Microstructure of a three-way anatomical network predicts individual differences in response inhibition: A tractography study
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Andrea V King
- Julia Linke
- Achim Gass
- Michael G Hennerici
- Heike Tost
- Cyril Poupon
- Michele Wessa
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000298210600118&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.neuroimage.2011.09.008
- Externe Identifier
- Clarivate Analytics Document Solution ID: 864AY
- PubMed Identifier: 21939775
- ISSN
- 1053-8119
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- NEUROIMAGE
- Schlüsselwörter
- Response inhibition
- DTI
- Tractography
- Inferior frontal gyrus
- Presupplementary motor area
- Basal ganglia
- Paginierung
- 1949 - 1959
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Titel
- Microstructure of a three-way anatomical network predicts individual differences in response inhibition: A tractography study
- Sub types
- Article
- Ausgabe der Zeitschrift
- 59
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Andrea V King
- Julia Linke
- Achim Gass
- Michael G Hennerici
- Heike Tost
- Cyril Poupon
- Michèle Wessa
- DOI
- 10.1016/j.neuroimage.2011.09.008
- ISSN
- 1053-8119
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- NeuroImage
- Sprache
- en
- Paginierung
- 1949 - 1959
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.neuroimage.2011.09.008
- Datum der Datenerfassung
- 2020
- Titel
- Microstructure of a three-way anatomical network predicts individual differences in response inhibition: A tractography study
- Ausgabe der Zeitschrift
- 59
Datenquelle: Crossref
- Abstract
- Response inhibition is thought to depend critically on the inferior frontal gyrus, pars opercularis (IFGoper), presupplementary motor area (preSMA) and basal ganglia, including the subthalamic nucleus (STN), but the differential contribution of structural connections within this network to response inhibition remains unclear. Using diffusion tensor imaging and probabilistic fiber tractography, we investigated the relative associations between local white matter microstructure and stop-signal response inhibition in fronto-basal ganglia tracts delineated by probabilistic tractography. In a tract-of-interest approach, we identify significant associations with fractional anisotropy (FA) in fibers connecting the right STN region to both preSMA/SMA and IFGoper and in bilateral tracts connecting preSMA/SMA to IFGoper and the striatum. In addition, significant associations with radial diffusivity (RD) were found in fibers connecting the right preSMA/SMA to striatum and in bilateral tracts between IFGoper and STN region. In our whole-brain analysis, additional significant clusters were identified in the corpus callosum, optic radiation, inferior fronto-occipital tract and white matter of the precentral gyrus. To investigate the relative importance of regional white matter characteristics to response inhibition performance, we performed a step-wise multiple regression analysis that yielded FA in tracts connecting preSMA/SMA to the STN region and striatum, respectively, and RD in fibers connecting IFGoper to the STN region as best predictors of response inhibition performance (42% explained variance). These findings point to a specific contribution of white matter pathways connecting distinct basal ganglia structures with both medial frontal and ventrolateral prefrontal regions to response inhibition.
- Addresses
- Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, University of Heidelberg, Square J5, 68159 Mannheim, Germany. andrea.v.king@aol.com
- Autoren
- Andrea V King
- Julia Linke
- Achim Gass
- Michael G Hennerici
- Heike Tost
- Cyril Poupon
- Michèle Wessa
- DOI
- 10.1016/j.neuroimage.2011.09.008
- eISSN
- 1095-9572
- Externe Identifier
- PubMed Identifier: 21939775
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft (DFG):
- Open access
- false
- ISSN
- 1053-8119
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- NeuroImage
- Schlüsselwörter
- Brain
- Nerve Net
- Nerve Fibers, Myelinated
- Humans
- Neural Inhibition
- Adult
- Female
- Male
- Young Adult
- Diffusion Tensor Imaging
- Inhibition, Psychological
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2011
- Paginierung
- 1949 - 1959
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum der Datenerfassung
- 2011
- Titel
- Microstructure of a three-way anatomical network predicts individual differences in response inhibition: a tractography study.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 59
Datenquelle: Europe PubMed Central
- Abstract
- Response inhibition is thought to depend critically on the inferior frontal gyrus, pars opercularis (IFGoper), presupplementary motor area (preSMA) and basal ganglia, including the subthalamic nucleus (STN), but the differential contribution of structural connections within this network to response inhibition remains unclear. Using diffusion tensor imaging and probabilistic fiber tractography, we investigated the relative associations between local white matter microstructure and stop-signal response inhibition in fronto-basal ganglia tracts delineated by probabilistic tractography. In a tract-of-interest approach, we identify significant associations with fractional anisotropy (FA) in fibers connecting the right STN region to both preSMA/SMA and IFGoper and in bilateral tracts connecting preSMA/SMA to IFGoper and the striatum. In addition, significant associations with radial diffusivity (RD) were found in fibers connecting the right preSMA/SMA to striatum and in bilateral tracts between IFGoper and STN region. In our whole-brain analysis, additional significant clusters were identified in the corpus callosum, optic radiation, inferior fronto-occipital tract and white matter of the precentral gyrus. To investigate the relative importance of regional white matter characteristics to response inhibition performance, we performed a step-wise multiple regression analysis that yielded FA in tracts connecting preSMA/SMA to the STN region and striatum, respectively, and RD in fibers connecting IFGoper to the STN region as best predictors of response inhibition performance (42% explained variance). These findings point to a specific contribution of white matter pathways connecting distinct basal ganglia structures with both medial frontal and ventrolateral prefrontal regions to response inhibition.
- Date of acceptance
- 2011
- Autoren
- Andrea V King
- Julia Linke
- Achim Gass
- Michael G Hennerici
- Heike Tost
- Cyril Poupon
- Michèle Wessa
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/21939775
- DOI
- 10.1016/j.neuroimage.2011.09.008
- eISSN
- 1095-9572
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Neuroimage
- Schlüsselwörter
- Adult
- Brain
- Diffusion Tensor Imaging
- Female
- Humans
- Inhibition, Psychological
- Male
- Nerve Fibers, Myelinated
- Nerve Net
- Neural Inhibition
- Young Adult
- Sprache
- eng
- Country
- United States
- Paginierung
- 1949 - 1959
- PII
- S1053-8119(11)01047-0
- Datum der Veröffentlichung
- 2012
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- Microstructure of a three-way anatomical network predicts individual differences in response inhibition: a tractography study.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 59
Datenquelle: PubMed
- Beziehungen:
- Eigentum von