Biogenic Guanine Crystals Are Solid Solutions of Guanine and OtherPurine Metabolites
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Noam Pinsk
- Avital Wagner
- Lilian Cohen
- Christopher JH Smalley
- Colan E Hughes
- Gan Zhang
- Mariela J Pavan
- Nicola Casati
- Anne Jantschke
- Gil Goobes
- Kenneth DM Harris
- Benjamin A Palmer
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000777169400054&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1021/jacs.2c00724
- eISSN
- 1520-5126
- Externe Identifier
- Clarivate Analytics Document Solution ID: 0F2AZ
- PubMed Identifier: 35255213
- ISSN
- 0002-7863
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Paginierung
- 5180 - 5189
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Biogenic Guanine Crystals Are Solid Solutions of Guanine and OtherPurine Metabolites
- Sub types
- Article
- Ausgabe der Zeitschrift
- 144
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Noam Pinsk
- Avital Wagner
- Lilian Cohen
- Christopher JH Smalley
- Colan E Hughes
- Gan Zhang
- Mariela J Pavan
- Nicola Casati
- Anne Jantschke
- Gil Goobes
- Kenneth DM Harris
- Benjamin A Palmer
- DOI
- 10.1021/jacs.2c00724
- eISSN
- 1520-5126
- ISSN
- 0002-7863
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- Journal of the American Chemical Society
- Sprache
- en
- Online publication date
- 2022
- Paginierung
- 5180 - 5189
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Herausgeber
- American Chemical Society (ACS)
- Herausgeber URL
- http://dx.doi.org/10.1021/jacs.2c00724
- Datum der Datenerfassung
- 2023
- Titel
- Biogenic Guanine Crystals Are Solid Solutions of Guanine and Other Purine Metabolites
- Ausgabe der Zeitschrift
- 144
Datenquelle: Crossref
- Abstract
- Highly reflective crystals of the nucleotide base guanine are widely distributed in animal coloration and visual systems. Organisms precisely control the morphology and organization of the crystals to optimize different optical effects, but little is known about how this is achieved. Here we examine a fundamental question that has remained unanswered after over 100 years of research on guanine: <i>what are the crystals made of</i>? Using solution-state and solid-state chemical techniques coupled with structural analysis by powder XRD and solid-state NMR, we compare the purine compositions and the structures of seven biogenic guanine crystals with different crystal morphologies, testing the hypothesis that intracrystalline dopants influence the crystal shape. We find that biogenic "guanine" crystals are not pure crystals but <i>molecular alloys</i> (aka solid solutions and mixed crystals) of guanine, hypoxanthine, and sometimes xanthine. Guanine host crystals occlude homogeneous mixtures of other purines, sometimes in remarkably large amounts (up to 20% of hypoxanthine), without significantly altering the crystal structure of the guanine host. We find no correlation between the biogenic crystal morphology and dopant content and conclude that dopants do not dictate the crystal morphology of the guanine host. The ability of guanine crystals to host other molecules enables animals to build physiologically "cheaper" crystals from mixtures of metabolically available purines, without impeding optical functionality. The exceptional levels of doping in biogenic guanine offer inspiration for the design of mixed molecular crystals that incorporate multiple functionalities in a single material.
- Addresses
- Department of Chemistry, Ben-Gurion University of the Negev, Be'er Sheba 8410501, Israel.
- Autoren
- Noam Pinsk
- Avital Wagner
- Lilian Cohen
- Christopher JH Smalley
- Colan E Hughes
- Gan Zhang
- Mariela J Pavan
- Nicola Casati
- Anne Jantschke
- Gil Goobes
- Kenneth DM Harris
- Benjamin A Palmer
- DOI
- 10.1021/jacs.2c00724
- eISSN
- 1520-5126
- Externe Identifier
- PubMed Identifier: 35255213
- PubMed Central ID: PMC8949762
- Funding acknowledgements
- European Research Council: 852948
- Open access
- true
- ISSN
- 0002-7863
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- Journal of the American Chemical Society
- Schlüsselwörter
- Animals
- Purines
- Guanine
- Hypoxanthine
- Xanthine
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2022
- Open access status
- Open Access
- Paginierung
- 5180 - 5189
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Publisher licence
- CC BY-NC-ND
- Datum der Datenerfassung
- 2022
- Titel
- Biogenic Guanine Crystals Are Solid Solutions of Guanine and Other Purine Metabolites.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 144
Files
https://www.dora.lib4ri.ch/psi/islandora/object/psi%3A41322/datastream/PDF/Pinsk-2022-Biogenic_guanine_crystals_are_solid-%28published_version%29.pdf https://europepmc.org/articles/PMC8949762?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Highly reflective crystals of the nucleotide base guanine are widely distributed in animal coloration and visual systems. Organisms precisely control the morphology and organization of the crystals to optimize different optical effects, but little is known about how this is achieved. Here we examine a fundamental question that has remained unanswered after over 100 years of research on guanine: what are the crystals made of? Using solution-state and solid-state chemical techniques coupled with structural analysis by powder XRD and solid-state NMR, we compare the purine compositions and the structures of seven biogenic guanine crystals with different crystal morphologies, testing the hypothesis that intracrystalline dopants influence the crystal shape. We find that biogenic "guanine" crystals are not pure crystals but molecular alloys (aka solid solutions and mixed crystals) of guanine, hypoxanthine, and sometimes xanthine. Guanine host crystals occlude homogeneous mixtures of other purines, sometimes in remarkably large amounts (up to 20% of hypoxanthine), without significantly altering the crystal structure of the guanine host. We find no correlation between the biogenic crystal morphology and dopant content and conclude that dopants do not dictate the crystal morphology of the guanine host. The ability of guanine crystals to host other molecules enables animals to build physiologically "cheaper" crystals from mixtures of metabolically available purines, without impeding optical functionality. The exceptional levels of doping in biogenic guanine offer inspiration for the design of mixed molecular crystals that incorporate multiple functionalities in a single material.
- Autoren
- Noam Pinsk
- Avital Wagner
- Lilian Cohen
- Christopher JH Smalley
- Colan E Hughes
- Gan Zhang
- Mariela J Pavan
- Nicola Casati
- Anne Jantschke
- Gil Goobes
- Kenneth DM Harris
- Benjamin A Palmer
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/35255213
- DOI
- 10.1021/jacs.2c00724
- eISSN
- 1520-5126
- Externe Identifier
- PubMed Central ID: PMC8949762
- Ausgabe der Veröffentlichung
- 11
- Zeitschrift
- J Am Chem Soc
- Schlüsselwörter
- Animals
- Guanine
- Hypoxanthine
- Purines
- Xanthine
- Sprache
- eng
- Country
- United States
- Paginierung
- 5180 - 5189
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Biogenic Guanine Crystals Are Solid Solutions of Guanine and Other Purine Metabolites.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 144
Datenquelle: PubMed
- Beziehungen:
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