Nocebo hyperalgesia induced by implicit conditioning
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Anne-Kathrin Braescher
- Michael Witthoeft
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000469161400015&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.jbtep.2019.03.006
- eISSN
- 1873-7943
- Externe Identifier
- Clarivate Analytics Document Solution ID: HZ9FO
- PubMed Identifier: 30952053
- ISSN
- 0005-7916
- Zeitschrift
- JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY
- Schlüsselwörter
- Nocebo effect
- Implicit conditioning
- Electrodermal activity
- Contingency awareness
- Pain perception
- Paginierung
- 106 - 112
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Titel
- Nocebo hyperalgesia induced by implicit conditioning
- Sub types
- Article
- Ausgabe der Zeitschrift
- 64
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Anne-Kathrin Bräscher
- Michael Witthöft
- DOI
- 10.1016/j.jbtep.2019.03.006
- ISSN
- 0005-7916
- Zeitschrift
- Journal of Behavior Therapy and Experimental Psychiatry
- Sprache
- en
- Paginierung
- 106 - 112
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.jbtep.2019.03.006
- Datum der Datenerfassung
- 2021
- Titel
- Nocebo hyperalgesia induced by implicit conditioning
- Ausgabe der Zeitschrift
- 64
Datenquelle: Crossref
- Abstract
- <h4>Background and objectives</h4>Nocebo hyperalgesia (i.e., increased pain sensitivity based on expectations) can be induced by conditioning, but is supposed to be mediated by conscious expectation. Although recent evidence points to the feasibility of subliminal conditioning of nocebo hyperalgesia with masked faces, face processing might be a special case and the practical implications of subliminal conditioning remain questionable. This study aimed to implicitly condition nocebo hyperalgesia using supraliminal cues.<h4>Methods</h4>Implicit differential nocebo conditioning (N = 48 healthy participants) was implemented by coupling high and low painful electric stimuli to varying visual stimuli that only differed in the symmetry/asymmetry of one component (CS+/CS-) and contained further distracting components. In the test phase, only the low painful stimulus followed both CS to test for conditioned nocebo effects in intensity and aversiveness ratings and electrodermal activity. A behavioral contingency test and a post-experimental questionnaire assessed contingency awareness.<h4>Results</h4>A conditioned effect emerged in the aversiveness (p = .036; η<sup>2</sup> = 0.09), but not in the intensity rating (p = .195) while controlling for contingency awareness. Further, increased skin conductance levels in response to CS + emerged, irrespective of contingency awareness (p = .014, η<sup>2</sup> = 0.13). No conditioned responses in skin conductance responses emerged (p = .872).<h4>Limitations</h4>Expected effects only emerged in part of the outcome variables.<h4>Conclusions</h4>The results support the notion that implicit conditioning of nocebo hypoalgesia is feasible using a novel experimental conditioning design with supraliminal stimulus presentation, although further research is needed. So far, implicitly conditioned nocebo effects might have been underestimated despite vast clinical implications.
- Addresses
- Department for Clinical Psychology, Psychotherapy, and Experimental Psychopathology, Johannes Gutenberg University Mainz, Germany. Electronic address: abraesch@uni-mainz.de.
- Autoren
- Anne-Kathrin Bräscher
- Michael Witthöft
- DOI
- 10.1016/j.jbtep.2019.03.006
- eISSN
- 1873-7943
- Externe Identifier
- PubMed Identifier: 30952053
- Funding acknowledgements
- Johannes Gutenberg-Universität Mainz:
- Open access
- false
- ISSN
- 0005-7916
- Zeitschrift
- Journal of behavior therapy and experimental psychiatry
- Schlüsselwörter
- Humans
- Hyperalgesia
- Feasibility Studies
- Electric Stimulation
- Awareness
- Conditioning, Classical
- Pattern Recognition, Visual
- Subliminal Stimulation
- Galvanic Skin Response
- Adult
- Female
- Male
- Young Adult
- Pain Perception
- Nocebo Effect
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2019
- Paginierung
- 106 - 112
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Datum der Datenerfassung
- 2019
- Titel
- Nocebo hyperalgesia induced by implicit conditioning.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 64
Datenquelle: Europe PubMed Central
- Abstract
- BACKGROUND AND OBJECTIVES: Nocebo hyperalgesia (i.e., increased pain sensitivity based on expectations) can be induced by conditioning, but is supposed to be mediated by conscious expectation. Although recent evidence points to the feasibility of subliminal conditioning of nocebo hyperalgesia with masked faces, face processing might be a special case and the practical implications of subliminal conditioning remain questionable. This study aimed to implicitly condition nocebo hyperalgesia using supraliminal cues. METHODS: Implicit differential nocebo conditioning (N = 48 healthy participants) was implemented by coupling high and low painful electric stimuli to varying visual stimuli that only differed in the symmetry/asymmetry of one component (CS+/CS-) and contained further distracting components. In the test phase, only the low painful stimulus followed both CS to test for conditioned nocebo effects in intensity and aversiveness ratings and electrodermal activity. A behavioral contingency test and a post-experimental questionnaire assessed contingency awareness. RESULTS: A conditioned effect emerged in the aversiveness (p = .036; η2 = 0.09), but not in the intensity rating (p = .195) while controlling for contingency awareness. Further, increased skin conductance levels in response to CS + emerged, irrespective of contingency awareness (p = .014, η2 = 0.13). No conditioned responses in skin conductance responses emerged (p = .872). LIMITATIONS: Expected effects only emerged in part of the outcome variables. CONCLUSIONS: The results support the notion that implicit conditioning of nocebo hypoalgesia is feasible using a novel experimental conditioning design with supraliminal stimulus presentation, although further research is needed. So far, implicitly conditioned nocebo effects might have been underestimated despite vast clinical implications.
- Date of acceptance
- 2019
- Autoren
- Anne-Kathrin Bräscher
- Michael Witthöft
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/30952053
- DOI
- 10.1016/j.jbtep.2019.03.006
- eISSN
- 1873-7943
- Zeitschrift
- J Behav Ther Exp Psychiatry
- Schlüsselwörter
- Contingency awareness
- Electrodermal activity
- Implicit conditioning
- Nocebo effect
- Pain perception
- Adult
- Awareness
- Conditioning, Classical
- Electric Stimulation
- Feasibility Studies
- Female
- Galvanic Skin Response
- Humans
- Hyperalgesia
- Male
- Nocebo Effect
- Pain Perception
- Pattern Recognition, Visual
- Subliminal Stimulation
- Young Adult
- Sprache
- eng
- Country
- Netherlands
- Paginierung
- 106 - 112
- PII
- S0005-7916(18)30227-1
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Titel
- Nocebo hyperalgesia induced by implicit conditioning.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 64
Datenquelle: PubMed
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