Extracellular Vesicles in neural cell interaction and CNS homeostasis

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Andrea Schnatz
  • Christina Mueller
  • Alexandra Brahmer
  • Eva-Maria Kraemer-Albers
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000683807800003&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1096/fba.2021-00035
eISSN
2573-9832
Externe Identifier
  • Clarivate Analytics Document Solution ID: TY5EO
  • PubMed Identifier: 34377954
Ausgabe der Veröffentlichung
8
Zeitschrift
FASEB BIOADVANCES
Schlüsselwörter
  • axonal maintenance
  • blood-brain barrier
  • exosomes
  • in vivo imaging
  • microvesicles
  • neuroinflammation
  • neuron-glia interaction
  • synaptic plasticity
Paginierung
577 - 592
Datum der Veröffentlichung
2021
Status
Published
Titel
Extracellular Vesicles in neural cell interaction and CNS homeostasis
Sub types
  • Review
Ausgabe der Zeitschrift
3

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • Andrea Schnatz
  • Christina Müller
  • Alexandra Brahmer
  • Eva‐Maria Krämer‐Albers
DOI
10.1096/fba.2021-00035
eISSN
2573-9832
ISSN
2573-9832
Ausgabe der Veröffentlichung
8
Zeitschrift
FASEB BioAdvances
Sprache
en
Online publication date
2021
Paginierung
577 - 592
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1096/fba.2021-00035
Datum der Datenerfassung
2021
Titel
Extracellular Vesicles in neural cell interaction and CNS homeostasis
Ausgabe der Zeitschrift
3

Datenquelle: Crossref

Abstract
Central nervous system (CNS) homeostasis critically depends on the interaction between neurons and glia cells. Extracellular vesicles (EVs) recently emerged as versatile messengers in CNS cell communication. EVs are released by neurons and glia in activity-dependent manner and address multiple target cells within and outside the nervous system. Here, we summarize the recent advances in understanding the physiological roles of EVs in the nervous system and their ability to deliver signals across the CNS barriers. In addition to the disposal of cellular components via EVs and clearance by phagocytic cells, EVs are involved in plasticity-associated processes, mediate trophic support and neuroprotection, promote axonal maintenance, and modulate neuroinflammation. While individual functional components of the EV cargo are becoming progressively identified, the role of neural EVs as compound multimodal signaling entities remains to be elucidated. Novel transgenic models and imaging technologies allow EV tracking in vivo and provide further insight into EV targeting and their mode of action. Overall, EVs represent key players in the maintenance of CNS homeostasis essential for the lifelong performance of neural networks and thus provide a wide spectrum of biomedical applications.
Addresses
  • Institute of Developmental Biology and Neurobiology Biology of Extracellular Vesicles University of Mainz Mainz Germany.
Autoren
  • Andrea Schnatz
  • Christina Müller
  • Alexandra Brahmer
  • Eva-Maria Krämer-Albers
DOI
10.1096/fba.2021-00035
eISSN
2573-9832
Externe Identifier
  • PubMed Identifier: 34377954
  • PubMed Central ID: PMC8332475
Open access
true
ISSN
2573-9832
Ausgabe der Veröffentlichung
8
Zeitschrift
FASEB bioAdvances
Sprache
eng
Medium
Electronic-eCollection
Online publication date
2021
Open access status
Open Access
Paginierung
577 - 592
Datum der Veröffentlichung
2021
Status
Published
Publisher licence
CC BY-NC
Datum der Datenerfassung
2021
Titel
Extracellular Vesicles in neural cell interaction and CNS homeostasis.
Sub types
  • review-article
  • Review
  • Journal Article
Ausgabe der Zeitschrift
3

Files

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fba.2021-00035 https://europepmc.org/articles/PMC8332475?pdf=render

Datenquelle: Europe PubMed Central

Abstract
Central nervous system (CNS) homeostasis critically depends on the interaction between neurons and glia cells. Extracellular vesicles (EVs) recently emerged as versatile messengers in CNS cell communication. EVs are released by neurons and glia in activity-dependent manner and address multiple target cells within and outside the nervous system. Here, we summarize the recent advances in understanding the physiological roles of EVs in the nervous system and their ability to deliver signals across the CNS barriers. In addition to the disposal of cellular components via EVs and clearance by phagocytic cells, EVs are involved in plasticity-associated processes, mediate trophic support and neuroprotection, promote axonal maintenance, and modulate neuroinflammation. While individual functional components of the EV cargo are becoming progressively identified, the role of neural EVs as compound multimodal signaling entities remains to be elucidated. Novel transgenic models and imaging technologies allow EV tracking in vivo and provide further insight into EV targeting and their mode of action. Overall, EVs represent key players in the maintenance of CNS homeostasis essential for the lifelong performance of neural networks and thus provide a wide spectrum of biomedical applications.
Date of acceptance
2021
Autoren
  • Andrea Schnatz
  • Christina Müller
  • Alexandra Brahmer
  • Eva-Maria Krämer-Albers
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34377954
DOI
10.1096/fba.2021-00035
eISSN
2573-9832
Externe Identifier
  • PubMed Central ID: PMC8332475
Ausgabe der Veröffentlichung
8
Zeitschrift
FASEB Bioadv
Schlüsselwörter
  • axonal maintenance
  • blood–brain barrier
  • exosomes
  • in vivo imaging
  • microvesicles
  • neuroinflammation
  • neuron–glia interaction
  • synaptic plasticity
Sprache
eng
Country
United States
Paginierung
577 - 592
PII
FBA21234
Datum der Veröffentlichung
2021
Status
Published online
Titel
Extracellular Vesicles in neural cell interaction and CNS homeostasis.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
3

Datenquelle: PubMed

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