Impact of Acute and Chronic Amyloid-β Peptide Exposure on Gut Microbial Commensals in the Mouse
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Malena dos Santos Guilherme
- Hristo Todorov
- Carina Osterhof
- Anton Moellerke
- Kristina Cub
- Thomas Hankeln
- Susanne Gerber
- Kristina Endres
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000539411200001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3389/fmicb.2020.01008
- Externe Identifier
- Clarivate Analytics Document Solution ID: LW8RN
- PubMed Identifier: 32508799
- ISSN
- 1664-302X
- Zeitschrift
- FRONTIERS IN MICROBIOLOGY
- Schlüsselwörter
- Alzheimer's disease
- microbiome
- anti-microbial
- Amyloid-beta peptide
- mouse model
- 5xFAD
- Artikelnummer
- ARTN 1008
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Titel
- Impact of Acute and Chronic Amyloid-β Peptide Exposure on Gut Microbial Commensals in the Mouse
- Sub types
- Article
- Ausgabe der Zeitschrift
- 11
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Malena dos Santos Guilherme
- Hristo Todorov
- Carina Osterhof
- Anton Möllerke
- Kristina Cub
- Thomas Hankeln
- Susanne Gerber
- Kristina Endres
- DOI
- 10.3389/fmicb.2020.01008
- eISSN
- 1664-302X
- Zeitschrift
- Frontiers in Microbiology
- Online publication date
- 2020
- Status
- Published online
- Herausgeber
- Frontiers Media SA
- Herausgeber URL
- http://dx.doi.org/10.3389/fmicb.2020.01008
- Datum der Datenerfassung
- 2020
- Titel
- Impact of Acute and Chronic Amyloid-β Peptide Exposure on Gut Microbial Commensals in the Mouse
- Ausgabe der Zeitschrift
- 11
Datenquelle: Crossref
- Abstract
- Alzheimer's disease (AD) is the most common form of dementia. Besides its cognitive phenotype, AD leads to crucial changes in gut microbiome composition in model mice and in patients, but the reported data are still highly inconsistent. Therefore, we investigated chronic effects of AD-characteristic neurotoxic amyloid-β (Aβ) peptides as provided by transgenic overexpression (5xFAD mouse model) and acute effects due to oral application of Aβ on gut microbes. Astonishingly, one-time feeding of wild type mice with Aβ<sub>42</sub> provoked immediate changes in gut microbiome composition (β diversity) as compared to controls. Such obvious changes were not observed when comparing 5xFAD mice with wild type littermates. However, acute as well as chronic exposure to Aβ significantly affected the abundance of numerous individual operational taxonomic units. This provides first evidence that acute <i>in vivo</i> exposure to Aβ results in a shift in the enteric microbiome. Furthermore, we suggest that chronic exposure to Aβ might trigger an adaptive response of gut microbiota which could thereby result in dysbiosis in model mice but also in human patients.
- Addresses
- Department of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
- Autoren
- Malena Dos Santos Guilherme
- Hristo Todorov
- Carina Osterhof
- Anton Möllerke
- Kristina Cub
- Thomas Hankeln
- Susanne Gerber
- Kristina Endres
- DOI
- 10.3389/fmicb.2020.01008
- eISSN
- 1664-302X
- Externe Identifier
- PubMed Identifier: 32508799
- PubMed Central ID: PMC7251927
- Funding acknowledgements
- Boehringer Ingelheim Fonds:
- Open access
- true
- ISSN
- 1664-302X
- Zeitschrift
- Frontiers in microbiology
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2020
- Open access status
- Open Access
- Paginierung
- 1008
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2020
- Titel
- Impact of Acute and Chronic Amyloid-β Peptide Exposure on Gut Microbial Commensals in the Mouse.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 11
Files
https://www.frontiersin.org/articles/10.3389/fmicb.2020.01008/pdf https://europepmc.org/articles/PMC7251927?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Alzheimer's disease (AD) is the most common form of dementia. Besides its cognitive phenotype, AD leads to crucial changes in gut microbiome composition in model mice and in patients, but the reported data are still highly inconsistent. Therefore, we investigated chronic effects of AD-characteristic neurotoxic amyloid-β (Aβ) peptides as provided by transgenic overexpression (5xFAD mouse model) and acute effects due to oral application of Aβ on gut microbes. Astonishingly, one-time feeding of wild type mice with Aβ42 provoked immediate changes in gut microbiome composition (β diversity) as compared to controls. Such obvious changes were not observed when comparing 5xFAD mice with wild type littermates. However, acute as well as chronic exposure to Aβ significantly affected the abundance of numerous individual operational taxonomic units. This provides first evidence that acute in vivo exposure to Aβ results in a shift in the enteric microbiome. Furthermore, we suggest that chronic exposure to Aβ might trigger an adaptive response of gut microbiota which could thereby result in dysbiosis in model mice but also in human patients.
- Date of acceptance
- 2020
- Autoren
- Malena Dos Santos Guilherme
- Hristo Todorov
- Carina Osterhof
- Anton Möllerke
- Kristina Cub
- Thomas Hankeln
- Susanne Gerber
- Kristina Endres
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/32508799
- DOI
- 10.3389/fmicb.2020.01008
- Externe Identifier
- PubMed Central ID: PMC7251927
- ISSN
- 1664-302X
- Zeitschrift
- Front Microbiol
- Schlüsselwörter
- 5xFAD
- Alzheimer’s disease
- Amyloid-β peptide
- anti-microbial
- microbiome
- mouse model
- Sprache
- eng
- Country
- Switzerland
- Paginierung
- 1008
- Datum der Veröffentlichung
- 2020
- Status
- Published online
- Titel
- Impact of Acute and Chronic Amyloid-β Peptide Exposure on Gut Microbial Commensals in the Mouse.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 11
Datenquelle: PubMed
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- Eigentum von