Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000795144100002&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2022.153985
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 1F4MZ
  • PubMed Identifier: 35358935
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Mode-of-action
  • Phytochemicals
  • Phytotherapy
  • Signal transduction
Artikelnummer
ARTN 153985
Datum der Veröffentlichung
2022
Status
Published
Titel
Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects
Sub types
  • Article
Ausgabe der Zeitschrift
100

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
DOI
10.1016/j.phymed.2022.153985
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
153985
Paginierung
153985 - 153985
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2022.153985
Datum der Datenerfassung
2023
Titel
Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects
Ausgabe der Zeitschrift
100

Datenquelle: Crossref

Abstract
<h4>Background</h4>Cancer is still an all-times issue due to a large and even increasing number of deaths. Impaired genes regulating cell proliferation and apoptosis are targets for the development of novel cancer treatments.<h4>Hypothesis</h4>Increased transcription of NADPH oxidase activator (NOXA), Bcl2-like11 (BIM), BH3-only proteins and p53 unregulated apoptosis modulator (PUMA) is caused by the imbalance between pro- and anti-apoptotic Bcl-2 proteins due to endoplasmic reticulum (ER) stress. The membranous network of ER is present in all eukaryotic cells. ER stress facilitates the interaction between Bax and PUMA, triggering the release of cytochrome C. As a main intracellular organelle, ER is responsible for translocation as well as post-translation modification and protein folding.<h4>Results</h4>Hesperetin is a cytoprotective flavonone, which acts against ER stress and protects from cell damage induced by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Hesperetin inhibits lipid peroxidation induced by Fe<sup>2+</sup> and l-ascorbic acid in rat brain homogenates.<h4>Conclusion</h4>This review deals with the anticancer effects of hesperetin regarding the regulation of ER stress as a principal mechanism in the pathogenesis of tumors.
Addresses
  • College of Pharmaceutical Sciences, Soochow University, 215123, China.
Autoren
DOI
10.1016/j.phymed.2022.153985
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 35358935
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Animals
  • Rats
  • Hesperidin
  • Antineoplastic Agents, Phytogenic
  • Apoptosis
  • Apoptosis Regulatory Proteins
  • Endoplasmic Reticulum Stress
Sprache
eng
Medium
Print-Electronic
Online publication date
2022
Paginierung
153985
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2022
Titel
Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
100

Datenquelle: Europe PubMed Central

Abstract
BACKGROUND: Cancer is still an all-times issue due to a large and even increasing number of deaths. Impaired genes regulating cell proliferation and apoptosis are targets for the development of novel cancer treatments. HYPOTHESIS: Increased transcription of NADPH oxidase activator (NOXA), Bcl2-like11 (BIM), BH3-only proteins and p53 unregulated apoptosis modulator (PUMA) is caused by the imbalance between pro- and anti-apoptotic Bcl-2 proteins due to endoplasmic reticulum (ER) stress. The membranous network of ER is present in all eukaryotic cells. ER stress facilitates the interaction between Bax and PUMA, triggering the release of cytochrome C. As a main intracellular organelle, ER is responsible for translocation as well as post-translation modification and protein folding. RESULTS: Hesperetin is a cytoprotective flavonone, which acts against ER stress and protects from cell damage induced by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Hesperetin inhibits lipid peroxidation induced by Fe2+ and l-ascorbic acid in rat brain homogenates. CONCLUSION: This review deals with the anticancer effects of hesperetin regarding the regulation of ER stress as a principal mechanism in the pathogenesis of tumors.
Date of acceptance
2022
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/35358935
DOI
10.1016/j.phymed.2022.153985
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Mode-of-action
  • Phytochemicals
  • Phytotherapy
  • Signal transduction
  • Animals
  • Antineoplastic Agents, Phytogenic
  • Apoptosis
  • Apoptosis Regulatory Proteins
  • Endoplasmic Reticulum Stress
  • Hesperidin
  • Rats
Sprache
eng
Country
Germany
Paginierung
153985
PII
S0944-7113(22)00063-0
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
100

Datenquelle: PubMed

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