Microstructural white matter changes in euthymic bipolar patients: a whole-brain diffusion tensor imaging study

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Michele Wessa
  • Josselin Houenou
  • Marion Leboyer
  • Sandra Chanraud
  • Cyril Poupon
  • Jean-Luc Martinot
  • Marie-Laure Paillere-Martinot
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000267874900005&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1111/j.1399-5618.2009.00718.x
eISSN
1399-5618
Externe Identifier
  • Clarivate Analytics Document Solution ID: 469DD
  • PubMed Identifier: 19624389
ISSN
1398-5647
Ausgabe der Veröffentlichung
5
Zeitschrift
BIPOLAR DISORDERS
Schlüsselwörter
  • bipolar disorder
  • fractional anisotropy
  • mean diffusivity
  • remission
  • voxel-based analyses
Paginierung
504 - 514
Datum der Veröffentlichung
2009
Status
Published
Titel
Microstructural white matter changes in euthymic bipolar patients: a whole-brain diffusion tensor imaging study
Sub types
  • Article
Ausgabe der Zeitschrift
11

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:p><jats:bold>Objectives: </jats:bold> Brain structures of a distributed ventral‐limbic and dorsal brain network have been associated with altered mood states and emotion regulation in affective disorders. So far, diffusion tensor imaging studies in bipolar patients have focused on frontal/prefrontal brain regions and found alterations in white matter integrity in manic, depressed, and euthymic bipolar patients, observed as changes in fractional anisotropy and mean diffusivity. To extend previous findings, we investigated whole‐brain modifications in white matter integrity in euthymic bipolar patients with minimal manic and depressive symptoms.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Twenty‐two patients with a DSM‐IV‐TR diagnosis of bipolar I and II disorder in remission, with no lifetime or present comorbidities of substance abuse, and 21 sex‐ and age‐matched healthy controls underwent diffusion tensor imaging with diffusion gradients applied along 41 directions. Fractional anisotropy and mean diffusivity group differences were explored using two voxel‐based, whole‐brain analyses that differ in their normalization approaches.</jats:p><jats:p><jats:bold>Results: </jats:bold> Fractional anisotropy was significantly increased in bipolar patients relative to healthy controls in medial frontal, precentral, inferior parietal, and occipital white matter. No group differences in mean diffusivity were found.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> The result of increased fractional anisotropy in euthymic bipolar patients in the present study suggests increased directional coherence of white matter fibers in bipolar patients during remission.</jats:p>
Autoren
  • Michèle Wessa
  • Josselin Houenou
  • Marion Leboyer
  • Sandra Chanraud
  • Cyril Poupon
  • Jean‐Luc Martinot
  • Marie‐Laure Paillère‐Martinot
DOI
10.1111/j.1399-5618.2009.00718.x
eISSN
1399-5618
ISSN
1398-5647
Ausgabe der Veröffentlichung
5
Zeitschrift
Bipolar Disorders
Sprache
en
Online publication date
2009
Paginierung
504 - 514
Datum der Veröffentlichung
2009
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1111/j.1399-5618.2009.00718.x
Datum der Datenerfassung
2023
Titel
Microstructural white matter changes in euthymic bipolar patients: a whole‐brain diffusion tensor imaging study
Ausgabe der Zeitschrift
11

Datenquelle: Crossref

Abstract
<h4>Objectives</h4>Brain structures of a distributed ventral-limbic and dorsal brain network have been associated with altered mood states and emotion regulation in affective disorders. So far, diffusion tensor imaging studies in bipolar patients have focused on frontal/prefrontal brain regions and found alterations in white matter integrity in manic, depressed, and euthymic bipolar patients, observed as changes in fractional anisotropy and mean diffusivity. To extend previous findings, we investigated whole-brain modifications in white matter integrity in euthymic bipolar patients with minimal manic and depressive symptoms.<h4>Methods</h4>Twenty-two patients with a DSM-IV-TR diagnosis of bipolar I and II disorder in remission, with no lifetime or present comorbidities of substance abuse, and 21 sex- and age-matched healthy controls underwent diffusion tensor imaging with diffusion gradients applied along 41 directions. Fractional anisotropy and mean diffusivity group differences were explored using two voxel-based, whole-brain analyses that differ in their normalization approaches.<h4>Results</h4>Fractional anisotropy was significantly increased in bipolar patients relative to healthy controls in medial frontal, precentral, inferior parietal, and occipital white matter. No group differences in mean diffusivity were found.<h4>Conclusions</h4>The result of increased fractional anisotropy in euthymic bipolar patients in the present study suggests increased directional coherence of white matter fibers in bipolar patients during remission.
Addresses
  • INSERM, U797, CEA-INSERM U797 Neuroimaging and Psychiatry, IFR49, University Paris Sud, University Paris 5, Hospital Department Frédéric Joliot, IBM, Orsay, France. michele.wessa@zi-mannheim.de
Autoren
  • Michèle Wessa
  • Josselin Houenou
  • Marion Leboyer
  • Sandra Chanraud
  • Cyril Poupon
  • Jean-Luc Martinot
  • Marie-Laure Paillère-Martinot
DOI
10.1111/j.1399-5618.2009.00718.x
eISSN
1399-5618
Externe Identifier
  • PubMed Identifier: 19624389
Open access
false
ISSN
1398-5647
Ausgabe der Veröffentlichung
5
Zeitschrift
Bipolar disorders
Schlüsselwörter
  • Brain
  • Neural Pathways
  • Humans
  • Diffusion Magnetic Resonance Imaging
  • Brain Mapping
  • Regression Analysis
  • Case-Control Studies
  • Bipolar Disorder
  • Anisotropy
  • Diagnostic and Statistical Manual of Mental Disorders
  • Adult
  • Middle Aged
  • Female
  • Male
Sprache
eng
Medium
Print
Paginierung
504 - 514
Datum der Veröffentlichung
2009
Status
Published
Datum der Datenerfassung
2009
Titel
Microstructural white matter changes in euthymic bipolar patients: a whole-brain diffusion tensor imaging study.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
11

Datenquelle: Europe PubMed Central

Abstract
OBJECTIVES: Brain structures of a distributed ventral-limbic and dorsal brain network have been associated with altered mood states and emotion regulation in affective disorders. So far, diffusion tensor imaging studies in bipolar patients have focused on frontal/prefrontal brain regions and found alterations in white matter integrity in manic, depressed, and euthymic bipolar patients, observed as changes in fractional anisotropy and mean diffusivity. To extend previous findings, we investigated whole-brain modifications in white matter integrity in euthymic bipolar patients with minimal manic and depressive symptoms. METHODS: Twenty-two patients with a DSM-IV-TR diagnosis of bipolar I and II disorder in remission, with no lifetime or present comorbidities of substance abuse, and 21 sex- and age-matched healthy controls underwent diffusion tensor imaging with diffusion gradients applied along 41 directions. Fractional anisotropy and mean diffusivity group differences were explored using two voxel-based, whole-brain analyses that differ in their normalization approaches. RESULTS: Fractional anisotropy was significantly increased in bipolar patients relative to healthy controls in medial frontal, precentral, inferior parietal, and occipital white matter. No group differences in mean diffusivity were found. CONCLUSIONS: The result of increased fractional anisotropy in euthymic bipolar patients in the present study suggests increased directional coherence of white matter fibers in bipolar patients during remission.
Autoren
  • Michèle Wessa
  • Josselin Houenou
  • Marion Leboyer
  • Sandra Chanraud
  • Cyril Poupon
  • Jean-Luc Martinot
  • Marie-Laure Paillère-Martinot
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/19624389
DOI
10.1111/j.1399-5618.2009.00718.x
eISSN
1399-5618
Ausgabe der Veröffentlichung
5
Zeitschrift
Bipolar Disord
Schlüsselwörter
  • Adult
  • Anisotropy
  • Bipolar Disorder
  • Brain
  • Brain Mapping
  • Case-Control Studies
  • Diagnostic and Statistical Manual of Mental Disorders
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neural Pathways
  • Regression Analysis
Sprache
eng
Country
Denmark
Paginierung
504 - 514
PII
BDI718
Datum der Veröffentlichung
2009
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2009
Titel
Microstructural white matter changes in euthymic bipolar patients: a whole-brain diffusion tensor imaging study.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
11

Datenquelle: PubMed

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