Five-year cumulative incidence and progression of age-related macular degeneration: results from the German population-based Gutenberg Health Study (GHS)

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>Age-related macular degeneration (AMD) is a major cause of visual impairment and blindness. This study evaluates the incidence and progression of AMD in a large German cohort.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>The Gutenberg Health Study (GHS) is a population-based, prospective, observational cohort study in Germany that includes 15,010 participants between 35 and 74 years of age. The baseline examination, including fundus photography, was conducted between 2007 and 2012, and the 5-year follow-up examination was performed between 2012 and 2017. AMD grading of fundus photographs was performed according to the Rotterdam Eye Study classification. The 5-year cumulative incidence and progression of AMD were calculated. Poisson regression analysis was conducted to investigate factors associated with the cumulative incidence and progression of AMD.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Six-thousand-eight-hundred-eighty-eight participants (49.8%, n = 3427 female) were included in the analysis. AMD prevalence was 8.5% [95% CI: 7.9–9.2%] at baseline and 10.3% [95% CI: 9.6–11.1%] at follow-up. The cumulative 5-year-incidence was 2.0% [1.7–2.4%]. AMD progression within 5 years was seen in 18.1% [95% CI: 15.1–21.5%] of the participants. AMD incidence and AMD progression were associated with higher age, for each 10-year increase in age, the risk of AMD doubles (RR = 2.30), and the risk of progression of the disease is increased by 1.6. while AMD incidence also with pseudophakic status.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>In summary, this population-based sample provides substantial epidemiologic data from a large German cohort, including data on progression and cumulative incidence of macular degeneration in younger age groups. AMD progression over 5 years is common in the German population, 18.1% of subjects with AMD showed progression in at least one eye in this time frame and is associated with higher age. Nevertheless, although usually defined to occur over the age of 50, in this cohort AMD occurred in 0.5% and AMD progression occurred in 5.4% of those already affected in the youngest age group before 50 years of age.</jats:p> </jats:sec>
Autoren
  • Christina A Korb
  • Hisham Elbaz
  • Alexander K Schuster
  • Stefan Nickels
  • Katharina A Ponto
  • Andreas Schulz
  • Philipp S Wild
  • Thomas Münzel
  • Manfred E Beutel
  • Irene Schmidtmann
  • Karl J Lackner
  • Tunde Peto
  • Norbert Pfeiffer
DOI
10.1007/s00417-021-05312-y
eISSN
1435-702X
ISSN
0721-832X
Ausgabe der Veröffentlichung
1
Zeitschrift
Graefe's Archive for Clinical and Experimental Ophthalmology
Sprache
en
Online publication date
2021
Paginierung
55 - 64
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/s00417-021-05312-y
Datum der Datenerfassung
2022
Titel
Five-year cumulative incidence and progression of age-related macular degeneration: results from the German population-based Gutenberg Health Study (GHS)
Ausgabe der Zeitschrift
260

Datenquelle: Crossref

Andere Metadatenquellen:
Author's licence
CC-BY
Autoren
  • Christina A Korb
  • Hisham Elbaz
  • Alexander K Schuster
  • Stefan Nickels
  • Katharina A Ponto
  • Andreas Schulz
  • Philipp S Wild
  • Thomas Münzel
  • Manfred E Beutel
  • Irene Schmidtmann
  • Karl J Lackner
  • Tunde Peto
  • Norbert Pfeiffer
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.1007/s00417-021-05312-y
File(s) embargoed
false
Open access
true
ISSN
1435-702X
Zeitschrift
Graefe's archive for clinical and experimental ophthalmology
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
55 - 64
Datum der Veröffentlichung
2022
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/7649
Herausgeber
Springer
Datum der Datenerfassung
2022
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Zugang
Public
Titel
Five-year cumulative incidence and progression of age-related macular degeneration : results from the German population-based Gutenberg Health Study (GHS)
Ausgabe der Zeitschrift
260

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fiveyear_cumulative_incidence-20220826160311488.pdf

Datenquelle: OPENSCIENCE.UB

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