Fronto-striatal overactivation in euthymic bipolar patients during an emotional Go/NoGo task
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Michele Wessa
- Josselin Houenou
- Marie-Laure Paillere-Martinot
- Sylvie Berthoz
- Eric Artiges
- Marion Leboyer
- Jean-Luc Martinot
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000245402600019&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1176/appi.ajp.164.4.638
- eISSN
- 1535-7228
- Externe Identifier
- Clarivate Analytics Document Solution ID: 152ZZ
- PubMed Identifier: 17403978
- ISSN
- 0002-953X
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- AMERICAN JOURNAL OF PSYCHIATRY
- Paginierung
- 638 - 646
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Titel
- Fronto-striatal overactivation in euthymic bipolar patients during an emotional Go/NoGo task
- Sub types
- Article
- Ausgabe der Zeitschrift
- 164
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Michèle Wessa
- Josselin Houenou
- Marie-Laure Paillère-Martinot
- Sylvie Berthoz
- Eric Artiges
- Marion Leboyer
- Jean-Luc Martinot
- DOI
- 10.1176/ajp.2007.164.4.638
- eISSN
- 1535-7228
- ISSN
- 0002-953X
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- American Journal of Psychiatry
- Sprache
- en
- Paginierung
- 638 - 646
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Herausgeber
- American Psychiatric Association Publishing
- Herausgeber URL
- http://dx.doi.org/10.1176/ajp.2007.164.4.638
- Datum der Datenerfassung
- 2024
- Titel
- Fronto-Striatal Overactivation in Euthymic Bipolar Patients During an Emotional Go/NoGo Task
- Ausgabe der Zeitschrift
- 164
Datenquelle: Crossref
- Abstract
- <h4>Objective</h4>Although euthymic bipolar patients show minimal manic and depressive symptoms, they continue to show impaired emotional regulation and cognitive functioning. Few studies have directly examined the interference of emotional information with cognitive processes and its underlying cerebral mechanisms in euthymic bipolar patients. The authors examined the emotional modulation of cognitive processes and its underlying neural mechanisms in euthymic bipolar patients.<h4>Method</h4>Seventeen euthymic bipolar patients and 17 healthy comparison subjects underwent functional magnetic resonance imaging (MRI) while performing an emotional and nonemotional go/nogo task. Neural responses associated with the overall task performance, as well as with the impact of emotional information on the task performance, were assessed.<h4>Results</h4>Bipolar disorder patients exhibited increased activity in the temporal cortex, specifically to emotional go/nogo conditions, as well as in the orbitofrontal cortex, the insula, the caudate nuclei, and the dorsal anterior and posterior cingulate cortices when inhibiting emotional stimuli compared with neutral stimuli. Conversely, no global attentional deficits were observed on either a behavioral or neural response level, indicated by similar task performances for all task conditions and similar brain activation patterns when comparing all the go/nogo conditions with the resting state.<h4>Conclusions</h4>The present study provides evidence of an altered emotional modulation of cognitive processing in euthymic bipolar patients, indicated by an overactivation in ventral-limbic, temporal, and dorsal brain structures during emotional go/nogo conditions in patients relative to comparison subjects.
- Addresses
- Inserm U797, CEA-INSERM Research Unit Neuroimaging and Psychiatry, IFR49, University Paris-Sud 11 and University Paris 5, Hospital Department Frédéric Joliot, 91401 Orsay, France. michele.wessa@zi-mannheim.de
- Autoren
- Michèle Wessa
- Josselin Houenou
- Marie-Laure Paillère-Martinot
- Sylvie Berthoz
- Eric Artiges
- Marion Leboyer
- Jean-Luc Martinot
- DOI
- 10.1176/ajp.2007.164.4.638
- eISSN
- 1535-7228
- Externe Identifier
- PubMed Identifier: 17403978
- Open access
- false
- ISSN
- 0002-953X
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- The American journal of psychiatry
- Schlüsselwörter
- Limbic System
- Basal Ganglia
- Frontal Lobe
- Humans
- Magnetic Resonance Imaging
- Facial Expression
- Brain Mapping
- Emotions
- Cognition
- Task Performance and Analysis
- Psychomotor Performance
- Reaction Time
- Bipolar Disorder
- Adult
- Female
- Male
- Sprache
- eng
- Medium
- Paginierung
- 638 - 646
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Datum der Datenerfassung
- 2007
- Titel
- Fronto-striatal overactivation in euthymic bipolar patients during an emotional go/nogo task.
- Sub types
- Comparative Study
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 164
Datenquelle: Europe PubMed Central
- Abstract
- OBJECTIVE: Although euthymic bipolar patients show minimal manic and depressive symptoms, they continue to show impaired emotional regulation and cognitive functioning. Few studies have directly examined the interference of emotional information with cognitive processes and its underlying cerebral mechanisms in euthymic bipolar patients. The authors examined the emotional modulation of cognitive processes and its underlying neural mechanisms in euthymic bipolar patients. METHOD: Seventeen euthymic bipolar patients and 17 healthy comparison subjects underwent functional magnetic resonance imaging (MRI) while performing an emotional and nonemotional go/nogo task. Neural responses associated with the overall task performance, as well as with the impact of emotional information on the task performance, were assessed. RESULTS: Bipolar disorder patients exhibited increased activity in the temporal cortex, specifically to emotional go/nogo conditions, as well as in the orbitofrontal cortex, the insula, the caudate nuclei, and the dorsal anterior and posterior cingulate cortices when inhibiting emotional stimuli compared with neutral stimuli. Conversely, no global attentional deficits were observed on either a behavioral or neural response level, indicated by similar task performances for all task conditions and similar brain activation patterns when comparing all the go/nogo conditions with the resting state. CONCLUSIONS: The present study provides evidence of an altered emotional modulation of cognitive processing in euthymic bipolar patients, indicated by an overactivation in ventral-limbic, temporal, and dorsal brain structures during emotional go/nogo conditions in patients relative to comparison subjects.
- Autoren
- Michèle Wessa
- Josselin Houenou
- Marie-Laure Paillère-Martinot
- Sylvie Berthoz
- Eric Artiges
- Marion Leboyer
- Jean-Luc Martinot
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/17403978
- DOI
- 10.1176/ajp.2007.164.4.638
- ISSN
- 0002-953X
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Am J Psychiatry
- Schlüsselwörter
- Adult
- Basal Ganglia
- Bipolar Disorder
- Brain Mapping
- Cognition
- Emotions
- Facial Expression
- Female
- Frontal Lobe
- Humans
- Limbic System
- Magnetic Resonance Imaging
- Male
- Psychomotor Performance
- Reaction Time
- Task Performance and Analysis
- Sprache
- eng
- Country
- United States
- Paginierung
- 638 - 646
- PII
- 164/4/638
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2007
- Titel
- Fronto-striatal overactivation in euthymic bipolar patients during an emotional go/nogo task.
- Sub types
- Comparative Study
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 164
Datenquelle: PubMed
- Beziehungen:
- Eigentum von