Brain activation during fear conditioning in humans depends on genetic variations related to functioning of the hypothalamic-pituitary-adrenal axis: first evidence from two independent subsamples

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • S Ridder
  • J Treutlein
  • F Nees
  • S Lang
  • S Diener
  • M Wessa
  • A Kroll
  • S Pohlack
  • R Cacciaglia
  • P Gass
  • G Schuetz
  • G Schumann
  • H Flor
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000310629600008&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1017/S0033291712000359
eISSN
1469-8978
Externe Identifier
  • Clarivate Analytics Document Solution ID: 031HI
  • PubMed Identifier: 22410078
ISSN
0033-2917
Ausgabe der Veröffentlichung
11
Zeitschrift
PSYCHOLOGICAL MEDICINE
Schlüsselwörter
  • Fear conditioning
  • functional magnetic resonance imaging
  • genes
  • hypothalamic-pituitary-adrenal axis
  • PTSD
Paginierung
2325 - 2335
Datum der Veröffentlichung
2012
Status
Published
Titel
Brain activation during fear conditioning in humans depends on genetic variations related to functioning of the hypothalamic-pituitary-adrenal axis: first evidence from two independent subsamples
Sub types
  • Article
Ausgabe der Zeitschrift
42

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:sec id="S0033291712000359_sec_a001"><jats:title>Background</jats:title><jats:p>Enhanced acquisition and delayed extinction of fear conditioning are viewed as major determinants of anxiety disorders, which are often characterized by a dysfunctional hypothalamic–pituitary–adrenal (HPA) axis.</jats:p></jats:sec><jats:sec id="S0033291712000359_sec_a002"><jats:title>Method</jats:title><jats:p>In this study we employed cued fear conditioning in two independent samples of healthy subjects (sample 1:<jats:italic>n</jats:italic>=60, sample 2:<jats:italic>n</jats:italic>=52). Two graphical shapes served as conditioned stimuli and painful electrical stimulation as the unconditioned stimulus. In addition, guided by findings from published animal studies on HPA axis-related genes in fear conditioning, we examined variants of the glucocorticoid receptor and corticotropin-releasing hormone receptor 1 genes.</jats:p></jats:sec><jats:sec id="S0033291712000359_sec_a003" sec-type="results"><jats:title>Results</jats:title><jats:p>Variation in these genes showed enhanced amygdala activation during the acquisition and reduced prefrontal activation during the extinction of fear as well as altered amygdala–prefrontal connectivity.</jats:p></jats:sec><jats:sec id="S0033291712000359_sec_a004" sec-type="conclusion"><jats:title>Conclusions</jats:title><jats:p>This is the first demonstration of the involvement of genes related to the HPA axis in human fear conditioning.</jats:p></jats:sec>
Autoren
  • S Ridder
  • J Treutlein
  • F Nees
  • S Lang
  • S Diener
  • M Wessa
  • A Kroll
  • S Pohlack
  • R Cacciaglia
  • P Gass
  • G Schütz
  • G Schumann
  • H Flor
DOI
10.1017/s0033291712000359
eISSN
1469-8978
ISSN
0033-2917
Ausgabe der Veröffentlichung
11
Zeitschrift
Psychological Medicine
Sprache
en
Online publication date
2012
Paginierung
2325 - 2335
Datum der Veröffentlichung
2012
Status
Published
Herausgeber
Cambridge University Press (CUP)
Herausgeber URL
http://dx.doi.org/10.1017/s0033291712000359
Datum der Datenerfassung
2023
Titel
Brain activation during fear conditioning in humans depends on genetic variations related to functioning of the hypothalamic–pituitary–adrenal axis: first evidence from two independent subsamples
Ausgabe der Zeitschrift
42

Datenquelle: Crossref

Abstract
<h4>Background</h4>Enhanced acquisition and delayed extinction of fear conditioning are viewed as major determinants of anxiety disorders, which are often characterized by a dysfunctional hypothalamic-pituitary-adrenal (HPA) axis.<h4>Method</h4>In this study we employed cued fear conditioning in two independent samples of healthy subjects (sample 1: n=60, sample 2: n=52). Two graphical shapes served as conditioned stimuli and painful electrical stimulation as the unconditioned stimulus. In addition, guided by findings from published animal studies on HPA axis-related genes in fear conditioning, we examined variants of the glucocorticoid receptor and corticotropin-releasing hormone receptor 1 genes.<h4>Results</h4>Variation in these genes showed enhanced amygdala activation during the acquisition and reduced prefrontal activation during the extinction of fear as well as altered amygdala-prefrontal connectivity.<h4>Conclusions</h4>This is the first demonstration of the involvement of genes related to the HPA axis in human fear conditioning.
Addresses
  • Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Autoren
  • S Ridder
  • J Treutlein
  • F Nees
  • S Lang
  • S Diener
  • M Wessa
  • A Kroll
  • S Pohlack
  • R Cacciaglia
  • P Gass
  • G Schütz
  • G Schumann
  • H Flor
DOI
10.1017/s0033291712000359
eISSN
1469-8978
Externe Identifier
  • PubMed Identifier: 22410078
  • PubMed Central ID: PMC3466052
Open access
true
ISSN
0033-2917
Ausgabe der Veröffentlichung
11
Zeitschrift
Psychological medicine
Schlüsselwörter
  • Pituitary-Adrenal System
  • Hypothalamo-Hypophyseal System
  • Amygdala
  • Prefrontal Cortex
  • Nerve Net
  • Humans
  • Receptors, Corticotropin-Releasing Hormone
  • Receptors, Glucocorticoid
  • Magnetic Resonance Imaging
  • Fear
  • Conditioning, Classical
  • Adolescent
  • Adult
  • Female
  • Male
  • Extinction, Psychological
  • Young Adult
  • Functional Neuroimaging
Sprache
eng
Medium
Print-Electronic
Online publication date
2012
Open access status
Open Access
Paginierung
2325 - 2335
Datum der Veröffentlichung
2012
Status
Published
Publisher licence
CC BY-NC-SA
Datum der Datenerfassung
2012
Titel
Brain activation during fear conditioning in humans depends on genetic variations related to functioning of the hypothalamic-pituitary-adrenal axis: first evidence from two independent subsamples.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
42

Files

https://www.cambridge.org/core/services/aop-cambridge-core/content/view/71D211CD1FF0F8C39D852706F64B748B/S0033291712000359a.pdf/div-class-title-brain-activation-during-fear-conditioning-in-humans-depends-on-genetic-variations-related-to-functioning-of-the-hypothalamic-pituitary-adrenal-axis-first-evidence-from-two-independent-subsamples-div.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22410078/pdf/?tool=EBI https://europepmc.org/articles/PMC3466052?pdf=render

Datenquelle: Europe PubMed Central

Abstract
BACKGROUND: Enhanced acquisition and delayed extinction of fear conditioning are viewed as major determinants of anxiety disorders, which are often characterized by a dysfunctional hypothalamic-pituitary-adrenal (HPA) axis. METHOD: In this study we employed cued fear conditioning in two independent samples of healthy subjects (sample 1: n=60, sample 2: n=52). Two graphical shapes served as conditioned stimuli and painful electrical stimulation as the unconditioned stimulus. In addition, guided by findings from published animal studies on HPA axis-related genes in fear conditioning, we examined variants of the glucocorticoid receptor and corticotropin-releasing hormone receptor 1 genes. RESULTS: Variation in these genes showed enhanced amygdala activation during the acquisition and reduced prefrontal activation during the extinction of fear as well as altered amygdala-prefrontal connectivity. CONCLUSIONS: This is the first demonstration of the involvement of genes related to the HPA axis in human fear conditioning.
Autoren
  • S Ridder
  • J Treutlein
  • F Nees
  • S Lang
  • S Diener
  • M Wessa
  • A Kroll
  • S Pohlack
  • R Cacciaglia
  • P Gass
  • G Schütz
  • G Schumann
  • H Flor
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/22410078
DOI
10.1017/S0033291712000359
eISSN
1469-8978
Externe Identifier
  • PubMed Central ID: PMC3466052
Ausgabe der Veröffentlichung
11
Zeitschrift
Psychol Med
Schlüsselwörter
  • Adolescent
  • Adult
  • Amygdala
  • Conditioning, Classical
  • Extinction, Psychological
  • Fear
  • Female
  • Functional Neuroimaging
  • Humans
  • Hypothalamo-Hypophyseal System
  • Magnetic Resonance Imaging
  • Male
  • Nerve Net
  • Pituitary-Adrenal System
  • Prefrontal Cortex
  • Receptors, Corticotropin-Releasing Hormone
  • Receptors, Glucocorticoid
  • Young Adult
Sprache
eng
Country
England
Paginierung
2325 - 2335
PII
S0033291712000359
Datum der Veröffentlichung
2012
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2015
Titel
Brain activation during fear conditioning in humans depends on genetic variations related to functioning of the hypothalamic-pituitary-adrenal axis: first evidence from two independent subsamples.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
42

Datenquelle: PubMed

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