Multiparametric Material Functionality of Microtissue-Based In Vitro Models as Alternatives to Animal Testing
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Elena Stengelin
- Julian Thiele
- Sebastian Seiffert
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000743873500001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1002/advs.202105319
- eISSN
- 2198-3844
- Externe Identifier
- Clarivate Analytics Document Solution ID: 0H5UF
- PubMed Identifier: 35043598
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- ADVANCED SCIENCE
- Schlüsselwörter
- 3R principle
- hydrogels
- in vitro models
- microtissue engineering
- Artikelnummer
- ARTN 2105319
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Titel
- Multiparametric Material Functionality of Microtissue-Based In Vitro Models as Alternatives to Animal Testing
- Sub types
- Review
- Ausgabe der Zeitschrift
- 9
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>With the definition of the 3R principle by Russel and Burch in 1959, the search for an adequate substitute for animal testing has become one of the most important tasks and challenges of this time, not only from an ethical, but also from a scientific, economic, and legal point of view. Microtissue‐based in vitro model systems offer a valuable approach to address this issue by accounting for the complexity of natural tissues in a simplified manner. To increase the functionality of these model systems and thus make their use as a substitute for animal testing more likely in the future, the fundamentals need to be continuously improved. Corresponding requirements exist in the development of multifunctional, hydrogel‐based materials, whose properties are considered in this review under the aspects of processability, adaptivity, biocompatibility, and stability/degradability.</jats:p>
- Autoren
- Elena Stengelin
- Julian Thiele
- Sebastian Seiffert
- DOI
- 10.1002/advs.202105319
- eISSN
- 2198-3844
- ISSN
- 2198-3844
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Advanced Science
- Sprache
- en
- Online publication date
- 2022
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Herausgeber
- Wiley
- Herausgeber URL
- http://dx.doi.org/10.1002/advs.202105319
- Datum der Datenerfassung
- 2023
- Titel
- Multiparametric Material Functionality of Microtissue‐Based In Vitro Models as Alternatives to Animal Testing
- Ausgabe der Zeitschrift
- 9
Datenquelle: Crossref
- Abstract
- With the definition of the 3R principle by Russel and Burch in 1959, the search for an adequate substitute for animal testing has become one of the most important tasks and challenges of this time, not only from an ethical, but also from a scientific, economic, and legal point of view. Microtissue-based in vitro model systems offer a valuable approach to address this issue by accounting for the complexity of natural tissues in a simplified manner. To increase the functionality of these model systems and thus make their use as a substitute for animal testing more likely in the future, the fundamentals need to be continuously improved. Corresponding requirements exist in the development of multifunctional, hydrogel-based materials, whose properties are considered in this review under the aspects of processability, adaptivity, biocompatibility, and stability/degradability.
- Addresses
- Department of Chemistry, Johannes Gutenberg-University Mainz, D-55128, Mainz, Germany.
- Autoren
- Elena Stengelin
- Julian Thiele
- Sebastian Seiffert
- DOI
- 10.1002/advs.202105319
- eISSN
- 2198-3844
- Externe Identifier
- PubMed Identifier: 35043598
- PubMed Central ID: PMC8981905
- Funding acknowledgements
- European Union's Horizon 2020 research and innovation program: 852065
- DFG Research Training Group 1865 "Hydrogel-based microsystems":
- Volkswagen Foundation "Change of Course":
- Open access
- true
- ISSN
- 2198-3844
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Advanced science (Weinheim, Baden-Wurttemberg, Germany)
- Schlüsselwörter
- Animals
- Hydrogels
- Animal Testing Alternatives
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2022
- Open access status
- Open Access
- Paginierung
- e2105319
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2022
- Titel
- Multiparametric Material Functionality of Microtissue-Based In Vitro Models as Alternatives to Animal Testing.
- Sub types
- Research Support, Non-U.S. Gov't
- review-article
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 9
Files
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202105319 https://europepmc.org/articles/PMC8981905?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- With the definition of the 3R principle by Russel and Burch in 1959, the search for an adequate substitute for animal testing has become one of the most important tasks and challenges of this time, not only from an ethical, but also from a scientific, economic, and legal point of view. Microtissue-based in vitro model systems offer a valuable approach to address this issue by accounting for the complexity of natural tissues in a simplified manner. To increase the functionality of these model systems and thus make their use as a substitute for animal testing more likely in the future, the fundamentals need to be continuously improved. Corresponding requirements exist in the development of multifunctional, hydrogel-based materials, whose properties are considered in this review under the aspects of processability, adaptivity, biocompatibility, and stability/degradability.
- Autoren
- Elena Stengelin
- Julian Thiele
- Sebastian Seiffert
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/35043598
- DOI
- 10.1002/advs.202105319
- eISSN
- 2198-3844
- Externe Identifier
- PubMed Central ID: PMC8981905
- Funding acknowledgements
- DFG Research Training Group 1865 "Hydrogel-based microsystems":
- Volkswagen Foundation "Change of Course":
- European Union's Horizon 2020 research and innovation program: 852065
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Adv Sci (Weinh)
- Schlüsselwörter
- 3R principle
- hydrogels
- in vitro models
- microtissue engineering
- Animal Testing Alternatives
- Animals
- Hydrogels
- Sprache
- eng
- Country
- Germany
- Paginierung
- e2105319
- Datum der Veröffentlichung
- 2022
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Multiparametric Material Functionality of Microtissue-Based In Vitro Models as Alternatives to Animal Testing.
- Sub types
- Journal Article
- Review
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 9
Datenquelle: PubMed
- Author's licence
- CC-BY
- Autoren
- Elena Stengelin
- Julian Thiele
- Sebastian Seiffert
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- JGU-Publikationen
- Resource version
- Published version
- DOI
- 10.1002/advs.202105319
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 2198-3844
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Advanced science
- Schlüsselwörter
- 540 Chemie
- 540 Chemistry and allied sciences
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 2105319
- Datum der Veröffentlichung
- 2022
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/8461
- Herausgeber
- Wiley-VCH
- Datum der Datenerfassung
- 2022
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Zugang
- Public
- Titel
- Multiparametric material functionality of microtissue-based in vitro models as alternatives to animal testing
- Ausgabe der Zeitschrift
- 9
Files
multiparametric_material_func-20221130115829820.pdf
Datenquelle: OPENSCIENCE.UB
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- Eigentum von