Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Natalie Schuetzler
- Chantal Girwert
- Isabell Huegli
- Giriram Mohana
- Jean-Yves Roignant
- Stefanie Ryglewski
- Carsten Duch
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000459694400071&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1073/pnas.1813554116
- Externe Identifier
- Clarivate Analytics Document Solution ID: HM7YA
- PubMed Identifier: 30808766
- ISSN
- 0027-8424
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Schlüsselwörter
- biogenic amine
- calcium channel
- insect
- Dmca1D
- neuromodulation
- Paginierung
- 3805 - 3810
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Titel
- Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust <i>Drosophila</i> locomotion to nutritional state
- Sub types
- Article
- Ausgabe der Zeitschrift
- 116
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:title>Significance</jats:title> <jats:p> Biogenic amines, like norepinephrine, can act as neuromodulators to render animal behavior adaptive to changing external and internal conditions. The <jats:italic>Drosophila</jats:italic> genetic model system has been used extensively to identify aminergic neurons which modulate cognitive, emotional, and motor behaviors, but the cellular targets and physiological consequences of aminergic modulation remain poorly understood. We show that nutritional state affects amine biosynthesis to tune the relative levels of octopamine and tyramine in central <jats:italic>Drosophila</jats:italic> neurons. Starvation increases octopamine and locomotion, whereas satiation increases tyramine, which acts directly on motoneurons to decrease L-type calcium current and excitability. Both effects are required to adjust locomotor behavior to nutritional state. Therefore, adaptive behavior can be controlled on the level of motoneuron modulation and amine biosynthesis. </jats:p>
- Autoren
- Natalie Schützler
- Chantal Girwert
- Isabell Hügli
- Giriram Mohana
- Jean-Yves Roignant
- Stefanie Ryglewski
- Carsten Duch
- DOI
- 10.1073/pnas.1813554116
- eISSN
- 1091-6490
- ISSN
- 0027-8424
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Proceedings of the National Academy of Sciences
- Sprache
- en
- Online publication date
- 2019
- Paginierung
- 3805 - 3810
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Herausgeber
- Proceedings of the National Academy of Sciences
- Herausgeber URL
- http://dx.doi.org/10.1073/pnas.1813554116
- Datum der Datenerfassung
- 2022
- Titel
- Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust <i>Drosophila</i> locomotion to nutritional state
- Ausgabe der Zeitschrift
- 116
Datenquelle: Crossref
- Abstract
- Adrenergic signaling profoundly modulates animal behavior. For example, the invertebrate counterpart of norepinephrine, octopamine, and its biological precursor and functional antagonist, tyramine, adjust motor behavior to different nutritional states. In <i>Drosophila</i> larvae, food deprivation increases locomotor speed via octopamine-mediated structural plasticity of neuromuscular synapses, whereas tyramine reduces locomotor speed, but the underlying cellular and molecular mechanisms remain unknown. We show that tyramine is released into the CNS to reduce motoneuron intrinsic excitability and responses to excitatory cholinergic input, both by tyramine<sup>honoka</sup> receptor activation and by downstream decrease of L-type calcium current. This central effect of tyramine on motoneurons is required for the adaptive reduction of locomotor activity after feeding. Similarly, peripheral octopamine action on motoneurons has been reported to be required for increasing locomotion upon starvation. We further show that the level of tyramine-β-hydroxylase (TBH), the enzyme that converts tyramine into octopamine in aminergic neurons, is increased by food deprivation, thus selecting between antagonistic amine actions on motoneurons. Therefore, octopamine and tyramine provide global but distinctly different mechanisms to regulate motoneuron excitability and behavioral plasticity, and their antagonistic actions are balanced within a dynamic range by nutritional effects on TBH.
- Addresses
- Institute of Developmental Biology and Neurobiology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany.
- Autoren
- Natalie Schützler
- Chantal Girwert
- Isabell Hügli
- Giriram Mohana
- Jean-Yves Roignant
- Stefanie Ryglewski
- Carsten Duch
- DOI
- 10.1073/pnas.1813554116
- eISSN
- 1091-6490
- Externe Identifier
- PubMed Identifier: 30808766
- PubMed Central ID: PMC6397572
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft: Du 331/6-2
- Deutsche Forschungsgemeinschaft: RY 117/3-1
- Open access
- false
- ISSN
- 0027-8424
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Proceedings of the National Academy of Sciences of the United States of America
- Schlüsselwörter
- Motor Neurons
- Synapses
- Animals
- Drosophila melanogaster
- Octopamine
- Tyramine
- Mixed Function Oxygenases
- Calcium Channels, L-Type
- Receptors, Biogenic Amine
- Behavior, Animal
- Food Deprivation
- Nutritional Status
- Larva
- Locomotion
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2019
- Paginierung
- 3805 - 3810
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Datum der Datenerfassung
- 2019
- Titel
- Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust <i>Drosophila</i> locomotion to nutritional state.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 116
Files
https://www.pnas.org/content/pnas/116/9/3805.full.pdf https://europepmc.org/articles/PMC6397572?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Adrenergic signaling profoundly modulates animal behavior. For example, the invertebrate counterpart of norepinephrine, octopamine, and its biological precursor and functional antagonist, tyramine, adjust motor behavior to different nutritional states. In Drosophila larvae, food deprivation increases locomotor speed via octopamine-mediated structural plasticity of neuromuscular synapses, whereas tyramine reduces locomotor speed, but the underlying cellular and molecular mechanisms remain unknown. We show that tyramine is released into the CNS to reduce motoneuron intrinsic excitability and responses to excitatory cholinergic input, both by tyraminehonoka receptor activation and by downstream decrease of L-type calcium current. This central effect of tyramine on motoneurons is required for the adaptive reduction of locomotor activity after feeding. Similarly, peripheral octopamine action on motoneurons has been reported to be required for increasing locomotion upon starvation. We further show that the level of tyramine-β-hydroxylase (TBH), the enzyme that converts tyramine into octopamine in aminergic neurons, is increased by food deprivation, thus selecting between antagonistic amine actions on motoneurons. Therefore, octopamine and tyramine provide global but distinctly different mechanisms to regulate motoneuron excitability and behavioral plasticity, and their antagonistic actions are balanced within a dynamic range by nutritional effects on TBH.
- Autoren
- Natalie Schützler
- Chantal Girwert
- Isabell Hügli
- Giriram Mohana
- Jean-Yves Roignant
- Stefanie Ryglewski
- Carsten Duch
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/30808766
- DOI
- 10.1073/pnas.1813554116
- eISSN
- 1091-6490
- Externe Identifier
- PubMed Central ID: PMC6397572
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Proc Natl Acad Sci U S A
- Schlüsselwörter
- Dmca1D
- biogenic amine
- calcium channel
- insect
- neuromodulation
- Animals
- Behavior, Animal
- Calcium Channels, L-Type
- Drosophila melanogaster
- Food Deprivation
- Larva
- Locomotion
- Mixed Function Oxygenases
- Motor Neurons
- Nutritional Status
- Octopamine
- Receptors, Biogenic Amine
- Synapses
- Tyramine
- Sprache
- eng
- Country
- United States
- Paginierung
- 3805 - 3810
- PII
- 1813554116
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2019
- Titel
- Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 116
Datenquelle: PubMed
- Beziehungen:
- Eigentum von