Neural correlates of valence generalization in an affective conditioning paradigm

Autoren

Anita Schick
Ruth Adam
Barbara Vollmayr
Christine Kuehner
Philipp Kanske
Michèle Wessa

DOI

10.1016/j.bbr.2015.06.009

ISSN

0166-4328

Zeitschrift

Behavioural Brain Research

Sprache

en

Paginierung

147 - 156

Datum der Veröffentlichung

2015

Status

Published

Herausgeber

Elsevier BV

Herausgeber URL

http://dx.doi.org/10.1016/j.bbr.2015.06.009

Datum der Datenerfassung

2019

Titel

Neural correlates of valence generalization in an affective conditioning paradigm

Ausgabe der Zeitschrift

292

Datenquelle: Crossref

Abstract

In case of uncertainty, predictions that are based on prior, similar experiences guide our decision by processes of generalization. Over-generalization of negative information has been identified as an important feature of several psychopathologies, including anxiety disorders and depression, and might underlie biased interpretation of ambiguous information. Here, we investigated the neural correlates of valence generalization to ambiguous stimuli using a translational affective conditioning task during fMRI. Twenty-five healthy individuals participated in a conditioning procedure with (1) an initial acquisition phase, where participants learned the positive and negative valence of two different tones (reference tones) through their responses and subsequent feedback and (2) a test phase, where participants were presented with the previously learned reference tones and three additional tones with intermediate frequency to the learned reference tones. By recording the responses to these intermediate stimuli we were able to assess the participantsí interpretation of ambiguous tones as either positive or negative. Behavioral results revealed a graded response pattern to the three intermediate tones, which was mirrored on the neural level. More specifically, parametric analyses OF BOLD responses to all five tones revealed a linear effect in bilateral anterior insula and SMA with lowest activation to the negative reference tone and highest activation to the positive negative tone. In addition, a cluster in the SMA showed a reverse-quadratic response, i.e., the strongest response for the most ambiguous tone. These findings suggest overlapping regions in the salience network that mediate valence generalization and decision-making under ambiguity, potentially underlying biased ambiguous cue interpretation.

Addresses

Focus Program Translational Neuroscience, Neuroimaging Center Mainz (NIC), Johannes Gutenberg University Medical Center, Mainz, Germany.

Autoren

Anita Schick
Ruth Adam
Barbara Vollmayr
Christine Kuehner
Philipp Kanske
Michèle Wessa

DOI

10.1016/j.bbr.2015.06.009

eISSN

1872-7549

Externe Identifier

PubMed Identifier: 26057359

Open access

false

ISSN

0166-4328

Zeitschrift

Behavioural brain research

Schlüsselwörter

Cerebral Cortex
Humans
Magnetic Resonance Imaging
Acoustic Stimulation
Random Allocation
Cues
Reward
Decision Making
Choice Behavior
Reaction Time
Adult
Female
Male
Bias
Discrimination, Psychological

Sprache

eng

Medium

Print-Electronic

Online publication date

2015

Paginierung

147 - 156

Datum der Veröffentlichung

2015

Status

Published

Datum der Datenerfassung

2015

Titel

Neural correlates of valence generalization in an affective conditioning paradigm.

Sub types

Research Support, Non-U.S. Gov't
Journal Article

Ausgabe der Zeitschrift

292

Datenquelle: Europe PubMed Central

Abstract

In case of uncertainty, predictions that are based on prior, similar experiences guide our decision by processes of generalization. Over-generalization of negative information has been identified as an important feature of several psychopathologies, including anxiety disorders and depression, and might underlie biased interpretation of ambiguous information. Here, we investigated the neural correlates of valence generalization to ambiguous stimuli using a translational affective conditioning task during fMRI. Twenty-five healthy individuals participated in a conditioning procedure with (1) an initial acquisition phase, where participants learned the positive and negative valence of two different tones (reference tones) through their responses and subsequent feedback and (2) a test phase, where participants were presented with the previously learned reference tones and three additional tones with intermediate frequency to the learned reference tones. By recording the responses to these intermediate stimuli we were able to assess the participantsí interpretation of ambiguous tones as either positive or negative. Behavioral results revealed a graded response pattern to the three intermediate tones, which was mirrored on the neural level. More specifically, parametric analyses OF BOLD responses to all five tones revealed a linear effect in bilateral anterior insula and SMA with lowest activation to the negative reference tone and highest activation to the positive negative tone. In addition, a cluster in the SMA showed a reverse-quadratic response, i.e., the strongest response for the most ambiguous tone. These findings suggest overlapping regions in the salience network that mediate valence generalization and decision-making under ambiguity, potentially underlying biased ambiguous cue interpretation.

Date of acceptance

2015

Autoren

Anita Schick
Ruth Adam
Barbara Vollmayr
Christine Kuehner
Philipp Kanske
Michèle Wessa

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/26057359

DOI

10.1016/j.bbr.2015.06.009

eISSN

1872-7549

Zeitschrift

Behav Brain Res

Schlüsselwörter

Auditory discrimination
Cognitive bias
Salience
Uncertainty
fMRI
Acoustic Stimulation
Adult
Bias
Cerebral Cortex
Choice Behavior
Cues
Decision Making
Discrimination, Psychological
Female
Humans
Magnetic Resonance Imaging
Male
Random Allocation
Reaction Time
Reward

Sprache

eng

Country

Netherlands

Paginierung

147 - 156

PII

S0166-4328(15)30036-X

Datum der Veröffentlichung

2015

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2016

Titel

Neural correlates of valence generalization in an affective conditioning paradigm.

Sub types

Journal Article
Research Support, Non-U.S. Gov't

Ausgabe der Zeitschrift

292

Datenquelle: PubMed

Neural correlates of valence generalization in an affective conditioning paradigm

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