Loss of callosal fibre integrity in healthy elderly with age-related white matter changes

Autoren

Martin Griebe
Alex Förster
Michèle Wessa
Christina Rossmanith
Hansjörg Bäzner
Tamara Sauer
Kathrin Zohsel
Christian Blahak
Andrea V King
Julia Linke
Michael G Hennerici
Achim Gass
Kristina Szabo

DOI

10.1007/s00415-011-5956-6

eISSN

1432-1459

ISSN

0340-5354

Ausgabe der Veröffentlichung

8

Zeitschrift

Journal of Neurology

Sprache

en

Online publication date

2011

Paginierung

1451 - 1459

Datum der Veröffentlichung

2011

Status

Published

Herausgeber

Springer Science and Business Media LLC

Herausgeber URL

http://dx.doi.org/10.1007/s00415-011-5956-6

Datum der Datenerfassung

2019

Titel

Loss of callosal fibre integrity in healthy elderly with age-related white matter changes

Ausgabe der Zeitschrift

258

Datenquelle: Crossref

Abstract

Age-related white matter changes (ARWMC) appear to correspond to a continuum from normal functioning to clinically overt neurological syndromes. Disturbance of the structural integrity of cerebral fibre tracts-the so-called cerebral network-by ARWMC might be one explanation for this development. From 3 T magnetic resonance imaging (MRI) data of 34 healthy elderly subjects (60-82 years) we calculated the lesion volume of ARWMC and the area of the corpus callosum (CC). Gait, balance and cognition were assessed. We compared these findings in those with mild (n = 22) and advanced (n = 12) ARWMC and performed tract-based spatial statistics (TBSS) to analyze white matter structural integrity. In subjects with advanced ARWMC, TBSS showed a significant decrease of fractional anisotropy (FA) in several large tracts of the white matter including the CC; total CC, CC2 and CC5 areas were significantly smaller. Despite these morphological changes, tests of gait, balance and cognition as measured by the Mini-Mental State Examination (MMSE) were in the normal range for both groups; only the Montreal Cognitive Assessment (MoCA) detected executive and language dysfunction in those with advanced ARWMC. Loss of tissue integrity and atrophy of the CC secondary to spatially remote lesions in the peri- and paraventricular white matter in ARWMC appear to be already detectable in healthy elderly individuals.

Addresses

Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. griebe@neuro.ma.uni-heidelberg.de

Autoren

Martin Griebe
Alex Förster
Michèle Wessa
Christina Rossmanith
Hansjörg Bäzner
Tamara Sauer
Kathrin Zohsel
Christian Blahak
Andrea V King
Julia Linke
Michael G Hennerici
Achim Gass
Kristina Szabo

DOI

10.1007/s00415-011-5956-6

eISSN

1432-1459

Externe Identifier

PubMed Identifier: 21340519

Open access

false

ISSN

0340-5354

Ausgabe der Veröffentlichung

8

Zeitschrift

Journal of neurology

Schlüsselwörter

Cerebral Cortex
Corpus Callosum
Nerve Fibers, Myelinated
Humans
Neuropsychological Tests
Aging
Anisotropy
Aged
Aged, 80 and over
Middle Aged
Female
Male
Diffusion Tensor Imaging

Sprache

eng

Medium

Print-Electronic

Online publication date

2011

Paginierung

1451 - 1459

Datum der Veröffentlichung

2011

Status

Published

Datum der Datenerfassung

2011

Titel

Loss of callosal fibre integrity in healthy elderly with age-related white matter changes.

Sub types

Research Support, Non-U.S. Gov't
Journal Article

Ausgabe der Zeitschrift

258

Datenquelle: Europe PubMed Central

Abstract

Age-related white matter changes (ARWMC) appear to correspond to a continuum from normal functioning to clinically overt neurological syndromes. Disturbance of the structural integrity of cerebral fibre tracts-the so-called cerebral network-by ARWMC might be one explanation for this development. From 3 T magnetic resonance imaging (MRI) data of 34 healthy elderly subjects (60-82 years) we calculated the lesion volume of ARWMC and the area of the corpus callosum (CC). Gait, balance and cognition were assessed. We compared these findings in those with mild (n = 22) and advanced (n = 12) ARWMC and performed tract-based spatial statistics (TBSS) to analyze white matter structural integrity. In subjects with advanced ARWMC, TBSS showed a significant decrease of fractional anisotropy (FA) in several large tracts of the white matter including the CC; total CC, CC2 and CC5 areas were significantly smaller. Despite these morphological changes, tests of gait, balance and cognition as measured by the Mini-Mental State Examination (MMSE) were in the normal range for both groups; only the Montreal Cognitive Assessment (MoCA) detected executive and language dysfunction in those with advanced ARWMC. Loss of tissue integrity and atrophy of the CC secondary to spatially remote lesions in the peri- and paraventricular white matter in ARWMC appear to be already detectable in healthy elderly individuals.

Date of acceptance

2011

Autoren

Martin Griebe
Alex Förster
Michèle Wessa
Christina Rossmanith
Hansjörg Bäzner
Tamara Sauer
Kathrin Zohsel
Christian Blahak
Andrea V King
Julia Linke
Michael G Hennerici
Achim Gass
Kristina Szabo

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/21340519

DOI

10.1007/s00415-011-5956-6

eISSN

1432-1459

Ausgabe der Veröffentlichung

8

Zeitschrift

J Neurol

Schlüsselwörter

Aged
Aged, 80 and over
Aging
Anisotropy
Cerebral Cortex
Corpus Callosum
Diffusion Tensor Imaging
Female
Humans
Male
Middle Aged
Nerve Fibers, Myelinated
Neuropsychological Tests

Sprache

eng

Country

Germany

Paginierung

1451 - 1459

Datum der Veröffentlichung

2011

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2011

Titel

Loss of callosal fibre integrity in healthy elderly with age-related white matter changes.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

258

Datenquelle: PubMed

Loss of callosal fibre integrity in healthy elderly with age-related white matter changes

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