Boron Determination in Liver Tissue by Combining Quantitative Neutron Capture Radiography (QNCR) and Histological Analysis for BNCT Treatment Planning at the TRIGA Mainz

Autoren

C Schütz
C Brochhausen
S Altieri
K Bartholomew
S Bortolussi
F Enzmann
D Gabel
G Hampel
CJ Kirkpatrick
JV Kratz
S Minouchehr
H Schmidberger
G Otto

DOI

10.1667/rr2543.1

eISSN

1938-5404

ISSN

0033-7587

Ausgabe der Veröffentlichung

3

Zeitschrift

Radiation Research

Sprache

en

Paginierung

388 - 396

Datum der Veröffentlichung

2011

Status

Published

Herausgeber

Radiation Research Society

Herausgeber URL

http://dx.doi.org/10.1667/rr2543.1

Datum der Datenerfassung

2017

Titel

Boron Determination in Liver Tissue by Combining Quantitative Neutron Capture Radiography (QNCR) and Histological Analysis for BNCT Treatment Planning at the TRIGA Mainz

Ausgabe der Zeitschrift

176

Datenquelle: Crossref

Abstract

The typical primary malignancies of the liver are hepatocellular carcinoma and cholangiocarcinoma, whereas colorectal liver metastases are the most frequently occurring secondary tumors. In many cases, only palliative treatment is possible. Boron neutron capture therapy (BNCT) represents a technique that potentially destroys tumor tissue selectively by use of externally induced, locally confined secondary particle irradiation. In 2001 and 2003, BNCT was applied to two patients with colorectal liver metastases in Pavia, Italy. To scrutinize the rationale of BNCT, a clinical pilot study on patients with colorectal liver metastases was carried out at the University of Mainz. The distribution of the (10)B carrier (p-borono-phenylalanine) in the liver and its uptake in cancerous and tumor-free tissue were determined, focusing on a potential correlation between the uptake of p-borono-phenylalanine and the biological characteristics of cancerous tissue. Samples were analyzed using quantitative neutron capture radiography of cryosections combined with histological analysis. Methodological aspects of the combination of these techniques and results from four patients enrolled in the study are presented that indicate that the uptake of p-borono-phenylalanine strongly depends on the metabolic activity of cells.

Addresses

Institute for Nuclear Chemistry, University of Mainz, Fritz-Strassmann-Weg 2, D-55099 Mainz, Germany. schuetc@uni-mainz.de

Autoren

C Schütz
C Brochhausen
S Altieri
K Bartholomew
S Bortolussi
F Enzmann
D Gabel
G Hampel
CJ Kirkpatrick
JV Kratz
S Minouchehr
H Schmidberger
G Otto

DOI

10.1667/rr2543.1

eISSN

1938-5404

Externe Identifier

PubMed Identifier: 21692653

Open access

false

ISSN

0033-7587

Ausgabe der Veröffentlichung

3

Zeitschrift

Radiation research

Schlüsselwörter

Liver
Cell Line, Tumor
Humans
Boron
Radiography
Neutrons

Sprache

eng

Medium

Print-Electronic

Online publication date

2011

Paginierung

388 - 396

Datum der Veröffentlichung

2011

Status

Published

Datum der Datenerfassung

2011

Titel

Boron determination in liver tissue by combining quantitative neutron capture radiography (QNCR) and histological analysis for BNCT treatment planning at the TRIGA Mainz.

Sub types

Research Support, Non-U.S. Gov't
Journal Article

Ausgabe der Zeitschrift

176

Datenquelle: Europe PubMed Central

Abstract

The typical primary malignancies of the liver are hepatocellular carcinoma and cholangiocarcinoma, whereas colorectal liver metastases are the most frequently occurring secondary tumors. In many cases, only palliative treatment is possible. Boron neutron capture therapy (BNCT) represents a technique that potentially destroys tumor tissue selectively by use of externally induced, locally confined secondary particle irradiation. In 2001 and 2003, BNCT was applied to two patients with colorectal liver metastases in Pavia, Italy. To scrutinize the rationale of BNCT, a clinical pilot study on patients with colorectal liver metastases was carried out at the University of Mainz. The distribution of the (10)B carrier (p-borono-phenylalanine) in the liver and its uptake in cancerous and tumor-free tissue were determined, focusing on a potential correlation between the uptake of p-borono-phenylalanine and the biological characteristics of cancerous tissue. Samples were analyzed using quantitative neutron capture radiography of cryosections combined with histological analysis. Methodological aspects of the combination of these techniques and results from four patients enrolled in the study are presented that indicate that the uptake of p-borono-phenylalanine strongly depends on the metabolic activity of cells.

Autoren

C Schütz
C Brochhausen
S Altieri
K Bartholomew
S Bortolussi
F Enzmann
D Gabel
G Hampel
CJ Kirkpatrick
JV Kratz
S Minouchehr
H Schmidberger
G Otto

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/21692653

DOI

10.1667/rr2543.1

eISSN

1938-5404

Ausgabe der Veröffentlichung

3

Zeitschrift

Radiat Res

Schlüsselwörter

Boron
Cell Line, Tumor
Humans
Liver
Neutrons
Radiography

Sprache

eng

Country

United States

Paginierung

388 - 396

PII

10.1667/RR2543.1

Datum der Veröffentlichung

2011

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2011

Titel

Boron determination in liver tissue by combining quantitative neutron capture radiography (QNCR) and histological analysis for BNCT treatment planning at the TRIGA Mainz.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

176

Datenquelle: PubMed

Boron Determination in Liver Tissue by Combining Quantitative Neutron Capture Radiography (QNCR) and Histological Analysis for BNCT Treatment Planning at the TRIGA Mainz

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