Diffusion Tensor Tractography in Mesencephalic Bundles: Relation to Mental Flexibility in Detoxified Alcohol-Dependent Subjects

Autoren

Sandra Chanraud
Michel Reynaud
Michèle Wessa
Jani Penttilä
Nikoleta Kostogianni
Arnaud Cachia
Eric Artiges
Françoise Delain
Murielle Perrin
Henri-Jean Aubin
Yann Cointepas
Catherine Martelli
Jean-Luc Martinot

DOI

10.1038/npp.2008.101

eISSN

1740-634X

ISSN

0893-133X

Ausgabe der Veröffentlichung

5

Zeitschrift

Neuropsychopharmacology

Sprache

en

Online publication date

2008

Paginierung

1223 - 1232

Datum der Veröffentlichung

2009

Status

Published

Herausgeber

Springer Science and Business Media LLC

Herausgeber URL

http://dx.doi.org/10.1038/npp.2008.101

Datum der Datenerfassung

2023

Titel

Diffusion Tensor Tractography in Mesencephalic Bundles: Relation to Mental Flexibility in Detoxified Alcohol-Dependent Subjects

Ausgabe der Zeitschrift

34

Datenquelle: Crossref

Abstract

Components of the corticocerebellar circuit and the midbrain individually play a central role in addictive processes and have been associated with altered volumes and impairment of cognitive flexibility in alcohol-dependent subjects. The microstructure of white matter bundles composing the corticocerebellar network and passing through the midbrain was studied using diffusion tensor imaging in a group of detoxified alcohol-dependent men (n=20) and a group of healthy men (n=24). The relationship between properties of these white matter bundles and cognitive flexibility performance was investigated in alcohol-dependent subjects. Bundles connecting two regions of interest were analyzed using a fiber-tracking quantitative approach, which provided estimates of the fractional anisotropy and the apparent diffusion coefficient, as well as the number of tracked fibers normalized by the volume of regions of interest. Within the bundles running between the midbrain and pons, a mean of 18% fewer fibers per unit volume were tracked in alcohol-dependent men than in healthy controls. In addition, the normalized number of these fibers correlated with the performance in the Trail-Making Test part-B. Even though the alcohol-dependent subjects were detoxified and apparently neurologically intact, their earlier excessive use of alcohol seems to be associated with altered neural microstructure of mesencephalic white matter bundles, which may contribute to their cognitive flexibility impairment.

Addresses

INSERM, U797 Research Unit Neuroimaging and Psychiatry, IFR49, Orsay, France.

Autoren

Sandra Chanraud
Michel Reynaud
Michèle Wessa
Jani Penttilä
Nikoleta Kostogianni
Arnaud Cachia
Eric Artiges
Françoise Delain
Murielle Perrin
Henri-Jean Aubin
Yann Cointepas
Catherine Martelli
Jean-Luc Martinot

DOI

10.1038/npp.2008.101

eISSN

1740-634X

Externe Identifier

PubMed Identifier: 18615012

Open access

false

ISSN

0893-133X

Ausgabe der Veröffentlichung

5

Zeitschrift

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Schlüsselwörter

Mesencephalon
Cerebellum
Cerebral Cortex
Neural Pathways
Humans
Alcohol-Related Disorders
Imaging, Three-Dimensional
Diffusion Magnetic Resonance Imaging
Cognition
Neuropsychological Tests
Adult
Aged
Middle Aged
Male

Sprache

eng

Medium

Print-Electronic

Online publication date

2008

Paginierung

1223 - 1232

Datum der Veröffentlichung

2009

Status

Published

Datum der Datenerfassung

2008

Titel

Diffusion tensor tractography in mesencephalic bundles: relation to mental flexibility in detoxified alcohol-dependent subjects.

Sub types

Research Support, Non-U.S. Gov't
Journal Article

Ausgabe der Zeitschrift

34

Datenquelle: Europe PubMed Central

Abstract

Components of the corticocerebellar circuit and the midbrain individually play a central role in addictive processes and have been associated with altered volumes and impairment of cognitive flexibility in alcohol-dependent subjects. The microstructure of white matter bundles composing the corticocerebellar network and passing through the midbrain was studied using diffusion tensor imaging in a group of detoxified alcohol-dependent men (n=20) and a group of healthy men (n=24). The relationship between properties of these white matter bundles and cognitive flexibility performance was investigated in alcohol-dependent subjects. Bundles connecting two regions of interest were analyzed using a fiber-tracking quantitative approach, which provided estimates of the fractional anisotropy and the apparent diffusion coefficient, as well as the number of tracked fibers normalized by the volume of regions of interest. Within the bundles running between the midbrain and pons, a mean of 18% fewer fibers per unit volume were tracked in alcohol-dependent men than in healthy controls. In addition, the normalized number of these fibers correlated with the performance in the Trail-Making Test part-B. Even though the alcohol-dependent subjects were detoxified and apparently neurologically intact, their earlier excessive use of alcohol seems to be associated with altered neural microstructure of mesencephalic white matter bundles, which may contribute to their cognitive flexibility impairment.

Autoren

Sandra Chanraud
Michel Reynaud
Michèle Wessa
Jani Penttilä
Nikoleta Kostogianni
Arnaud Cachia
Eric Artiges
Françoise Delain
Murielle Perrin
Henri-Jean Aubin
Yann Cointepas
Catherine Martelli
Jean-Luc Martinot

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/18615012

DOI

10.1038/npp.2008.101

eISSN

1740-634X

Ausgabe der Veröffentlichung

5

Zeitschrift

Neuropsychopharmacology

Schlüsselwörter

Adult
Aged
Alcohol-Related Disorders
Cerebellum
Cerebral Cortex
Cognition
Diffusion Magnetic Resonance Imaging
Humans
Imaging, Three-Dimensional
Male
Mesencephalon
Middle Aged
Neural Pathways
Neuropsychological Tests

Sprache

eng

Country

England

Paginierung

1223 - 1232

PII

npp2008101

Datum der Veröffentlichung

2009

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2009

Titel

Diffusion tensor tractography in mesencephalic bundles: relation to mental flexibility in detoxified alcohol-dependent subjects.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

34

Datenquelle: PubMed

Diffusion Tensor Tractography in Mesencephalic Bundles: Relation to Mental Flexibility in Detoxified Alcohol-Dependent Subjects

Werkzeuge