Altered cortisol awakening response in posttraumatic stress disorder

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • M Wessa
  • N Rohleder
  • C Kirschbaum
  • H Flor
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000234881500005&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.psyneuen.2005.06.010
Externe Identifier
  • Clarivate Analytics Document Solution ID: 006FL
  • PubMed Identifier: 16154709
ISSN
0306-4530
Ausgabe der Veröffentlichung
2
Zeitschrift
PSYCHONEUROENDOCRINOLOGY
Schlüsselwörter
  • posttraumatic stress disorder
  • salivary cortisol
  • awakening response
Paginierung
209 - 215
Datum der Veröffentlichung
2006
Status
Published
Titel
Altered cortisol awakening response in posttraumatic stress disorder
Sub types
  • Article
Ausgabe der Zeitschrift
31

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • M WESSA
  • N ROHLEDER
  • C KIRSCHBAUM
  • H FLOR
DOI
10.1016/j.psyneuen.2005.06.010
ISSN
0306-4530
Ausgabe der Veröffentlichung
2
Zeitschrift
Psychoneuroendocrinology
Sprache
en
Paginierung
209 - 215
Datum der Veröffentlichung
2006
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.psyneuen.2005.06.010
Datum der Datenerfassung
2019
Titel
Altered cortisol awakening response in posttraumatic stress disorder
Ausgabe der Zeitschrift
31

Datenquelle: Crossref

Abstract
An altered function of the hypothalamic-pituitary-adrenal axis is assumed to be characteristic for Posttraumatic Stress Disorder (PTSD), although there is inconsistent empirical evidence. Only few studies examined the awakening cortisol response and a daytime profile in PTSD. Salivary cortisol levels were measured at seven intervals from awakening until 8 PM in trauma-exposed subjects with (N=29) and without PTSD (N=19) and in 15 non-exposed controls. While the three groups did not differ with respect to their first cortisol level immediately after awakening, the expected cortisol increase to awakening 15-60 min later was significantly lower in PTSD patients compared to non-PTSD subjects and healthy controls. This effect remained stable when trauma-exposed subjects with comorbid major depression were excluded from the analysis. A significant negative correlation between the overall cortisol secretion (AUC(G)) and overall PTSD symptomatology and hyper-arousal symptoms was found. The findings are discussed in light of the hypothesis of a counterregulation of hyper-arousal symptoms and chronic stress in PTSD.
Addresses
  • Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, J 5, 68159 Mannheim, Germany. wessa@zi-mannheim.de
Autoren
DOI
10.1016/j.psyneuen.2005.06.010
eISSN
1873-3360
Externe Identifier
  • PubMed Identifier: 16154709
Open access
false
ISSN
0306-4530
Ausgabe der Veröffentlichung
2
Zeitschrift
Psychoneuroendocrinology
Schlüsselwörter
  • Pituitary-Adrenal System
  • Hypothalamo-Hypophyseal System
  • Saliva
  • Humans
  • Hydrocortisone
  • Analysis of Variance
  • Area Under Curve
  • Statistics, Nonparametric
  • Depression
  • Wakefulness
  • Stress Disorders, Post-Traumatic
  • Circadian Rhythm
  • Reference Values
  • Adult
  • Aged
  • Middle Aged
  • Female
  • Male
Sprache
eng
Medium
Print-Electronic
Online publication date
2005
Paginierung
209 - 215
Datum der Veröffentlichung
2006
Status
Published
Datum der Datenerfassung
2005
Titel
Altered cortisol awakening response in posttraumatic stress disorder.
Sub types
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
31

Datenquelle: Europe PubMed Central

Abstract
An altered function of the hypothalamic-pituitary-adrenal axis is assumed to be characteristic for Posttraumatic Stress Disorder (PTSD), although there is inconsistent empirical evidence. Only few studies examined the awakening cortisol response and a daytime profile in PTSD. Salivary cortisol levels were measured at seven intervals from awakening until 8 PM in trauma-exposed subjects with (N=29) and without PTSD (N=19) and in 15 non-exposed controls. While the three groups did not differ with respect to their first cortisol level immediately after awakening, the expected cortisol increase to awakening 15-60 min later was significantly lower in PTSD patients compared to non-PTSD subjects and healthy controls. This effect remained stable when trauma-exposed subjects with comorbid major depression were excluded from the analysis. A significant negative correlation between the overall cortisol secretion (AUC(G)) and overall PTSD symptomatology and hyper-arousal symptoms was found. The findings are discussed in light of the hypothesis of a counterregulation of hyper-arousal symptoms and chronic stress in PTSD.
Date of acceptance
2005
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/16154709
DOI
10.1016/j.psyneuen.2005.06.010
ISSN
0306-4530
Ausgabe der Veröffentlichung
2
Zeitschrift
Psychoneuroendocrinology
Schlüsselwörter
  • Adult
  • Aged
  • Analysis of Variance
  • Area Under Curve
  • Circadian Rhythm
  • Depression
  • Female
  • Humans
  • Hydrocortisone
  • Hypothalamo-Hypophyseal System
  • Male
  • Middle Aged
  • Pituitary-Adrenal System
  • Reference Values
  • Saliva
  • Statistics, Nonparametric
  • Stress Disorders, Post-Traumatic
  • Wakefulness
Sprache
eng
Country
England
Paginierung
209 - 215
PII
S0306-4530(05)00170-8
Datum der Veröffentlichung
2006
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2006
Titel
Altered cortisol awakening response in posttraumatic stress disorder.
Sub types
  • Controlled Clinical Trial
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
31

Datenquelle: PubMed

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