Reduction of depressive symptoms during inpatient treatment is not associated with changes in heart rate variability
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Sabrina Neyer
- Michael Witthoeft
- Mark Cropley
- Markus Pawelzik
- Ricardo Gregorio Lugo
- Stefan Sutterlin
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000632916600025&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1371/journal.pone.0248686
- Externe Identifier
- Clarivate Analytics Document Solution ID: RC6NY
- PubMed Identifier: 33755668
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- PLOS ONE
- Artikelnummer
- ARTN e0248686
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- Reduction of depressive symptoms during inpatient treatment is not associated with changes in heart rate variability
- Sub types
- Article
- Ausgabe der Zeitschrift
- 16
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>Vagally mediated heart rate variability (HRV) is a psychophysiological indicator of mental and physical health. Limited research suggests there is reduced vagal activity and resulting lower HRV in patients with Major Depressive Disorder (MDD); however little is actually known about the association between HRV and symptoms of depression and whether the association mirrors symptom improvement following psychotherapy. The aim of this study was to investigate the association between antidepressant therapy, symptom change and HRV in 50 inpatients (68% females; 17–68 years) with a diagnosis of MDD. Severity of depressive symptoms was assessed by self-report (Beck Depression Inventory II) and the Hamilton Rating Scale of Depression. Measures of vagally mediated HRV (root mean square of successive differences and high-frequency) were assessed at multiple measurement points before and after inpatient psychotherapeutic and psychiatric treatment. Results showed an expected negative correlation between HRV and depressive symptoms at intake. Depressive symptoms improved (d = 0.84) without corresponding change in HRV, demonstrating a de-coupling between this psychophysiological indicator and symptom severity. To our knowledge, this study is the first to examine an association between HRV and depressive symptoms before and after psychotherapy. The observed de-coupling of depression and HRV, and its methodological implications for future research are discussed.</jats:p>
- Autoren
- Sabrina Neyer
- Michael Witthöft
- Mark Cropley
- Markus Pawelzik
- Ricardo Gregorio Lugo
- Stefan Sütterlin
- DOI
- 10.1371/journal.pone.0248686
- Editoren
- Astrid M Kamperman
- eISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- PLOS ONE
- Sprache
- en
- Online publication date
- 2021
- Paginierung
- e0248686 - e0248686
- Status
- Published online
- Herausgeber
- Public Library of Science (PLoS)
- Herausgeber URL
- http://dx.doi.org/10.1371/journal.pone.0248686
- Datum der Datenerfassung
- 2021
- Titel
- Reduction of depressive symptoms during inpatient treatment is not associated with changes in heart rate variability
- Ausgabe der Zeitschrift
- 16
Datenquelle: Crossref
- Abstract
- Vagally mediated heart rate variability (HRV) is a psychophysiological indicator of mental and physical health. Limited research suggests there is reduced vagal activity and resulting lower HRV in patients with Major Depressive Disorder (MDD); however little is actually known about the association between HRV and symptoms of depression and whether the association mirrors symptom improvement following psychotherapy. The aim of this study was to investigate the association between antidepressant therapy, symptom change and HRV in 50 inpatients (68% females; 17-68 years) with a diagnosis of MDD. Severity of depressive symptoms was assessed by self-report (Beck Depression Inventory II) and the Hamilton Rating Scale of Depression. Measures of vagally mediated HRV (root mean square of successive differences and high-frequency) were assessed at multiple measurement points before and after inpatient psychotherapeutic and psychiatric treatment. Results showed an expected negative correlation between HRV and depressive symptoms at intake. Depressive symptoms improved (d = 0.84) without corresponding change in HRV, demonstrating a de-coupling between this psychophysiological indicator and symptom severity. To our knowledge, this study is the first to examine an association between HRV and depressive symptoms before and after psychotherapy. The observed de-coupling of depression and HRV, and its methodological implications for future research are discussed.
- Addresses
- Eos-Klinik, Münster, Germany.
- Autoren
- Sabrina Neyer
- Michael Witthöft
- Mark Cropley
- Markus Pawelzik
- Ricardo Gregorio Lugo
- Stefan Sütterlin
- DOI
- 10.1371/journal.pone.0248686
- eISSN
- 1932-6203
- Externe Identifier
- PubMed Identifier: 33755668
- PubMed Central ID: PMC7987172
- Open access
- true
- ISSN
- 1932-6203
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- PloS one
- Schlüsselwörter
- Humans
- Depressive Disorder, Major
- Heart Rate
- Adolescent
- Adult
- Aged
- Middle Aged
- Inpatients
- Female
- Male
- Young Adult
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2021
- Open access status
- Open Access
- Paginierung
- e0248686
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2021
- Titel
- Reduction of depressive symptoms during inpatient treatment is not associated with changes in heart rate variability.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 16
Files
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248686&type=printable https://europepmc.org/articles/PMC7987172?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Vagally mediated heart rate variability (HRV) is a psychophysiological indicator of mental and physical health. Limited research suggests there is reduced vagal activity and resulting lower HRV in patients with Major Depressive Disorder (MDD); however little is actually known about the association between HRV and symptoms of depression and whether the association mirrors symptom improvement following psychotherapy. The aim of this study was to investigate the association between antidepressant therapy, symptom change and HRV in 50 inpatients (68% females; 17-68 years) with a diagnosis of MDD. Severity of depressive symptoms was assessed by self-report (Beck Depression Inventory II) and the Hamilton Rating Scale of Depression. Measures of vagally mediated HRV (root mean square of successive differences and high-frequency) were assessed at multiple measurement points before and after inpatient psychotherapeutic and psychiatric treatment. Results showed an expected negative correlation between HRV and depressive symptoms at intake. Depressive symptoms improved (d = 0.84) without corresponding change in HRV, demonstrating a de-coupling between this psychophysiological indicator and symptom severity. To our knowledge, this study is the first to examine an association between HRV and depressive symptoms before and after psychotherapy. The observed de-coupling of depression and HRV, and its methodological implications for future research are discussed.
- Date of acceptance
- 2021
- Autoren
- Sabrina Neyer
- Michael Witthöft
- Mark Cropley
- Markus Pawelzik
- Ricardo Gregorio Lugo
- Stefan Sütterlin
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/33755668
- DOI
- 10.1371/journal.pone.0248686
- eISSN
- 1932-6203
- Externe Identifier
- PubMed Central ID: PMC7987172
- Ausgabe der Veröffentlichung
- 3
- Zeitschrift
- PLoS One
- Schlüsselwörter
- Adolescent
- Adult
- Aged
- Depressive Disorder, Major
- Female
- Heart Rate
- Humans
- Inpatients
- Male
- Middle Aged
- Young Adult
- Sprache
- eng
- Country
- United States
- Paginierung
- e0248686
- PII
- PONE-D-20-24073
- Datum der Veröffentlichung
- 2021
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Titel
- Reduction of depressive symptoms during inpatient treatment is not associated with changes in heart rate variability.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 16
Datenquelle: PubMed
- Beziehungen:
- Eigentum von