Multicomponent Self‐Assembly of a Giant Heterometallic Polyoxotungstate Supercluster with Antitumor Activity

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Abstract
<jats:title>Abstract</jats:title><jats:p>The hierarchical aggregation of molecular nanostructures from multiple components is a grand synthetic challenge, which requires highly selective linkage control. We demonstrate how two orthogonal linkage groups, that is, organotin and lanthanide cations, can be used to drive the aggregation of a giant molecular metal oxide superstructure. The title compound {[(Sn(CH<jats:sub>3</jats:sub>)<jats:sub>2</jats:sub>)<jats:sub>2</jats:sub>O]<jats:sub>4</jats:sub>{[CeW<jats:sub>5</jats:sub>O<jats:sub>18</jats:sub>] [TeW<jats:sub>4</jats:sub>O<jats:sub>16</jats:sub>][CeSn(CH<jats:sub>3</jats:sub>)<jats:sub>2</jats:sub>]<jats:sub>4</jats:sub>[TeW<jats:sub>8</jats:sub>O<jats:sub>31</jats:sub>]<jats:sub>4</jats:sub>}<jats:sub>2</jats:sub>}<jats:sup>46−</jats:sup> (<jats:bold>1 a</jats:bold>) features dimensions of ca. 2.2×2.3×3.4 nm<jats:sup>3</jats:sup> and a molecular weight of ca. 25 kDa. Structural analysis shows the hierarchical aggregation from several independent subunits. Initial biomedical tests show that <jats:bold>1</jats:bold> features an inhibitory effect on the proliferation of HeLa cells based on an apoptosis pathway. In vivo experiments in mice reveal the antiproliferative activity of <jats:bold>1</jats:bold> and open new paths for further development of this new compound class.</jats:p>
Autoren
  • Jian‐Cai Liu
  • Jie‐Fei Wang
  • Qing Han
  • Ping Shangguan
  • Lu‐Lu Liu
  • Li‐Juan Chen
  • Jun‐Wei Zhao
  • Carsten Streb
  • Yu‐Fei Song
DOI
10.1002/ange.202017318
eISSN
1521-3757
ISSN
0044-8249
Ausgabe der Veröffentlichung
20
Zeitschrift
Angewandte Chemie
Sprache
en
Online publication date
2021
Paginierung
11253 - 11257
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/ange.202017318
Datum der Datenerfassung
2023
Titel
Multicomponent Self‐Assembly of a Giant Heterometallic Polyoxotungstate Supercluster with Antitumor Activity
Ausgabe der Zeitschrift
133

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