- Date of acceptance
- 2022
- Autoren
- Lena Katharina Müller-Heupt
- Nadine Wiesmann
- Sofia Schröder
- Yüksel Korkmaz
- Nina Vierengel
- Jonathan Groß
- Rolf Dahm
- James Deschner
- Till Opatz
- Juergen Brieger
- Bilal Al-Nawas
- Peer W Kämmerer
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/36297494
- DOI
- 10.3390/pharmaceutics14102060
- Externe Identifier
- PubMed Central ID: PMC9610717
- Funding acknowledgements
- Ministry of Economic Affairs, Rhineland-Palatinate: Startup Innovativ
- ISSN
- 1999-4923
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Pharmaceutics
- Schlüsselwörter
- Aloe vera
- Porphyromonas gingivalis
- Rheum palmatum root extract
- broth microdilution
- fibroblasts
- phenomenological combination index
- promigratoy effect
- scratch assay
- synergy
- wound healing
- Sprache
- eng
- Country
- Switzerland
- PII
- pharmaceutics14102060
- Datum der Veröffentlichung
- 2022
- Status
- Published online
- Titel
- Extracts of Rheum palmatum and Aloe vera Show Beneficial Properties for the Synergistic Improvement of Oral Wound Healing.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 14
Datenquelle: PubMed
- Author's licence
- CC-BY
- Autoren
- Lena Katharina Müller-Heupt
- Nadine Wiesmann
- Sofia Schröder
- Yüksel Korkmaz
- Nina Vierengel
- Jonathan Groß
- Rolf Dahm
- James Deschner
- Till Opatz
- Juergen Brieger
- Bilal Al-Nawas
- Peer W Kämmerer
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- DFG-491381577-G
- Resource version
- Published version
- DOI
- 10.3390/pharmaceutics14102060
- Funding acknowledgements
- Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 1999-4923
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Pharmaceutics
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 2060
- Datum der Veröffentlichung
- 2022
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/8628
- Herausgeber
- MDPI
- Datum der Datenerfassung
- 2023
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2023
- Zugang
- Public
- Titel
- Extracts of Rheum palmatum and Aloe vera show beneficial properties for the synergistic improvement of oral wound healing
- Ausgabe der Zeitschrift
- 14
Files
extracts_of_rheum_palmatum_an-20230119112914106.pdf
Datenquelle: OPENSCIENCE.UB
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