Mortality risk among 5‐year survivors of childhood cancer in Germany—Results from the CVSS study (Cardiac and Vascular late Sequelae in long‐term Survivors of childhood cancer study)

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Abstract
<jats:title>Abstract</jats:title><jats:p>The growing population of long‐term childhood cancer survivors is at increased risk for severe, therapy‐related late effects and premature mortality. The cardiac and vascular late sequelae in long‐term survivors of childhood cancer (CVSS) study is a cohort of patients from Germany diagnosed with a neoplasia prior to 15 years of age in the time period 1980 to 1990. Late mortality was evaluated in a total of 4505 individuals who survived 5 years or more after the initial diagnosis (5‐year survivors). Survivors with a second primary tumor were excluded. Standardized mortality ratios (SMRs) were calculated. By December 2014, 400 patients had died. Available cause of death information from 188 individuals was used to estimate cause‐specific mortality for all deceased persons. Compared to the population of (former) West Germany, we observed an excess overall mortality risk (SMR = 9.53, 95% confidence interval [CI] = 8.62‐10.51). After correcting for missing cause of death information, an increased cancer mortality (SMR = 43.50, 95% CI = 25.79‐73.50) in the 5‐year survivors was detected. Cardiac death was ascertained in 14 individuals, resulting in an SMR of 10.85 (95% CI = 2.80‐32.02) after correcting for missing values. In conclusion, childhood cancer survivors diagnosed in Germany in 1980 to 1990 have a higher mortality risk overall and an elevated risk of dying from cancer and cardiac causes in particular. The results are consistent with those of international cohort studies. However, the reported results are based on few cases and individuals with secondary cancers were excluded.</jats:p>
Autoren
  • Hiltrud Merzenich
  • Dan Baaken
  • Astrid Schneider
  • Marie A Neu
  • Arthur Wingerter
  • Jörg Faber
  • Philipp S Wild
  • Claudia Spix
DOI
10.1002/ijc.33772
eISSN
1097-0215
ISSN
0020-7136
Ausgabe der Veröffentlichung
1
Zeitschrift
International Journal of Cancer
Sprache
en
Online publication date
2021
Paginierung
67 - 72
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/ijc.33772
Datum der Datenerfassung
2023
Titel
Mortality risk among <scp>5‐year</scp> survivors of childhood cancer in Germany—Results from the CVSS study (Cardiac and Vascular late Sequelae in long‐term Survivors of childhood cancer study)
Ausgabe der Zeitschrift
150

Datenquelle: Crossref

Andere Metadatenquellen:
Author's licence
CC-BY
Autoren
  • Hiltrud Merzenich
  • Dan Baaken
  • Astrid Schneider
  • Marie A Neu
  • Arthur Wingerter
  • Jörg Faber
  • Philipp S Wild
  • Claudia Spix
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.1002/ijc.33772
File(s) embargoed
false
Open access
true
ISSN
1097-0215
Ausgabe der Veröffentlichung
1
Zeitschrift
International journal of cancer
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
67 - 72
Datum der Veröffentlichung
2022
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/7710
Herausgeber
Wiley-Liss
Datum der Datenerfassung
2022
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Zugang
Public
Titel
Mortality risk among 5-year survivors of childhood cancer in Germany : results from the CVSS study (Cardiac and Vascular late Sequelae in long-term Survivors of childhood cancer study)
Ausgabe der Zeitschrift
150

Files

mortality_risk_among_5year_su-20220902164705834.pdf

Datenquelle: OPENSCIENCE.UB

Werkzeuge