Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

Autoren

J Houenou
M Wessa
G Douaud
M Leboyer
S Chanraud
M Perrin
C Poupon
J-L Martinot
M-L Paillere-Martinot

DOI

10.1038/sj.mp.4002010

eISSN

1476-5578

ISSN

1359-4184

Ausgabe der Veröffentlichung

11

Zeitschrift

Molecular Psychiatry

Sprache

en

Online publication date

2007

Paginierung

1001 - 1010

Datum der Veröffentlichung

2007

Status

Published

Herausgeber

Springer Science and Business Media LLC

Herausgeber URL

http://dx.doi.org/10.1038/sj.mp.4002010

Datum der Datenerfassung

2023

Titel

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

Ausgabe der Zeitschrift

12

Datenquelle: Crossref

Abstract

Bipolar disorder has been associated with anatomical as well as functional abnormalities in a brain network that mediates normal and impaired emotion regulation. Previous brain imaging studies have highlighted the subgenual cingulate (SC) and the amygdalo-hippocampal (AH) complex as core regions of this network. Thus we investigated white matter (WM) fiber tracts between the SC and the AH region, the uncinate fasciculus, as well as between two control regions (pons and cerebellum), using diffusion tensor imaging tractography in 16 euthymic bipolar patients (BP) and 16 sex-, age- and handedness-matched controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the reconstructed fiber bundle and the number of virtual reconstructed fibers were compared between groups. The tractography results revealed a significantly increased number of reconstructed fibers between the left SC and left AH in BP as compared to healthy controls. FA and ADC of the reconstructed fiber tract did not differ significantly between the groups. Furthermore, no significant group differences were observed neither for reconstructed fiber tracts between the right SC and right AH nor between the control regions. The present results suggest an altered WM pathway between the left SC and AH region and thus extend previous findings of anatomical and functional modifications in these structures in BP.

Addresses

INSERM, U797, Research Unit Neuroimaging and Psychiatry, IFR49, Orsay, France.

Autoren

J Houenou
M Wessa
G Douaud
M Leboyer
S Chanraud
M Perrin
C Poupon
J-L Martinot
M-L Paillere-Martinot

DOI

10.1038/sj.mp.4002010

eISSN

1476-5578

Externe Identifier

PubMed Identifier: 17471288

Open access

false

ISSN

1359-4184

Ausgabe der Veröffentlichung

11

Zeitschrift

Molecular psychiatry

Schlüsselwörter

Amygdala
Gyrus Cinguli
Hippocampus
Neural Pathways
Humans
Diffusion Magnetic Resonance Imaging
Brain Mapping
Bipolar Disorder
Adult
Middle Aged
Female
Male

Sprache

eng

Medium

Print-Electronic

Online publication date

2007

Paginierung

1001 - 1010

Datum der Veröffentlichung

2007

Status

Published

Datum der Datenerfassung

2007

Titel

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex.

Sub types

Research Support, Non-U.S. Gov't
Journal Article

Ausgabe der Zeitschrift

12

Datenquelle: Europe PubMed Central

Abstract

Bipolar disorder has been associated with anatomical as well as functional abnormalities in a brain network that mediates normal and impaired emotion regulation. Previous brain imaging studies have highlighted the subgenual cingulate (SC) and the amygdalo-hippocampal (AH) complex as core regions of this network. Thus we investigated white matter (WM) fiber tracts between the SC and the AH region, the uncinate fasciculus, as well as between two control regions (pons and cerebellum), using diffusion tensor imaging tractography in 16 euthymic bipolar patients (BP) and 16 sex-, age- and handedness-matched controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the reconstructed fiber bundle and the number of virtual reconstructed fibers were compared between groups. The tractography results revealed a significantly increased number of reconstructed fibers between the left SC and left AH in BP as compared to healthy controls. FA and ADC of the reconstructed fiber tract did not differ significantly between the groups. Furthermore, no significant group differences were observed neither for reconstructed fiber tracts between the right SC and right AH nor between the control regions. The present results suggest an altered WM pathway between the left SC and AH region and thus extend previous findings of anatomical and functional modifications in these structures in BP.

Autoren

J Houenou
M Wessa
G Douaud
M Leboyer
S Chanraud
M Perrin
C Poupon
J-L Martinot
M-L Paillere-Martinot

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/17471288

DOI

10.1038/sj.mp.4002010

ISSN

1359-4184

Ausgabe der Veröffentlichung

11

Zeitschrift

Mol Psychiatry

Schlüsselwörter

Adult
Amygdala
Bipolar Disorder
Brain Mapping
Diffusion Magnetic Resonance Imaging
Female
Gyrus Cinguli
Hippocampus
Humans
Male
Middle Aged
Neural Pathways

Sprache

eng

Country

England

Paginierung

1001 - 1010

PII

4002010

Datum der Veröffentlichung

2007

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2008

Titel

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

12

Datenquelle: PubMed

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

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