Impaired Anatomical Connectivity and Related Executive Functions: Differentiating Vulnerability and Disease Marker in Bipolar Disorder
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Julia Linke
- Andrea V King
- Cyril Poupon
- Michael G Hennerici
- Achim Gass
- Michele Wessa
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000326983900013&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.biopsych.2013.04.010
- eISSN
- 1873-2402
- Externe Identifier
- Clarivate Analytics Document Solution ID: 252DC
- PubMed Identifier: 23684382
- ISSN
- 0006-3223
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- BIOLOGICAL PSYCHIATRY
- Schlüsselwörter
- Bipolar disorder
- DTI
- first-degree relatives
- fractional anisotropy
- risk taking
- set shifting
- Paginierung
- 908 - 916
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Titel
- Impaired Anatomical Connectivity and Related Executive Functions: Differentiating Vulnerability and Disease Marker in Bipolar Disorder
- Sub types
- Article
- Ausgabe der Zeitschrift
- 74
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Julia Linke
- Andrea V King
- Cyril Poupon
- Michael G Hennerici
- Achim Gass
- Michèle Wessa
- DOI
- 10.1016/j.biopsych.2013.04.010
- ISSN
- 0006-3223
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Biological Psychiatry
- Sprache
- en
- Paginierung
- 908 - 916
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.biopsych.2013.04.010
- Datum der Datenerfassung
- 2024
- Titel
- Impaired Anatomical Connectivity and Related Executive Functions: Differentiating Vulnerability and Disease Marker in Bipolar Disorder
- Ausgabe der Zeitschrift
- 74
Datenquelle: Crossref
- Abstract
- <h4>Background</h4>Bipolar 1 disorder (BD1) has been associated with impaired set shifting, increased risk taking, and impaired integrity of frontolimbic white matter. However, it remains unknown to what extent these findings are related to each other and whether these abnormalities represent risk factors or consequences of the illness.<h4>Methods</h4>We addressed the first question by comparing 19 patients with BD1 and 19 healthy control subjects (sample 1) with diffusion tensor imaging, the Intra-Extra Dimensional Set Shift Task, and the Cambridge Gambling Task. The second question we approached by applying the same protocol to 22 healthy first-degree relatives of patients with BD1 and 22 persons without a family history of mental disorders (sample 2).<h4>Results</h4>In comparison with their control groups, BD1 patients and healthy first-degree relatives of patients with BD1 showed significantly reduced fractional anisotropy (FA) in the right anterior limb of the internal capsule and right uncinate fasciculus. White matter integrity in corpus callosum was reduced in BD1 patients only. In addition, reduced FA in anterior limb of the internal capsule correlated significantly with an increased number of errors during set shifting and increased risk taking and reduced FA in uncinate fasciculus correlated significantly with increased risk taking.<h4>Conclusions</h4>Similar white matter alterations in BD1 patients and healthy relatives of BD1 patients are associated with comparable behavioral abnormalities. Further, results indicate that altered frontolimbic and frontothalamic connectivity and corresponding behavioral abnormalities might be a trait and vulnerability marker of BD1, whereas interhemispheric connectivity appears to be a disease marker.
- Addresses
- Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Center of Psychosocial Medicine, Heidelberg University, Heidelberg; Department of Clinical Psychology and Neuropsychology, Psychological Institute, Johannes-Gutenberg University Mainz, Mainz, Germany.
- Autoren
- Julia Linke
- Andrea V King
- Cyril Poupon
- Michael G Hennerici
- Achim Gass
- Michèle Wessa
- DOI
- 10.1016/j.biopsych.2013.04.010
- eISSN
- 1873-2402
- Externe Identifier
- PubMed Identifier: 23684382
- Open access
- false
- ISSN
- 0006-3223
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Biological psychiatry
- Schlüsselwörter
- Brain
- Corpus Callosum
- Nerve Fibers, Myelinated
- Humans
- Diffusion Magnetic Resonance Imaging
- Family
- Cognition Disorders
- Bipolar Disorder
- Psychiatric Status Rating Scales
- Neuropsychological Tests
- Anisotropy
- Adolescent
- Adult
- Middle Aged
- Female
- Male
- Statistics as Topic
- Young Adult
- Executive Function
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2013
- Paginierung
- 908 - 916
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Datum der Datenerfassung
- 2013
- Titel
- Impaired anatomical connectivity and related executive functions: differentiating vulnerability and disease marker in bipolar disorder.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 74
Datenquelle: Europe PubMed Central
- Abstract
- BACKGROUND: Bipolar 1 disorder (BD1) has been associated with impaired set shifting, increased risk taking, and impaired integrity of frontolimbic white matter. However, it remains unknown to what extent these findings are related to each other and whether these abnormalities represent risk factors or consequences of the illness. METHODS: We addressed the first question by comparing 19 patients with BD1 and 19 healthy control subjects (sample 1) with diffusion tensor imaging, the Intra-Extra Dimensional Set Shift Task, and the Cambridge Gambling Task. The second question we approached by applying the same protocol to 22 healthy first-degree relatives of patients with BD1 and 22 persons without a family history of mental disorders (sample 2). RESULTS: In comparison with their control groups, BD1 patients and healthy first-degree relatives of patients with BD1 showed significantly reduced fractional anisotropy (FA) in the right anterior limb of the internal capsule and right uncinate fasciculus. White matter integrity in corpus callosum was reduced in BD1 patients only. In addition, reduced FA in anterior limb of the internal capsule correlated significantly with an increased number of errors during set shifting and increased risk taking and reduced FA in uncinate fasciculus correlated significantly with increased risk taking. CONCLUSIONS: Similar white matter alterations in BD1 patients and healthy relatives of BD1 patients are associated with comparable behavioral abnormalities. Further, results indicate that altered frontolimbic and frontothalamic connectivity and corresponding behavioral abnormalities might be a trait and vulnerability marker of BD1, whereas interhemispheric connectivity appears to be a disease marker.
- Date of acceptance
- 2013
- Autoren
- Julia Linke
- Andrea V King
- Cyril Poupon
- Michael G Hennerici
- Achim Gass
- Michèle Wessa
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/23684382
- DOI
- 10.1016/j.biopsych.2013.04.010
- eISSN
- 1873-2402
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Biol Psychiatry
- Schlüsselwörter
- Bipolar disorder
- DTI
- first-degree relatives
- fractional anisotropy
- risk taking
- set shifting
- Adolescent
- Adult
- Anisotropy
- Bipolar Disorder
- Brain
- Cognition Disorders
- Corpus Callosum
- Diffusion Magnetic Resonance Imaging
- Executive Function
- Family
- Female
- Humans
- Male
- Middle Aged
- Nerve Fibers, Myelinated
- Neuropsychological Tests
- Psychiatric Status Rating Scales
- Statistics as Topic
- Young Adult
- Sprache
- eng
- Country
- United States
- Paginierung
- 908 - 916
- PII
- S0006-3223(13)00356-9
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2014
- Titel
- Impaired anatomical connectivity and related executive functions: differentiating vulnerability and disease marker in bipolar disorder.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 74
Datenquelle: PubMed
- Beziehungen:
- Eigentum von