Brain Functional Effects of Psychopharmacological Treatment in Major Depression: A Focus on Neural Circuitry of Affective Processing

Autoren

Michèle Wessa
Giannis Lois

DOI

10.2174/1570159x13666150416224801

ISSN

1570-159X

Ausgabe der Veröffentlichung

4

Zeitschrift

Current Neuropharmacology

Sprache

en

Paginierung

466 - 479

Datum der Veröffentlichung

2015

Status

Published

Herausgeber

Bentham Science Publishers Ltd.

Herausgeber URL

http://dx.doi.org/10.2174/1570159x13666150416224801

Datum der Datenerfassung

2015

Titel

Brain Functional Effects of Psychopharmacological Treatment in Major Depression: a Focus on Neural Circuitry of Affective Processing

Ausgabe der Zeitschrift

13

Datenquelle: Crossref

Abstract

In the last two decades, neuroimaging research has reached a much deeper understanding of the neurobiological underpinnings of major depression (MD) and has converged on functional alterations in limbic and prefrontal neural networks, which are mainly linked to altered emotional processing observed in MD patients. To date, a considerable number of studies have sought to investigate how these neural networks change with pharmacological antidepressant treatment. In the current review, we therefore discuss results from a) pharmacological functional magnetic resonance imaging (fMRI) studies investigating the effects of selective serotonin or noradrenalin reuptake inhibitors on neural activation patterns in relation to emotional processing in healthy individuals, b) treatment studies in patients with unipolar depression assessing changes in neural activation patterns before and after antidepressant pharmacotherapy, and c) predictive neural biomarkers of clinical response in depression. Comparing results from pharmacological fMRI studies in healthy individuals and treatment studies in depressed patients nicely showed parallel findings, mainly for a reduction of limbic activation in response to negative stimuli. A thorough investigation of the empirical findings highlights the importance of the specific paradigm employed in every study which may account for some of the discrepant findings reported in treatment studies in depressed patients.

Addresses

Department of Clinical Psychology and Neuropsychology, Institute for Psychology, Johannes Gutenberg-University Mainz, Wallstraße 3, 55122 Mainz, Germany. wessa@uni-mainz.de.

Autoren

Michèle Wessa
Giannis Lois

DOI

10.2174/1570159x13666150416224801

eISSN

1875-6190

Externe Identifier

PubMed Identifier: 26412066
PubMed Central ID: PMC4790403

Open access

true

ISSN

1570-159X

Ausgabe der Veröffentlichung

4

Zeitschrift

Current neuropharmacology

Schlüsselwörter

Brain
Animals
Humans
Antidepressive Agents
Magnetic Resonance Imaging
Depression
Emotions
Depressive Disorder, Major

Sprache

eng

Medium

Print

Open access status

Open Access

Paginierung

466 - 479

Datum der Veröffentlichung

2015

Status

Published

Publisher licence

CC BY-NC

Datum der Datenerfassung

2015

Titel

Brain Functional Effects of Psychopharmacological Treatment in Major Depression: a Focus on Neural Circuitry of Affective Processing.

Sub types

Research Support, Non-U.S. Gov't
research-article
Review
Journal Article

Ausgabe der Zeitschrift

13

Files

https://europepmc.org/articles/pmc4790403?pdf=render

Datenquelle: Europe PubMed Central

Abstract

In the last two decades, neuroimaging research has reached a much deeper understanding of the neurobiological underpinnings of major depression (MD) and has converged on functional alterations in limbic and prefrontal neural networks, which are mainly linked to altered emotional processing observed in MD patients. To date, a considerable number of studies have sought to investigate how these neural networks change with pharmacological antidepressant treatment. In the current review, we therefore discuss results from a) pharmacological functional magnetic resonance imaging (fMRI) studies investigating the effects of selective serotonin or noradrenalin reuptake inhibitors on neural activation patterns in relation to emotional processing in healthy individuals, b) treatment studies in patients with unipolar depression assessing changes in neural activation patterns before and after antidepressant pharmacotherapy, and c) predictive neural biomarkers of clinical response in depression. Comparing results from pharmacological fMRI studies in healthy individuals and treatment studies in depressed patients nicely showed parallel findings, mainly for a reduction of limbic activation in response to negative stimuli. A thorough investigation of the empirical findings highlights the importance of the specific paradigm employed in every study which may account for some of the discrepant findings reported in treatment studies in depressed patients.

Autoren

Michèle Wessa
Giannis Lois

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/26412066

DOI

10.2174/1570159x13666150416224801

eISSN

1875-6190

Externe Identifier

PubMed Central ID: PMC4790403

Ausgabe der Veröffentlichung

4

Zeitschrift

Curr Neuropharmacol

Schlüsselwörter

Animals
Antidepressive Agents
Brain
Depression
Depressive Disorder, Major
Emotions
Humans
Magnetic Resonance Imaging

Sprache

eng

Country

United Arab Emirates

Paginierung

466 - 479

PII

CN-EPUB-66612

Datum der Veröffentlichung

2015

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2016

Titel

Brain Functional Effects of Psychopharmacological Treatment in Major Depression: a Focus on Neural Circuitry of Affective Processing.

Sub types

Journal Article
Research Support, Non-U.S. Gov't
Review

Ausgabe der Zeitschrift

13

Datenquelle: PubMed

Brain Functional Effects of Psychopharmacological Treatment in Major Depression: A Focus on Neural Circuitry of Affective Processing

Files

Werkzeuge