Defect-controlled softness, diffusive permeability, and mesh-topology of metallo-supramolecular hydrogels

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Paola Nicolella
  • Martha Franziska Koziol
  • Lucas Loeser
  • Kay Saalwaechter
  • Mostafa Ahmadi
  • Sebastian Seiffert
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000742391700001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1039/d1sm01456k
eISSN
1744-6848
Externe Identifier
  • Clarivate Analytics Document Solution ID: YR0GW
  • PubMed Identifier: 35029258
ISSN
1744-683X
Ausgabe der Veröffentlichung
5
Zeitschrift
SOFT MATTER
Paginierung
1071 - 1081
Datum der Veröffentlichung
2022
Status
Published
Titel
Defect-controlled softness, diffusive permeability, and mesh-topology of metallo-supramolecular hydrogels
Sub types
  • Article
Ausgabe der Zeitschrift
18

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:p>In a model 4-arm pEG supramolecular network, connectivity defects are systematically introduced with different ratios of 8-arm pEG, resulting in intra-molecular loops, and providing a softer polymer network and higher self-diffusion coefficients.</jats:p>
Autoren
  • Paola Nicolella
  • Martha Franziska Koziol
  • Lucas Löser
  • Kay Saalwächter
  • Mostafa Ahmadi
  • Sebastian Seiffert
DOI
10.1039/d1sm01456k
eISSN
1744-6848
ISSN
1744-683X
Ausgabe der Veröffentlichung
5
Zeitschrift
Soft Matter
Sprache
en
Online publication date
2022
Paginierung
1071 - 1081
Status
Published online
Herausgeber
Royal Society of Chemistry (RSC)
Herausgeber URL
http://dx.doi.org/10.1039/d1sm01456k
Datum der Datenerfassung
2024
Titel
Defect-controlled softness, diffusive permeability, and mesh-topology of metallo-supramolecular hydrogels
Ausgabe der Zeitschrift
18

Datenquelle: Crossref

Abstract
Hydrogels are polymer networks swollen in water; they are suitable materials for biomedical applications such as tissue engineering and drug delivery. In the latter, the controlled diffusion of small diffusants inside the network is essential, as it determines the release mechanism of the drug. In general, the diffusion inside a polymer network is controlled by its mesh-size. Here, we actively control the diffusivity and also the softness of metallo-supramolecular hydrogels <i>via</i> the network mesh-topology by introducing connectivity defects. A model polymer network is realized based on a 4-arm poly(ethylene glycol) (pEG) where each arm is capped with terpyridine moieties that are capable of forming metallo-supramolecular complexes with zinc ions. In this model network, we insert 8-arm pEG macromolecules that are functionalized with terpyridine at different ratios to create connectivity defects. With an increasing amount of 8-arm pEG, the polymer network forms more loops, as quantified by double quantum-NMR. This doped network shows an enhanced self-diffusivity of the building block molecules within the network, as examined by fluorescence recovery after photobleaching, and a higher softness, as investigated by oscillatory shear rheology. With these findings, we show that it is possible to tune the diffusivity and softness of hydrogels with defects in a rational fashion.
Addresses
  • Johannes Gutenberg-Universität Mainz, Department of Chemistry, Duesbergweg 10-14, D-55128 Mainz, Germany. sebastian.seiffert@uni-mainz.de.
Autoren
  • Paola Nicolella
  • Martha Franziska Koziol
  • Lucas Löser
  • Kay Saalwächter
  • Mostafa Ahmadi
  • Sebastian Seiffert
DOI
10.1039/d1sm01456k
eISSN
1744-6848
Externe Identifier
  • PubMed Identifier: 35029258
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft: 376900084
  • Deutsche Forschungsgemeinschaft: 397384169
  • European Commission: H2020-MSCA-ITN-2017 No. 765811
  • Deutsche Forschungsgemeinschaft: INST 247/878-1 FUGG
Open access
false
ISSN
1744-683X
Ausgabe der Veröffentlichung
5
Zeitschrift
Soft matter
Sprache
eng
Medium
Electronic
Online publication date
2022
Paginierung
1071 - 1081
Datum der Veröffentlichung
2022
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2022
Titel
Defect-controlled softness, diffusive permeability, and mesh-topology of metallo-supramolecular hydrogels.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
18

Datenquelle: Europe PubMed Central

Abstract
Hydrogels are polymer networks swollen in water; they are suitable materials for biomedical applications such as tissue engineering and drug delivery. In the latter, the controlled diffusion of small diffusants inside the network is essential, as it determines the release mechanism of the drug. In general, the diffusion inside a polymer network is controlled by its mesh-size. Here, we actively control the diffusivity and also the softness of metallo-supramolecular hydrogels via the network mesh-topology by introducing connectivity defects. A model polymer network is realized based on a 4-arm poly(ethylene glycol) (pEG) where each arm is capped with terpyridine moieties that are capable of forming metallo-supramolecular complexes with zinc ions. In this model network, we insert 8-arm pEG macromolecules that are functionalized with terpyridine at different ratios to create connectivity defects. With an increasing amount of 8-arm pEG, the polymer network forms more loops, as quantified by double quantum-NMR. This doped network shows an enhanced self-diffusivity of the building block molecules within the network, as examined by fluorescence recovery after photobleaching, and a higher softness, as investigated by oscillatory shear rheology. With these findings, we show that it is possible to tune the diffusivity and softness of hydrogels with defects in a rational fashion.
Autoren
  • Paola Nicolella
  • Martha Franziska Koziol
  • Lucas Löser
  • Kay Saalwächter
  • Mostafa Ahmadi
  • Sebastian Seiffert
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/35029258
DOI
10.1039/d1sm01456k
eISSN
1744-6848
Ausgabe der Veröffentlichung
5
Zeitschrift
Soft Matter
Sprache
eng
Country
England
Paginierung
1071 - 1081
Datum der Veröffentlichung
2022
Status
Published online
Titel
Defect-controlled softness, diffusive permeability, and mesh-topology of metallo-supramolecular hydrogels.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
18

Datenquelle: PubMed

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