Deficient Interhemispheric Connectivity Underlies Movement Irregularities in Parkinson's Disease

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Manuel Bange
  • Gabriel Gonzalez-Escamilla
  • Tabea Marquardt
  • Angela Radetz
  • Christian Dresel
  • Damian Herz
  • Wolfgang Immanuel Schollhorn
  • Sergiu Groppa
  • Muthuraman Muthuraman
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000747072700029&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3233/JPD-212840
eISSN
1877-718X
Externe Identifier
  • Clarivate Analytics Document Solution ID: YN2DC
  • PubMed Identifier: 34719510
ISSN
1877-7171
Ausgabe der Veröffentlichung
1
Zeitschrift
JOURNAL OF PARKINSONS DISEASE
Schlüsselwörter
  • Parkinson's disease
  • motor control
  • neural effective connectivity
  • fMRI
Paginierung
381 - 395
Datum der Veröffentlichung
2022
Status
Published
Titel
Deficient Interhemispheric Connectivity Underlies Movement Irregularities in Parkinson's Disease
Sub types
  • Article
Ausgabe der Zeitschrift
12

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:p>Background: Movement execution is impaired in patients with Parkinson’s disease. Evolving neurodegeneration leads to altered connectivity between distinct regions of the brain and altered activity at interconnected areas. How connectivity alterations influence complex movements like drawing spirals in Parkinson’s disease patients remains largely unexplored. Objective: We investigated whether deteriorations in interregional connectivity relate to impaired execution of drawing. Methods: Twenty-nine patients and 31 age-matched healthy control participants drew spirals with both hands on a digital graphics tablet, and the regularity of drawing execution was evaluated by sample entropy. We recorded resting-state fMRI and task-related EEG, and calculated the time-resolved partial directed coherence to estimate effective connectivity for both imaging modalities to determine the extent and directionality of interregional interactions. Results: Movement performance in Parkinson’s disease patients was characterized by increased sample entropy, corresponding to enhanced irregularities in task execution. Effective connectivity between the motor cortices of both hemispheres, derived from resting-state fMRI, was significantly reduced in Parkinson’s disease patients in comparison to controls. The connectivity strength in the nondominant to dominant hemisphere direction in both modalities was inversely correlated with irregularities during drawing, but not with the clinical state. Conclusion: Our findings suggest that interhemispheric connections are affected both at rest and during drawing movements by Parkinson’s disease. This provides novel evidence that disruptions of interhemispheric information exchange play a pivotal role for impairments of complex movement execution in Parkinson’s disease patients.</jats:p>
Autoren
  • Manuel Bange
  • Gabriel Gonzalez-Escamilla
  • Tabea Marquardt
  • Angela Radetz
  • Christian Dresel
  • Damian Herz
  • Wolfgang Immanuel Schöllhorn
  • Sergiu Groppa
  • Muthuraman Muthuraman
DOI
10.3233/jpd-212840
eISSN
1877-718X
ISSN
1877-7171
Ausgabe der Veröffentlichung
1
Zeitschrift
Journal of Parkinson's Disease
Paginierung
381 - 395
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
IOS Press
Herausgeber URL
http://dx.doi.org/10.3233/jpd-212840
Datum der Datenerfassung
2022
Titel
Deficient Interhemispheric Connectivity Underlies Movement Irregularities in Parkinson’s Disease
Ausgabe der Zeitschrift
12

Datenquelle: Crossref

Abstract
<h4>Background</h4>Movement execution is impaired in patients with Parkinson's disease. Evolving neurodegeneration leads to altered connectivity between distinct regions of the brain and altered activity at interconnected areas. How connectivity alterations influence complex movements like drawing spirals in Parkinson's disease patients remains largely unexplored.<h4>Objective</h4>We investigated whether deteriorations in interregional connectivity relate to impaired execution of drawing.<h4>Methods</h4>Twenty-nine patients and 31 age-matched healthy control participants drew spirals with both hands on a digital graphics tablet, and the regularity of drawing execution was evaluated by sample entropy. We recorded resting-state fMRI and task-related EEG, and calculated the time-resolved partial directed coherence to estimate effective connectivity for both imaging modalities to determine the extent and directionality of interregional interactions.<h4>Results</h4>Movement performance in Parkinson's disease patients was characterized by increased sample entropy, corresponding to enhanced irregularities in task execution. Effective connectivity between the motor cortices of both hemispheres, derived from resting-state fMRI, was significantly reduced in Parkinson's disease patients in comparison to controls. The connectivity strength in the nondominant to dominant hemisphere direction in both modalities was inversely correlated with irregularities during drawing, but not with the clinical state.<h4>Conclusion</h4>Our findings suggest that interhemispheric connections are affected both at rest and during drawing movements by Parkinson's disease. This provides novel evidence that disruptions of interhemispheric information exchange play a pivotal role for impairments of complex movement execution in Parkinson's disease patients.
Addresses
  • Section of Movement Disorders and Neurostimulation, Biomedical Statistics and Multimodal Signal Processing Unit, Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Autoren
  • Manuel Bange
  • Gabriel Gonzalez-Escamilla
  • Tabea Marquardt
  • Angela Radetz
  • Christian Dresel
  • Damian Herz
  • Wolfgang Immanuel Schöllhorn
  • Sergiu Groppa
  • Muthuraman Muthuraman
DOI
10.3233/jpd-212840
eISSN
1877-718X
Externe Identifier
  • PubMed Identifier: 34719510
Open access
false
ISSN
1877-7171
Ausgabe der Veröffentlichung
1
Zeitschrift
Journal of Parkinson's disease
Schlüsselwörter
  • Neural Pathways
  • Humans
  • Parkinson Disease
  • Magnetic Resonance Imaging
  • Brain Mapping
  • Movement
Sprache
eng
Medium
Print
Paginierung
381 - 395
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2021
Titel
Deficient Interhemispheric Connectivity Underlies Movement Irregularities in Parkinson's Disease.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
12

Datenquelle: Europe PubMed Central

Abstract
BACKGROUND: Movement execution is impaired in patients with Parkinson's disease. Evolving neurodegeneration leads to altered connectivity between distinct regions of the brain and altered activity at interconnected areas. How connectivity alterations influence complex movements like drawing spirals in Parkinson's disease patients remains largely unexplored. OBJECTIVE: We investigated whether deteriorations in interregional connectivity relate to impaired execution of drawing. METHODS: Twenty-nine patients and 31 age-matched healthy control participants drew spirals with both hands on a digital graphics tablet, and the regularity of drawing execution was evaluated by sample entropy. We recorded resting-state fMRI and task-related EEG, and calculated the time-resolved partial directed coherence to estimate effective connectivity for both imaging modalities to determine the extent and directionality of interregional interactions. RESULTS: Movement performance in Parkinson's disease patients was characterized by increased sample entropy, corresponding to enhanced irregularities in task execution. Effective connectivity between the motor cortices of both hemispheres, derived from resting-state fMRI, was significantly reduced in Parkinson's disease patients in comparison to controls. The connectivity strength in the nondominant to dominant hemisphere direction in both modalities was inversely correlated with irregularities during drawing, but not with the clinical state. CONCLUSION: Our findings suggest that interhemispheric connections are affected both at rest and during drawing movements by Parkinson's disease. This provides novel evidence that disruptions of interhemispheric information exchange play a pivotal role for impairments of complex movement execution in Parkinson's disease patients.
Autoren
  • Manuel Bange
  • Gabriel Gonzalez-Escamilla
  • Tabea Marquardt
  • Angela Radetz
  • Christian Dresel
  • Damian Herz
  • Wolfgang Immanuel Schöllhorn
  • Sergiu Groppa
  • Muthuraman Muthuraman
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34719510
DOI
10.3233/JPD-212840
eISSN
1877-718X
Ausgabe der Veröffentlichung
1
Zeitschrift
J Parkinsons Dis
Schlüsselwörter
  • Parkinson’s disease
  • fMRI
  • motor control
  • neural effective connectivity
  • Brain Mapping
  • Humans
  • Magnetic Resonance Imaging
  • Movement
  • Neural Pathways
  • Parkinson Disease
Sprache
eng
Country
Netherlands
Paginierung
381 - 395
PII
JPD212840
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Deficient Interhemispheric Connectivity Underlies Movement Irregularities in Parkinson's Disease.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
12

Datenquelle: PubMed

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