Antimicrobial Activity of Eucalyptus globulus, Azadirachta indica, Glycyrrhiza glabra, Rheum palmatum Extracts and Rhein against Porphyromonas gingivalis

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Lena Katharina Mueller-Heupt
  • Nina Vierengel
  • Jonathan Gross
  • Till Opatz
  • James Deschner
  • Friederike D von Loewenich
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000764716500001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3390/antibiotics11020186
Externe Identifier
  • Clarivate Analytics Document Solution ID: ZN0DR
  • PubMed Identifier: 35203789
ISSN
2079-6382
Ausgabe der Veröffentlichung
2
Zeitschrift
ANTIBIOTICS-BASEL
Schlüsselwörter
  • Azadirachta indica
  • broth microdilution
  • Glycyrrhiza glabra
  • plant extracts
  • Porphyromonas gingivalis
  • rhein
  • Rheum palmatum
Artikelnummer
ARTN 186
Datum der Veröffentlichung
2022
Status
Published
Titel
Antimicrobial Activity of <i>Eucalyptus globulus</i>, <i>Azadirachta indica</i>, <i>Glycyrrhiza glabra</i>, <i>Rheum palmatum</i> Extracts and Rhein against <i>Porphyromonas gingivalis</i>
Sub types
  • Article
Ausgabe der Zeitschrift
11

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:p>Novel plant-derived antimicrobials are of interest in dentistry, especially in the treatment of periodontitis, since the use of established substances is associated with side effects and concerns of antimicrobial resistance have been raised. Thus, the present study was performed to quantify the antimicrobial efficacy of crude plant extracts against Porphyromonas gingivalis, a pathogen associated with periodontitis. The minimal inhibitory concentrations (MICs) of Eucalyptus globulus leaf, Azadirachta indica leaf, Glycyrrhiza glabra root and Rheum palmatum root extracts were determined by broth microdilution for P. gingivalis ATCC 33277 according to CLSI (Clinical and Laboratory Standards Institute). The MICs for the E. globulus, A. indica and G. glabra extracts ranged from 64 mg/L to 1024 mg/L. The lowest MIC was determined for an ethanolic R. palmatum extract with 4 mg/L. The MIC for the anthraquinone rhein was also measured, as the antimicrobial activity of P. palmatum root extracts can be partially traced back to rhein. Rhein showed a remarkably low MIC of 0.125 mg/L. However, the major compounds of the R. palmatum root extract were not further separated and purified. In conclusion, R. palmatum root extracts should be further studied for the treatment of periodontitis.</jats:p>
Autoren
  • Lena Katharina Müller-Heupt
  • Nina Vierengel
  • Jonathan Groß
  • Till Opatz
  • James Deschner
  • Friederike D von Loewenich
DOI
10.3390/antibiotics11020186
eISSN
2079-6382
Ausgabe der Veröffentlichung
2
Zeitschrift
Antibiotics
Sprache
en
Online publication date
2022
Paginierung
186 - 186
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/antibiotics11020186
Datum der Datenerfassung
2022
Titel
Antimicrobial Activity of Eucalyptus globulus, Azadirachta indica, Glycyrrhiza glabra, Rheum palmatum Extracts and Rhein against Porphyromonas gingivalis
Ausgabe der Zeitschrift
11

Datenquelle: Crossref

Abstract
Novel plant-derived antimicrobials are of interest in dentistry, especially in the treatment of periodontitis, since the use of established substances is associated with side effects and concerns of antimicrobial resistance have been raised. Thus, the present study was performed to quantify the antimicrobial efficacy of crude plant extracts against <i>Porphyromonas gingivalis</i>, a pathogen associated with periodontitis. The minimal inhibitory concentrations (MICs) of <i>Eucalyptus globulus</i> leaf, <i>Azadirachta indica</i> leaf, <i>Glycyrrhiza glabra</i> root and <i>Rheum palmatum</i> root extracts were determined by broth microdilution for <i>P. gingivalis</i> ATCC 33277 according to CLSI (Clinical and Laboratory Standards Institute). The MICs for the <i>E. globulus</i>, <i>A. indica</i> and <i>G. glabra</i> extracts ranged from 64 mg/L to 1024 mg/L. The lowest MIC was determined for an ethanolic <i>R. palmatum</i> extract with 4 mg/L. The MIC for the anthraquinone rhein was also measured, as the antimicrobial activity of <i>P. palmatum</i> root extracts can be partially traced back to rhein. Rhein showed a remarkably low MIC of 0.125 mg/L. However, the major compounds of the <i>R. palmatum</i> root extract were not further separated and purified. In conclusion, <i>R. palmatum</i> root extracts should be further studied for the treatment of periodontitis.
Addresses
  • Department of Oral and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, D-55131 Mainz, Germany.
Autoren
  • Lena Katharina Müller-Heupt
  • Nina Vierengel
  • Jonathan Groß
  • Till Opatz
  • James Deschner
  • Friederike D von Loewenich
DOI
10.3390/antibiotics11020186
eISSN
2079-6382
Externe Identifier
  • PubMed Identifier: 35203789
  • PubMed Central ID: PMC8868162
Funding acknowledgements
  • Ministry of economics, Rhineland-palatinate: Startup Innovativ
Open access
true
ISSN
2079-6382
Ausgabe der Veröffentlichung
2
Zeitschrift
Antibiotics (Basel, Switzerland)
Sprache
eng
Medium
Electronic
Online publication date
2022
Open access status
Open Access
Paginierung
186
Datum der Veröffentlichung
2022
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2022
Titel
Antimicrobial Activity of <i>Eucalyptus globulus</i>, <i>Azadirachta indica</i>, <i>Glycyrrhiza glabra</i>, <i>Rheum palmatum</i> Extracts and Rhein against <i>Porphyromonas gingivalis</i>.
Sub types
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
11

Files

https://www.mdpi.com/2079-6382/11/2/186/pdf?version=1644564867 https://europepmc.org/articles/PMC8868162?pdf=render

Datenquelle: Europe PubMed Central

Abstract
Novel plant-derived antimicrobials are of interest in dentistry, especially in the treatment of periodontitis, since the use of established substances is associated with side effects and concerns of antimicrobial resistance have been raised. Thus, the present study was performed to quantify the antimicrobial efficacy of crude plant extracts against Porphyromonas gingivalis, a pathogen associated with periodontitis. The minimal inhibitory concentrations (MICs) of Eucalyptus globulus leaf, Azadirachta indica leaf, Glycyrrhiza glabra root and Rheum palmatum root extracts were determined by broth microdilution for P. gingivalis ATCC 33277 according to CLSI (Clinical and Laboratory Standards Institute). The MICs for the E. globulus, A. indica and G. glabra extracts ranged from 64 mg/L to 1024 mg/L. The lowest MIC was determined for an ethanolic R. palmatum extract with 4 mg/L. The MIC for the anthraquinone rhein was also measured, as the antimicrobial activity of P. palmatum root extracts can be partially traced back to rhein. Rhein showed a remarkably low MIC of 0.125 mg/L. However, the major compounds of the R. palmatum root extract were not further separated and purified. In conclusion, R. palmatum root extracts should be further studied for the treatment of periodontitis.
Date of acceptance
2022
Autoren
  • Lena Katharina Müller-Heupt
  • Nina Vierengel
  • Jonathan Groß
  • Till Opatz
  • James Deschner
  • Friederike D von Loewenich
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/35203789
DOI
10.3390/antibiotics11020186
Externe Identifier
  • PubMed Central ID: PMC8868162
Funding acknowledgements
  • Ministry of economics, Rhineland-palatinate: Startup Innovativ
ISSN
2079-6382
Ausgabe der Veröffentlichung
2
Zeitschrift
Antibiotics (Basel)
Schlüsselwörter
  • Azadirachta indica
  • Glycyrrhiza glabra
  • Porphyromonas gingivalis
  • Rheum palmatum
  • broth microdilution
  • plant extracts
  • rhein
Sprache
eng
Country
Switzerland
PII
antibiotics11020186
Datum der Veröffentlichung
2022
Status
Published online
Titel
Antimicrobial Activity of Eucalyptus globulus, Azadirachta indica, Glycyrrhiza glabra, Rheum palmatum Extracts and Rhein against Porphyromonas gingivalis.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
11

Datenquelle: PubMed

Author's licence
CC-BY
Autoren
  • Lena Katharina Müller-Heupt
  • Nina Vierengel
  • Jonathan Groß
  • Till Opatz
  • James Deschner
  • Friederike D von Loewenich
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • DFG-491381577-G
Resource version
Published version
DOI
10.3390/antibiotics11020186
Funding acknowledgements
  • Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577
File(s) embargoed
false
Open access
true
ISSN
2079-6382
Ausgabe der Veröffentlichung
2
Zeitschrift
Antibiotics
Schlüsselwörter
  • 610 Medizin
  • 610 Medical sciences
Sprache
eng
Open access status
Open Access
Paginierung
186
Datum der Veröffentlichung
2022
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/8682
Herausgeber
MDPI
Datum der Datenerfassung
2023
Datum, an dem der Datensatz öffentlich gemacht wurde
2023
Zugang
Public
Titel
Antimicrobial activity of Eucalyptus globulus, Azadirachta indica, Glycyrrhiza glabra, Rheum palmatum extracts and rhein against Porphyromonas gingivalis
Ausgabe der Zeitschrift
11

Files

antimicrobial_activity_of_euc-20230126112652399.pdf

Datenquelle: OPENSCIENCE.UB

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