Survival after secondary liver resection in metastatic colorectal cancer: Comparing data of three prospective randomized European trials (LICC, CELIM, FIRE‐3)

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Abstract
<jats:title>Abstract</jats:title><jats:p>Metastatic colorectal cancer (mCRC) patients with liver‐limited disease (LLD) have a chance of long‐term survival and potential cure after hepatic metastasectomy. However, the appropriate postoperative treatment strategy is still controversial. The CELIM and FIRE‐3 studies demonstrated that secondary hepatic resection significantly improved overall survival (OS). The objective of this analysis was to compare these favorable outcome data with recent results from the LICC trial investigating the antigen‐specific cancer vaccine tecemotide (L‐BLP25) as adjuvant therapy in mCRC patients with LLD after R0/R1 resection. Data from mCRC patients with LLD and secondary hepatic resection from each study were analyzed for efficacy outcomes based on patient characteristics, treatment and surveillance after surgery. In LICC, 40/121 (33%) patients, in CELIM 36/111 (32%) and in FIRE‐3‐LLD 29/133 (22%) patients were secondarily resected, respectively. Of those, 31 (77.5%) patients in LICC and all patients in CELIM were R0 resected. Median disease‐free survival after resection was 8.9 months in LICC, 9.9 months in CELIM. Median OS in secondarily resected patients was 66.1 months in LICC, 53.9 months in CELIM and 56.2 months in FIRE‐3‐LLD. Median age was about 5 years less in LICC compared to CELIM and FIRE‐3. Secondarily resected patients of LICC, CELIM and FIRE‐3 showed an impressive median survival with a tendency for improved survival for patients in the LICC trial. A younger patient cohort but also more selective surgery, improved resection techniques, deep responses and a close surveillance program after surgery in the LICC trial may have had a positive impact on survival.</jats:p>
Autoren
  • Markus Moehler
  • Gunnar Folprecht
  • Volker Heinemann
  • Julian Walter Holch
  • Annett Maderer
  • Stefan Kasper
  • Susanna Hegewisch‐Becker
  • Jan Schröder
  • Friedrich Overkamp
  • Frank Kullmann
  • Wolf Otto Bechstein
  • Matthias Vöhringer
  • Robert Öllinger
  • Florian Lordick
  • Michael Geißler
  • Armin Schulz‐Abelius
  • Bernhard Linz
  • Helga Bernhard
  • Andreas Paul
  • Irene Schmidtmann
  • Karin Potthoff
  • Carl Christoph Schimanski
DOI
10.1002/ijc.33881
eISSN
1097-0215
ISSN
0020-7136
Ausgabe der Veröffentlichung
8
Zeitschrift
International Journal of Cancer
Sprache
en
Online publication date
2021
Paginierung
1341 - 1349
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/ijc.33881
Datum der Datenerfassung
2023
Titel
Survival after secondary liver resection in metastatic colorectal cancer: Comparing data of three prospective randomized European trials (<scp>LICC</scp>, <scp>CELIM</scp>, <scp>FIRE</scp>‐3)
Ausgabe der Zeitschrift
150

Datenquelle: Crossref

Andere Metadatenquellen:
Author's licence
CC-BY-NC-ND
Autoren
  • Markus Moehler
  • Gunnar Folprecht
  • Volker Heinemann
  • Julian Walter Holch
  • Annett Maderer
  • Stefan Kasper
  • Susanna Hegewisch-Becker
  • Jan Schröder
  • Friedrich Overkamp
  • Frank Kullmann
  • Wolf Otto Bechstein
  • Matthias Vöhringer
  • Robert Öllinger
  • Florian Lordick
  • Michael Geißler
  • Armin Schulz-Abelius
  • Bernhard Linz
  • Helga Bernhard
  • Andreas Paul
  • Irene Schmidtmann
  • Karin Potthoff
  • Carl Christoph Schimanski
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.1002/ijc.33881
File(s) embargoed
false
Open access
true
ISSN
1097-0215
Ausgabe der Veröffentlichung
8
Zeitschrift
International journal of cancer
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
1341 - 1349
Datum der Veröffentlichung
2022
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/7692
Herausgeber
Wiley-Liss
Datum der Datenerfassung
2022
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Zugang
Public
Titel
Survival after secondary liver resection in metastatic colorectal cancer : comparing data of three prospective randomized European trials (LICC, CELIM, FIRE-3)
Ausgabe der Zeitschrift
150

Files

survival_after_secondary_live-20220902145126665.pdf

Datenquelle: OPENSCIENCE.UB

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