Enhanced stress analgesia to a cognitively demanding task in patients with posttraumatic stress disorder

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Slawomira J Diener
  • Michele Wessa
  • Stephanie Ridder
  • Simone Lang
  • Martin Diers
  • Regina Steil
  • Herta Flor
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000301996000147&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.jad.2011.06.013
eISSN
1573-2517
Externe Identifier
  • Clarivate Analytics Document Solution ID: 915AT
  • PubMed Identifier: 21733577
ISSN
0165-0327
Ausgabe der Veröffentlichung
3
Zeitschrift
JOURNAL OF AFFECTIVE DISORDERS
Schlüsselwörter
  • PTSD
  • Trauma
  • Pain
  • Analgesia
  • fMRI
  • Stress
Paginierung
1247 - 1251
Datum der Veröffentlichung
2012
Status
Published
Titel
Enhanced stress analgesia to a cognitively demanding task in patients with posttraumatic stress disorder
Sub types
  • Article
Ausgabe der Zeitschrift
136

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • Slawomira J Diener
  • Michèle Wessa
  • Stephanie Ridder
  • Simone Lang
  • Martin Diers
  • Regina Steil
  • Herta Flor
DOI
10.1016/j.jad.2011.06.013
ISSN
0165-0327
Ausgabe der Veröffentlichung
3
Zeitschrift
Journal of Affective Disorders
Sprache
en
Paginierung
1247 - 1251
Datum der Veröffentlichung
2012
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.jad.2011.06.013
Datum der Datenerfassung
2018
Titel
Enhanced stress analgesia to a cognitively demanding task in patients with posttraumatic stress disorder
Ausgabe der Zeitschrift
136

Datenquelle: Crossref

Abstract
<h4>Background</h4>Uncontrollable stress is frequently accompanied by a primarily opioid-mediated stress analgesia. In posttraumatic stress disorder (PTSD) exaggerated stress-induced analgesia to trauma reminders was proposed. The present study investigated whether enhanced analgesia occurs in response to a trauma-unrelated cognitive stressor in PTSD.<h4>Methods</h4>Functional magnetic resonance imaging data were obtained from fourteen outpatients with PTSD and 14 trauma-exposed subjects without PTSD (NPTSD) during mechanical painful stimulation before and after stress. Blood oxygenation level-dependent (BOLD) responses were assessed during painful stimulation. Pain ratings, pain thresholds and pain tolerance were assessed pre- and post-stress. Heart rate and blood pressure were recorded before, during and after stress.<h4>Results</h4>In comparison to NPTSD, PTSD-patients showed significantly more analgesia in terms of an increase of pain threshold and tolerance and a decrease in pain ratings after the stressor. Post-stress, PTSD-patients compared to NPTSD displayed more activation of the rostral anterior cingulate cortex and decreased neural activity in brain areas associated with pain perception. However heart rate increase during stress and blood pressure decrease post-stress was lower in PTSD pointing to a dysregulation of the cardiovascular system in response to stress.<h4>Limitations</h4>The small sample size represents a limiting factor in interpreting the results and might have led to low levels of significance for the group differences in BOLD response changes.<h4>Conclusions</h4>These findings show enhanced stress reactivity and accompanying reduced pain perception in PTSD-patients in contrast to traumatized participants without PTSD. The results suggest that the previously reported enhanced analgesic response after trauma-related stress in PTSD transfers to trauma-unrelated stressors.
Addresses
  • Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Autoren
  • Slawomira J Diener
  • Michèle Wessa
  • Stephanie Ridder
  • Simone Lang
  • Martin Diers
  • Regina Steil
  • Herta Flor
DOI
10.1016/j.jad.2011.06.013
eISSN
1573-2517
Externe Identifier
  • PubMed Identifier: 21733577
Open access
false
ISSN
0165-0327
Ausgabe der Veröffentlichung
3
Zeitschrift
Journal of affective disorders
Schlüsselwörter
  • Brain
  • Humans
  • Pain
  • Magnetic Resonance Imaging
  • Pain Measurement
  • Analgesia
  • Stress, Psychological
  • Pain Threshold
  • Stress Disorders, Post-Traumatic
  • Adult
  • Middle Aged
  • Female
  • Male
  • Pain Perception
Sprache
eng
Medium
Print-Electronic
Online publication date
2011
Paginierung
1247 - 1251
Datum der Veröffentlichung
2012
Status
Published
Datum der Datenerfassung
2011
Titel
Enhanced stress analgesia to a cognitively demanding task in patients with posttraumatic stress disorder.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
136

Datenquelle: Europe PubMed Central

Abstract
BACKGROUND: Uncontrollable stress is frequently accompanied by a primarily opioid-mediated stress analgesia. In posttraumatic stress disorder (PTSD) exaggerated stress-induced analgesia to trauma reminders was proposed. The present study investigated whether enhanced analgesia occurs in response to a trauma-unrelated cognitive stressor in PTSD. METHODS: Functional magnetic resonance imaging data were obtained from fourteen outpatients with PTSD and 14 trauma-exposed subjects without PTSD (NPTSD) during mechanical painful stimulation before and after stress. Blood oxygenation level-dependent (BOLD) responses were assessed during painful stimulation. Pain ratings, pain thresholds and pain tolerance were assessed pre- and post-stress. Heart rate and blood pressure were recorded before, during and after stress. RESULTS: In comparison to NPTSD, PTSD-patients showed significantly more analgesia in terms of an increase of pain threshold and tolerance and a decrease in pain ratings after the stressor. Post-stress, PTSD-patients compared to NPTSD displayed more activation of the rostral anterior cingulate cortex and decreased neural activity in brain areas associated with pain perception. However heart rate increase during stress and blood pressure decrease post-stress was lower in PTSD pointing to a dysregulation of the cardiovascular system in response to stress. LIMITATIONS: The small sample size represents a limiting factor in interpreting the results and might have led to low levels of significance for the group differences in BOLD response changes. CONCLUSIONS: These findings show enhanced stress reactivity and accompanying reduced pain perception in PTSD-patients in contrast to traumatized participants without PTSD. The results suggest that the previously reported enhanced analgesic response after trauma-related stress in PTSD transfers to trauma-unrelated stressors.
Date of acceptance
2011
Autoren
  • Slawomira J Diener
  • Michèle Wessa
  • Stephanie Ridder
  • Simone Lang
  • Martin Diers
  • Regina Steil
  • Herta Flor
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21733577
DOI
10.1016/j.jad.2011.06.013
eISSN
1573-2517
Ausgabe der Veröffentlichung
3
Zeitschrift
J Affect Disord
Schlüsselwörter
  • Adult
  • Analgesia
  • Brain
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Pain
  • Pain Measurement
  • Pain Perception
  • Pain Threshold
  • Stress Disorders, Post-Traumatic
  • Stress, Psychological
Sprache
eng
Country
Netherlands
Paginierung
1247 - 1251
PII
S0165-0327(11)00332-6
Datum der Veröffentlichung
2012
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2012
Titel
Enhanced stress analgesia to a cognitively demanding task in patients with posttraumatic stress disorder.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
136

Datenquelle: PubMed

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