Cortical folding difference between patients with early-onset and patients with intermediate-onset bipolar disorder

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Jani Penttila
  • Arnaud Cachia
  • Jean-Luc Martinot
  • Damien Ringuenet
  • Michele Wessa
  • Josselin Houenou
  • Andre Galinowski
  • Frank Bellivier
  • Thierry Gallarda
  • Edouard Duchesnay
  • Eric Artiges
  • Marion Leboyer
  • Jean-Pierre Olie
  • Jean-Francois Mangin
  • Marie-Laure Paillere-Martinot
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000265934000003&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1111/j.1399-5618.2009.00683.x
eISSN
1399-5618
Externe Identifier
  • Clarivate Analytics Document Solution ID: 443TP
  • PubMed Identifier: 19500089
ISSN
1398-5647
Ausgabe der Veröffentlichung
4
Zeitschrift
BIPOLAR DISORDERS
Schlüsselwörter
  • bipolar disorder
  • magnetic resonance imaging
  • neurodevelopment
  • neuroimaging
Paginierung
361 - 370
Datum der Veröffentlichung
2009
Status
Published
Titel
Cortical folding difference between patients with early-onset and patients with intermediate-onset bipolar disorder
Sub types
  • Article
Ausgabe der Zeitschrift
11

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:p><jats:bold>Objectives: </jats:bold> Cerebral abnormalities have been detected in patients with bipolar disorder (BD). In comparison to BD with a later onset, early‐onset BD has been found to have a poorer outcome. However, it is yet unknown whether neuroanatomical abnormalities differ between age‐at‐onset subgroups of the illness. We searched for cortical folding differences between early‐onset (before 25 years) and intermediate‐onset (between 25 and 45 years) BD patients.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Magnetic resonance images of 22 early‐onset BD patients, 14 intermediate‐onset BD patients, and 50 healthy participants were analyzed using a fully automated method to extract, label, and measure the sulcal area in the whole cortex. Cortical folding was assessed by computing global sulcal indices (the ratio between total sulcal area and total outer cortex area) for each hemisphere, and local sulcal indices for 12 predefined regions in both hemispheres.</jats:p><jats:p><jats:bold>Results: </jats:bold> Intermediate‐onset BD patients had a significantly reduced local sulcal index in the right dorsolateral prefrontal cortex in comparison to both early‐onset BD patients and healthy subjects, and lower global sulcal indices in both hemispheres in comparison to healthy subjects (p &lt; 0.05, Bonferroni corrected). Brain tissue volumes did not differ between groups.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> This study provided the first evidence of a neuroanatomic difference between intermediate‐onset and early‐onset BD, which lends further support to the existence of different age‐at‐onset subgroups of BD.</jats:p>
Autoren
  • Jani Penttilä
  • Arnaud Cachia
  • Jean‐Luc Martinot
  • Damien Ringuenet
  • Michèle Wessa
  • Josselin Houenou
  • André Galinowski
  • Frank Bellivier
  • Thierry Gallarda
  • Edouard Duchesnay
  • Eric Artiges
  • Marion Leboyer
  • Jean‐Pierre Olié
  • Jean‐François Mangin
  • Marie‐Laure Paillère‐Martinot
DOI
10.1111/j.1399-5618.2009.00683.x
eISSN
1399-5618
ISSN
1398-5647
Ausgabe der Veröffentlichung
4
Zeitschrift
Bipolar Disorders
Sprache
en
Online publication date
2009
Paginierung
361 - 370
Datum der Veröffentlichung
2009
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1111/j.1399-5618.2009.00683.x
Datum der Datenerfassung
2023
Titel
Cortical folding difference between patients with early‐onset and patients with intermediate‐onset bipolar disorder
Ausgabe der Zeitschrift
11

Datenquelle: Crossref

Abstract
<h4>Objectives</h4>Cerebral abnormalities have been detected in patients with bipolar disorder (BD). In comparison to BD with a later onset, early-onset BD has been found to have a poorer outcome. However, it is yet unknown whether neuroanatomical abnormalities differ between age-at-onset subgroups of the illness. We searched for cortical folding differences between early-onset (before 25 years) and intermediate-onset (between 25 and 45 years) BD patients.<h4>Methods</h4>Magnetic resonance images of 22 early-onset BD patients, 14 intermediate-onset BD patients, and 50 healthy participants were analyzed using a fully automated method to extract, label, and measure the sulcal area in the whole cortex. Cortical folding was assessed by computing global sulcal indices (the ratio between total sulcal area and total outer cortex area) for each hemisphere, and local sulcal indices for 12 predefined regions in both hemispheres.<h4>Results</h4>Intermediate-onset BD patients had a significantly reduced local sulcal index in the right dorsolateral prefrontal cortex in comparison to both early-onset BD patients and healthy subjects, and lower global sulcal indices in both hemispheres in comparison to healthy subjects (p < 0.05, Bonferroni corrected). Brain tissue volumes did not differ between groups.<h4>Conclusions</h4>This study provided the first evidence of a neuroanatomic difference between intermediate-onset and early-onset BD, which lends further support to the existence of different age-at-onset subgroups of BD.
Addresses
  • INSERM, U797 Research Unit Neuroimaging and Psychiatry, France. japepe@utu.fi
Autoren
  • Jani Penttilä
  • Arnaud Cachia
  • Jean-Luc Martinot
  • Damien Ringuenet
  • Michèle Wessa
  • Josselin Houenou
  • André Galinowski
  • Frank Bellivier
  • Thierry Gallarda
  • Edouard Duchesnay
  • Eric Artiges
  • Marion Leboyer
  • Jean-Pierre Olié
  • Jean-François Mangin
  • Marie-Laure Paillère-Martinot
DOI
10.1111/j.1399-5618.2009.00683.x
eISSN
1399-5618
Externe Identifier
  • PubMed Identifier: 19500089
Open access
false
ISSN
1398-5647
Ausgabe der Veröffentlichung
4
Zeitschrift
Bipolar disorders
Schlüsselwörter
  • Cerebral Cortex
  • Humans
  • Imaging, Three-Dimensional
  • Brain Mapping
  • Suicide, Attempted
  • Bipolar Disorder
  • Age Factors
  • Age of Onset
  • Adult
  • Middle Aged
  • Female
  • Male
  • Functional Laterality
Sprache
eng
Medium
Print
Paginierung
361 - 370
Datum der Veröffentlichung
2009
Status
Published
Datum der Datenerfassung
2009
Titel
Cortical folding difference between patients with early-onset and patients with intermediate-onset bipolar disorder.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
11

Datenquelle: Europe PubMed Central

Abstract
OBJECTIVES: Cerebral abnormalities have been detected in patients with bipolar disorder (BD). In comparison to BD with a later onset, early-onset BD has been found to have a poorer outcome. However, it is yet unknown whether neuroanatomical abnormalities differ between age-at-onset subgroups of the illness. We searched for cortical folding differences between early-onset (before 25 years) and intermediate-onset (between 25 and 45 years) BD patients. METHODS: Magnetic resonance images of 22 early-onset BD patients, 14 intermediate-onset BD patients, and 50 healthy participants were analyzed using a fully automated method to extract, label, and measure the sulcal area in the whole cortex. Cortical folding was assessed by computing global sulcal indices (the ratio between total sulcal area and total outer cortex area) for each hemisphere, and local sulcal indices for 12 predefined regions in both hemispheres. RESULTS: Intermediate-onset BD patients had a significantly reduced local sulcal index in the right dorsolateral prefrontal cortex in comparison to both early-onset BD patients and healthy subjects, and lower global sulcal indices in both hemispheres in comparison to healthy subjects (p < 0.05, Bonferroni corrected). Brain tissue volumes did not differ between groups. CONCLUSIONS: This study provided the first evidence of a neuroanatomic difference between intermediate-onset and early-onset BD, which lends further support to the existence of different age-at-onset subgroups of BD.
Autoren
  • Jani Penttilä
  • Arnaud Cachia
  • Jean-Luc Martinot
  • Damien Ringuenet
  • Michèle Wessa
  • Josselin Houenou
  • André Galinowski
  • Frank Bellivier
  • Thierry Gallarda
  • Edouard Duchesnay
  • Eric Artiges
  • Marion Leboyer
  • Jean-Pierre Olié
  • Jean-François Mangin
  • Marie-Laure Paillère-Martinot
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/19500089
DOI
10.1111/j.1399-5618.2009.00683.x
eISSN
1399-5618
Ausgabe der Veröffentlichung
4
Zeitschrift
Bipolar Disord
Schlüsselwörter
  • Adult
  • Age Factors
  • Age of Onset
  • Bipolar Disorder
  • Brain Mapping
  • Cerebral Cortex
  • Female
  • Functional Laterality
  • Humans
  • Imaging, Three-Dimensional
  • Male
  • Middle Aged
  • Suicide, Attempted
Sprache
eng
Country
Denmark
Paginierung
361 - 370
PII
BDI683
Datum der Veröffentlichung
2009
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2009
Titel
Cortical folding difference between patients with early-onset and patients with intermediate-onset bipolar disorder.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
11

Datenquelle: PubMed

Beziehungen:
Eigentum von

Werkzeuge