Cortical folding in patients with bipolar disorder or unipolar depression

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Jani Penttilae
  • Marie-Laure Paillere-Martinot
  • Jean-Luc Martinot
  • Damien Ringuenet
  • Michele Wessa
  • Josselin Houenou
  • Thierry Gallarda
  • Frank Bellivier
  • Andre Galinowski
  • Pascale Bruguiere
  • Francois Pinabel
  • Marion Leboyer
  • Jean-Pierre Olie
  • Edouard Duchesnay
  • Eric Artiges
  • Jean-Francois Mangin
  • Arnaud Cachia
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000263701300007&DestLinkType=FullRecord&DestApp=WOS_CPL
eISSN
1488-2434
Externe Identifier
  • Clarivate Analytics Document Solution ID: 412CR
  • PubMed Identifier: 19270763
ISSN
1180-4882
Ausgabe der Veröffentlichung
2
Zeitschrift
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
Paginierung
127 - 135
Datum der Veröffentlichung
2009
Status
Published
Titel
Cortical folding in patients with bipolar disorder or unipolar depression
Sub types
  • Article
Ausgabe der Zeitschrift
34

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<h4>Background</h4>Analysis of cortical folding may provide insight into neurodevelopment deviations, which, in turn, can predispose to depression that responds particularly poorly to medications. We hypothesized that patients with treatment-resistant depression would exhibit measurable alterations in cortical folding.<h4>Methods</h4>We computed hemispheric global sulcal indices (g-SIs) in T(1)-weighted magnetic resonance images obtained from 76 patients and 70 healthy controls. We separately searched for anatomic deviations in patients with bipolar disorder (16 patients with treatment-resistant depression, 25 with euthymia) and unipolar depression (35 patients with treatment-resistant depression).<h4>Results</h4>Compared with healthy controls, both groups of patients with treatment-resistant depression exhibited reduced g-SIs: in the right hemisphere among patients with bipolar disorder and in both hemispheres among those with unipolar depression. Patients with euthymic bipolar disorder did not differ significantly from depressed patients or healthy controls. Among patients with bipolar disorder who were taking lithium, we found positive correlations between current lithium dose and g-SIs in both hemispheres.<h4>Limitations</h4>We cannot estimate the extent to which the observed g-SI reductions are linked to treatment resistance and to what extent they are state-dependent. Furthermore, we cannot disentangle the impact of medications from that of the affective disorder. Finally, there is interindividual variation and overlap of g-SIs among patients and healthy controls that need to be considered when interpreting our results.<h4>Conclusion</h4>Reduced global cortical folding surface appears to be characteristic of patients with treatment-resistant depression, either unipolar or bipolar. In patients with bipolar disorder, treatment with lithium may modify cortical folding surface.
Addresses
  • INSERM, U797 Research Unit Neuroimaging & Psychiatry, CEA, Hospital Department Frédéric Joliot & Neurospin, Paris Sud University, Orsay, France.
Autoren
  • Jani Penttilä
  • Marie-Laure Paillère-Martinot
  • Jean-Luc Martinot
  • Damien Ringuenet
  • Michèle Wessa
  • Josselin Houenou
  • Thierry Gallarda
  • Frank Bellivier
  • André Galinowski
  • Pascale Bruguière
  • François Pinabel
  • Marion Leboyer
  • Jean-Pierre Olié
  • Edouard Duchesnay
  • Eric Artiges
  • Jean-François Mangin
  • Arnaud Cachia
eISSN
1488-2434
Externe Identifier
  • PubMed Identifier: 19270763
  • PubMed Central ID: PMC2647564
Open access
false
ISSN
1180-4882
Ausgabe der Veröffentlichung
2
Zeitschrift
Journal of psychiatry & neuroscience : JPN
Schlüsselwörter
  • Cerebral Cortex
  • Humans
  • Lithium Carbonate
  • Antimanic Agents
  • Antidepressive Agents
  • Magnetic Resonance Imaging
  • Bipolar Disorder
  • Depressive Disorder
  • Electroconvulsive Therapy
  • Psychiatric Status Rating Scales
  • Drug Resistance
  • Adult
  • Middle Aged
  • Female
  • Male
  • Functional Laterality
Sprache
eng
Medium
Print
Paginierung
127 - 135
Datum der Veröffentlichung
2009
Status
Published
Datum der Datenerfassung
2009
Titel
Cortical folding in patients with bipolar disorder or unipolar depression.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
34

Files

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19270763/pdf/?tool=EBI https://europepmc.org/articles/PMC2647564?pdf=render

Datenquelle: Europe PubMed Central

Abstract
BACKGROUND: Analysis of cortical folding may provide insight into neurodevelopment deviations, which, in turn, can predispose to depression that responds particularly poorly to medications. We hypothesized that patients with treatment-resistant depression would exhibit measurable alterations in cortical folding. METHODS: We computed hemispheric global sulcal indices (g-SIs) in T(1)-weighted magnetic resonance images obtained from 76 patients and 70 healthy controls. We separately searched for anatomic deviations in patients with bipolar disorder (16 patients with treatment-resistant depression, 25 with euthymia) and unipolar depression (35 patients with treatment-resistant depression). RESULTS: Compared with healthy controls, both groups of patients with treatment-resistant depression exhibited reduced g-SIs: in the right hemisphere among patients with bipolar disorder and in both hemispheres among those with unipolar depression. Patients with euthymic bipolar disorder did not differ significantly from depressed patients or healthy controls. Among patients with bipolar disorder who were taking lithium, we found positive correlations between current lithium dose and g-SIs in both hemispheres. LIMITATIONS: We cannot estimate the extent to which the observed g-SI reductions are linked to treatment resistance and to what extent they are state-dependent. Furthermore, we cannot disentangle the impact of medications from that of the affective disorder. Finally, there is interindividual variation and overlap of g-SIs among patients and healthy controls that need to be considered when interpreting our results. CONCLUSION: Reduced global cortical folding surface appears to be characteristic of patients with treatment-resistant depression, either unipolar or bipolar. In patients with bipolar disorder, treatment with lithium may modify cortical folding surface.
Autoren
  • Jani Penttilä
  • Marie-Laure Paillère-Martinot
  • Jean-Luc Martinot
  • Damien Ringuenet
  • Michèle Wessa
  • Josselin Houenou
  • Thierry Gallarda
  • Frank Bellivier
  • André Galinowski
  • Pascale Bruguière
  • François Pinabel
  • Marion Leboyer
  • Jean-Pierre Olié
  • Edouard Duchesnay
  • Eric Artiges
  • Jean-François Mangin
  • Arnaud Cachia
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/19270763
eISSN
1488-2434
Externe Identifier
  • PubMed Central ID: PMC2647564
Ausgabe der Veröffentlichung
2
Zeitschrift
J Psychiatry Neurosci
Schlüsselwörter
  • Adult
  • Antidepressive Agents
  • Antimanic Agents
  • Bipolar Disorder
  • Cerebral Cortex
  • Depressive Disorder
  • Drug Resistance
  • Electroconvulsive Therapy
  • Female
  • Functional Laterality
  • Humans
  • Lithium Carbonate
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales
Sprache
eng
Country
Canada
Paginierung
127 - 135
Datum der Veröffentlichung
2009
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2009
Titel
Cortical folding in patients with bipolar disorder or unipolar depression.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
34

Datenquelle: PubMed

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