Cell Adhesion on UV-Crosslinked Polyurethane Gels with Adjustable Mechanical Strength and Thermoresponsiveness
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Katharina Breul
- Elena Stengelin
- Moritz Urschbach
- Mihail Mondeshki
- Laura Wust
- Jason Sirleaf
- Sebastian Seitel
- Theresa Emt
- Sarah Pschierer
- Pol Besenius
- Sebastian Seiffert
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000709440400001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1002/marc.202100505
- eISSN
- 1521-3927
- Externe Identifier
- Clarivate Analytics Document Solution ID: XQ1JE
- PubMed Identifier: 34562294
- ISSN
- 1022-1336
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- MACROMOLECULAR RAPID COMMUNICATIONS
- Schlüsselwörter
- cell adhesion
- soft biomaterials
- thermoresponsive polyurethane hydrogels
- UV crosslinking
- Artikelnummer
- ARTN 2100505
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- Cell Adhesion on UV-Crosslinked Polyurethane Gels with Adjustable Mechanical Strength and Thermoresponsiveness
- Sub types
- Article
- Ausgabe der Zeitschrift
- 42
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Temperature‐responsive polyurethane (PU) hydrogels represent a versatile material platform for modern tissue engineering and biomedical applications. However, besides intrinsic advantages such as high mechanical strength and a hydrolysable backbone composition, plain PU materials are generally lacking bio‐adhesive properties. To overcome this shortcoming, the authors focus on the synthesis of thermoresponsive PU hydrogels with variable mechanical and cell adhesive properties obtained from linear precursor PUs based on poly(ethylene glycol)s (pEG) with different molar masses, isophorone diisocyanate, and a dimerizable dimethylmaleimide (DMMI)‐diol. The cloud point temperatures of the dilute, aqueous PU solutions depend linearly on the amphiphilic balance. Rheological gelation experiments under UV‐irradiation reveal the dependence of the gelation time on photosensitizer concentration and light intensity, while the finally obtained gel strength is determined by the polymer concentration and spacing of the crosslinks. The swelling ratios of these soft hydrogels show significant changes between 5 and 40 °C whereby the extent of this switch increases with the hydrophobicity of the precursor. Moreover, it is shown that the incorporation of a low amount of catechol groups into the networks through the DMMI dimerization reaction leads to strongly improved cell adhesive properties without significantly weakening the gels.</jats:p>
- Autoren
- Katharina Breul
- Elena Stengelin
- Moritz Urschbach
- Mihail Mondeshki
- Laura Wüst
- Jason Sirleaf
- Sebastian Seitel
- Theresa Emt
- Sarah Pschierer
- Pol Besenius
- Sebastian Seiffert
- DOI
- 10.1002/marc.202100505
- eISSN
- 1521-3927
- ISSN
- 1022-1336
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- Macromolecular Rapid Communications
- Sprache
- en
- Online publication date
- 2021
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Herausgeber
- Wiley
- Herausgeber URL
- http://dx.doi.org/10.1002/marc.202100505
- Datum der Datenerfassung
- 2023
- Titel
- Cell Adhesion on UV‐Crosslinked Polyurethane Gels with Adjustable Mechanical Strength and Thermoresponsiveness
- Ausgabe der Zeitschrift
- 42
Datenquelle: Crossref
- Abstract
- Temperature-responsive polyurethane (PU) hydrogels represent a versatile material platform for modern tissue engineering and biomedical applications. However, besides intrinsic advantages such as high mechanical strength and a hydrolysable backbone composition, plain PU materials are generally lacking bio-adhesive properties. To overcome this shortcoming, the authors focus on the synthesis of thermoresponsive PU hydrogels with variable mechanical and cell adhesive properties obtained from linear precursor PUs based on poly(ethylene glycol)s (pEG) with different molar masses, isophorone diisocyanate, and a dimerizable dimethylmaleimide (DMMI)-diol. The cloud point temperatures of the dilute, aqueous PU solutions depend linearly on the amphiphilic balance. Rheological gelation experiments under UV-irradiation reveal the dependence of the gelation time on photosensitizer concentration and light intensity, while the finally obtained gel strength is determined by the polymer concentration and spacing of the crosslinks. The swelling ratios of these soft hydrogels show significant changes between 5 and 40 °C whereby the extent of this switch increases with the hydrophobicity of the precursor. Moreover, it is shown that the incorporation of a low amount of catechol groups into the networks through the DMMI dimerization reaction leads to strongly improved cell adhesive properties without significantly weakening the gels.
- Addresses
- Department of Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, Mainz, 55128, Germany.
- Autoren
- Katharina Breul
- Elena Stengelin
- Moritz Urschbach
- Mihail Mondeshki
- Laura Wüst
- Jason Sirleaf
- Sebastian Seitel
- Theresa Emt
- Sarah Pschierer
- Pol Besenius
- Sebastian Seiffert
- DOI
- 10.1002/marc.202100505
- eISSN
- 1521-3927
- Externe Identifier
- PubMed Identifier: 34562294
- Open access
- false
- ISSN
- 1022-1336
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- Macromolecular rapid communications
- Schlüsselwörter
- Polyurethanes
- Hydrogels
- Adhesives
- Tissue Engineering
- Cell Adhesion
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2021
- Paginierung
- e2100505
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2021
- Titel
- Cell Adhesion on UV-Crosslinked Polyurethane Gels with Adjustable Mechanical Strength and Thermoresponsiveness.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 42
Datenquelle: Europe PubMed Central
- Abstract
- Temperature-responsive polyurethane (PU) hydrogels represent a versatile material platform for modern tissue engineering and biomedical applications. However, besides intrinsic advantages such as high mechanical strength and a hydrolysable backbone composition, plain PU materials are generally lacking bio-adhesive properties. To overcome this shortcoming, the authors focus on the synthesis of thermoresponsive PU hydrogels with variable mechanical and cell adhesive properties obtained from linear precursor PUs based on poly(ethylene glycol)s (pEG) with different molar masses, isophorone diisocyanate, and a dimerizable dimethylmaleimide (DMMI)-diol. The cloud point temperatures of the dilute, aqueous PU solutions depend linearly on the amphiphilic balance. Rheological gelation experiments under UV-irradiation reveal the dependence of the gelation time on photosensitizer concentration and light intensity, while the finally obtained gel strength is determined by the polymer concentration and spacing of the crosslinks. The swelling ratios of these soft hydrogels show significant changes between 5 and 40 °C whereby the extent of this switch increases with the hydrophobicity of the precursor. Moreover, it is shown that the incorporation of a low amount of catechol groups into the networks through the DMMI dimerization reaction leads to strongly improved cell adhesive properties without significantly weakening the gels.
- Autoren
- Katharina Breul
- Elena Stengelin
- Moritz Urschbach
- Mihail Mondeshki
- Laura Wüst
- Jason Sirleaf
- Sebastian Seitel
- Theresa Emt
- Sarah Pschierer
- Pol Besenius
- Sebastian Seiffert
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/34562294
- DOI
- 10.1002/marc.202100505
- eISSN
- 1521-3927
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- Macromol Rapid Commun
- Schlüsselwörter
- UV crosslinking
- cell adhesion
- soft biomaterials
- thermoresponsive polyurethane hydrogels
- Adhesives
- Cell Adhesion
- Hydrogels
- Polyurethanes
- Tissue Engineering
- Sprache
- eng
- Country
- Germany
- Paginierung
- e2100505
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Titel
- Cell Adhesion on UV-Crosslinked Polyurethane Gels with Adjustable Mechanical Strength and Thermoresponsiveness.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 42
Datenquelle: PubMed
- Author's licence
- CC-BY
- Autoren
- Katharina Breul
- Elena Stengelin
- Moritz Urschbach
- Mihail Mondeshki
- Laura Wüst
- Jason Sirleaf
- Sebastian Seitel
- Theresa Emt
- Sarah Pschierer
- Pol Besenius
- Sebastian Seiffert
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- JGU-Publikationen
- Resource version
- Published version
- DOI
- 10.1002/marc.202100505
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 1521-3927
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- Macromolecular rapid communications
- Schlüsselwörter
- 540 Chemie
- 540 Chemistry and allied sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 2100505
- Datum der Veröffentlichung
- 2021
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/8047
- Herausgeber
- Wiley-VCH
- Datum der Datenerfassung
- 2022
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Zugang
- Public
- Titel
- Cell adhesion on UV-crosslinked polyurethane gels with adjustable mechanical strength and thermoresponsiveness
- Ausgabe der Zeitschrift
- 42
Files
cell_adhesion_on_uvcrosslinke-20221014163928753.pdf
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