Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Simone Lang
- Alexander Kroll
- Slawomira J Lipinski
- Michele Wessa
- Stephanie Ridder
- Christoph Christmann
- Lothar R Schad
- Herta Flor
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000263451700017&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1111/j.1460-9568.2009.06624.x
- eISSN
- 1460-9568
- Externe Identifier
- Clarivate Analytics Document Solution ID: 408RF
- PubMed Identifier: 19200075
- ISSN
- 0953-816X
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- EUROPEAN JOURNAL OF NEUROSCIENCE
- Schlüsselwörter
- anxiety
- fear learning
- functional connectivity
- functional magnetic resonance imaging (fMRI)
- Paginierung
- 823 - 832
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Titel
- Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex
- Sub types
- Article
- Ausgabe der Zeitschrift
- 29
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>Functional magnetic resonance imaging was used to investigate the role of the hippocampus, amygdala and medial prefrontal cortex (mPFC) in a contextual conditioning and extinction paradigm provoking anxiety. Twenty‐one healthy persons participated in a differential context conditioning procedure with two different background colours as contexts. During acquisition increased activity to the conditioned stimulus (CS+) relative to the CS− was found in the left hippocampus and anterior cingulate cortex (ACC). The amygdala, insula and inferior frontal cortex were differentially active during late acquisition. Extinction was accompanied by enhanced activation to CS+ vs. CS− in the dorsal anterior cingulate cortex (dACC). The results are in accordance with animal studies and provide evidence for the important role of the hippocampus in contextual learning in humans. Connectivity analyses revealed correlated activity between the left posterior hippocampus and dACC (BA32) during early acquisition and the dACC, left posterior hippocampus and right amygdala during extinction. These data are consistent with theoretical models that propose an inhibitory effect of the mPFC on the amygdala. The interaction of the mPFC with the hippocampus may reflect the context‐specificity of extinction learning.</jats:p>
- Autoren
- Simone Lang
- Alexander Kroll
- Slawomira J Lipinski
- Michèle Wessa
- Stephanie Ridder
- Christoph Christmann
- Lothar R Schad
- Herta Flor
- DOI
- 10.1111/j.1460-9568.2009.06624.x
- eISSN
- 1460-9568
- ISSN
- 0953-816X
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- European Journal of Neuroscience
- Sprache
- en
- Online publication date
- 2009
- Paginierung
- 823 - 832
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Herausgeber
- Wiley
- Herausgeber URL
- http://dx.doi.org/10.1111/j.1460-9568.2009.06624.x
- Datum der Datenerfassung
- 2023
- Titel
- Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex
- Ausgabe der Zeitschrift
- 29
Datenquelle: Crossref
- Abstract
- Functional magnetic resonance imaging was used to investigate the role of the hippocampus, amygdala and medial prefrontal cortex (mPFC) in a contextual conditioning and extinction paradigm provoking anxiety. Twenty-one healthy persons participated in a differential context conditioning procedure with two different background colours as contexts. During acquisition increased activity to the conditioned stimulus (CS+) relative to the CS- was found in the left hippocampus and anterior cingulate cortex (ACC). The amygdala, insula and inferior frontal cortex were differentially active during late acquisition. Extinction was accompanied by enhanced activation to CS+ vs. CS- in the dorsal anterior cingulate cortex (dACC). The results are in accordance with animal studies and provide evidence for the important role of the hippocampus in contextual learning in humans. Connectivity analyses revealed correlated activity between the left posterior hippocampus and dACC (BA32) during early acquisition and the dACC, left posterior hippocampus and right amygdala during extinction. These data are consistent with theoretical models that propose an inhibitory effect of the mPFC on the amygdala. The interaction of the mPFC with the hippocampus may reflect the context-specificity of extinction learning.
- Addresses
- Department of Clinical and Cognitive Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
- Autoren
- Simone Lang
- Alexander Kroll
- Slawomira J Lipinski
- Michèle Wessa
- Stephanie Ridder
- Christoph Christmann
- Lothar R Schad
- Herta Flor
- DOI
- 10.1111/j.1460-9568.2009.06624.x
- eISSN
- 1460-9568
- Externe Identifier
- PubMed Identifier: 19200075
- PubMed Central ID: PMC2695154
- Open access
- true
- ISSN
- 0953-816X
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- The European journal of neuroscience
- Schlüsselwörter
- Amygdala
- Hippocampus
- Cerebral Cortex
- Prefrontal Cortex
- Neural Pathways
- Humans
- Magnetic Resonance Imaging
- Regression Analysis
- Electric Stimulation
- Photic Stimulation
- Cues
- Galvanic Skin Response
- Adult
- Female
- Male
- Extinction, Psychological
- Young Adult
- Conditioning, Psychological
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2008
- Open access status
- Open Access
- Paginierung
- 823 - 832
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2009
- Titel
- Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 29
Files
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1460-9568.2009.06624.x https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19200075/pdf/?tool=EBI https://europepmc.org/articles/PMC2695154?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Functional magnetic resonance imaging was used to investigate the role of the hippocampus, amygdala and medial prefrontal cortex (mPFC) in a contextual conditioning and extinction paradigm provoking anxiety. Twenty-one healthy persons participated in a differential context conditioning procedure with two different background colours as contexts. During acquisition increased activity to the conditioned stimulus (CS+) relative to the CS- was found in the left hippocampus and anterior cingulate cortex (ACC). The amygdala, insula and inferior frontal cortex were differentially active during late acquisition. Extinction was accompanied by enhanced activation to CS+ vs. CS- in the dorsal anterior cingulate cortex (dACC). The results are in accordance with animal studies and provide evidence for the important role of the hippocampus in contextual learning in humans. Connectivity analyses revealed correlated activity between the left posterior hippocampus and dACC (BA32) during early acquisition and the dACC, left posterior hippocampus and right amygdala during extinction. These data are consistent with theoretical models that propose an inhibitory effect of the mPFC on the amygdala. The interaction of the mPFC with the hippocampus may reflect the context-specificity of extinction learning.
- Autoren
- Simone Lang
- Alexander Kroll
- Slawomira J Lipinski
- Michèle Wessa
- Stephanie Ridder
- Christoph Christmann
- Lothar R Schad
- Herta Flor
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/19200075
- DOI
- 10.1111/j.1460-9568.2009.06624.x
- eISSN
- 1460-9568
- Externe Identifier
- PubMed Central ID: PMC2695154
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Eur J Neurosci
- Schlüsselwörter
- Adult
- Amygdala
- Cerebral Cortex
- Conditioning, Psychological
- Cues
- Electric Stimulation
- Extinction, Psychological
- Female
- Galvanic Skin Response
- Hippocampus
- Humans
- Magnetic Resonance Imaging
- Male
- Neural Pathways
- Photic Stimulation
- Prefrontal Cortex
- Regression Analysis
- Young Adult
- Sprache
- eng
- Country
- France
- Paginierung
- 823 - 832
- PII
- EJN6624
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2009
- Titel
- Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 29
Datenquelle: PubMed
- Beziehungen:
- Eigentum von