Poster | Pooled re-analysis to investigate the associations of laboratory markers with the cellfree DNA kinetics after bicycle and treadmill exercises

Publikationstyp:
Konferenzbeitrag
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Abstract
Background: Physical activity leads to strong workload and duration dependent increases of circulating cell-free DNA (cfDNA) in blood plasma. Therefore, cfDNA has been considered to be a relevant marker in exercise physiology. Studies indicate that incremental all out running exercise leads to higher cfDNA accumulation than respective cycling exercise. Here we investigated the increases of cfDNA after cycling or running exercise and its association with various laboratory values and physiological data. › Methods: In a pooled re-analysis the data of 96 incremental exercise tests (57 bicycle ergometer; 39 treadmill) of 79 healthy subjects (25.5 ± 4.3 years) were analyzed. Different blood parameters as well as venous cfDNA concentrations were measured pre- and post- exercise. During the tests, spiroergometry data as well as capillary lactate concentrations were determined. To investigate the differences between these two exercise modalities mean comparisons with mixed models and correlation analyses were applied. In addition, decision tree-based classification models were used for exploratory data analysis. › Results: After the incremental exercise tests the treadmill group showed 2.3 times higher venous cfDNA values compared to the cycling group [pre: 14.2 (12.7-16.0) vs. 14.2 (12.9-15.7) ng/ml; post: 164.6 (118.8- 241.4) vs. 71.3 (58.3-89.0) ng/ml; p < .001]. Postexercise, the lactate values and total energy expenditure did not show significant differences, and amongst all other blood parameters only slight differences were detected for leukocytes (p = .017) and lymphocytes (p < .001) between running and cycling. The decision tree-based models indicate that cfDNA is the most relevant laboratory marker to differentiate between the exercise types. Correlation analysis revealed a positive association between the differences of cfDNA with the differences of leukocytes (r = .330 ; p = .002) and lymphocytes (r = .287 ; p = .008). › Conclusion: The exploratory data analysis affirms that the two different exercise modalities lead to relevant differences in cfDNA accumulation, showing no differences in energy expenditure and lactate levels. Further research is required to better understand the factors leading to cfDNA release and to investigate if cfDNA increases could be associated with training load.
Autoren
  • Vincent Weber
  • Barlo Hillen
  • Alexandra Brahmer
  • Philipp Licht
  • Perikles Simon
  • Elmo Neuberger
Conference finish date
2021
ISSN
0344-5925
Conference place
Virtueller Kongress
Name of conference
Sports, Medicine and Health Summit
Online publication date
2021
Paginierung
95 - 95
Datum der Veröffentlichung
2021
Status
Published
Datum der Datenerfassung
2022
Conference start date
2021
Titel
Poster | Pooled re-analysis to investigate the associations of laboratory markers with the cellfree DNA kinetics after bicycle and treadmill exercises

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