Indirect assessment of an interpretation bias in humans: neurophysiological and behavioral correlates
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Anita Schick
- Michele Wessa
- Barbara Vollmayr
- Christine Kuehner
- Philipp Kanske
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000320227900001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3389/fnhum.2013.00272
- Externe Identifier
- Clarivate Analytics Document Solution ID: 161XU
- PubMed Identifier: 23781193
- ISSN
- 1662-5161
- Zeitschrift
- FRONTIERS IN HUMAN NEUROSCIENCE
- Schlüsselwörter
- ERP
- N200
- LPP
- cognitive bias
- rumination
- reflective pondering
- Artikelnummer
- ARTN 272
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Titel
- Indirect assessment of an interpretation bias in humans: neurophysiological and behavioral correlates
- Sub types
- Article
- Ausgabe der Zeitschrift
- 7
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Anita Schick
- Michèle Wessa
- Barbara Vollmayr
- Christine Kuehner
- Philipp Kanske
- DOI
- 10.3389/fnhum.2013.00272
- eISSN
- 1662-5161
- Zeitschrift
- Frontiers in Human Neuroscience
- Online publication date
- 2013
- Status
- Published online
- Herausgeber
- Frontiers Media SA
- Herausgeber URL
- http://dx.doi.org/10.3389/fnhum.2013.00272
- Datum der Datenerfassung
- 2015
- Titel
- Indirect assessment of an interpretation bias in humans: neurophysiological and behavioral correlates
- Ausgabe der Zeitschrift
- 7
Datenquelle: Crossref
- Abstract
- Affective state can influence cognition leading to biased information processing, interpretation, attention, and memory. Such bias has been reported to be essential for the onset and maintenance of different psychopathologies, particularly affective disorders. However, empirical evidence has been very heterogeneous and little is known about the neurophysiological mechanisms underlying cognitive bias and its time-course. We therefore investigated the interpretation of ambiguous stimuli as indicators of biased information processing with an ambiguous cue-conditioning paradigm. In an acquisition phase, participants learned to discriminate two tones of different frequency, which acquired emotional and motivational value due to subsequent feedback (monetary gain or avoidance of monetary loss). In the test phase, three additional tones of intermediate frequencies were presented, whose interpretation as positive (approach of reward) or negative (avoidance of punishment), indicated by a button press, was used as an indicator of the bias. Twenty healthy volunteers participated in this paradigm while a 64-channel electroencephalogram was recorded. Participants also completed questionnaires assessing individual differences in depression and rumination. Overall, we found a small positive bias, which correlated negatively with reflective pondering, a type of rumination. As expected, reaction times were increased for intermediate tones. ERP amplitudes between 300 and 700 ms post-stimulus differed depending on the interpretation of the intermediate tones. A negative compared to a positive interpretation led to an amplitude increase over frontal electrodes. Our study provides evidence that in humans, as in animal research, the ambiguous cue-conditioning paradigm is a valid procedure for indirectly assessing ambiguous cue interpretation and a potential interpretation bias, which is sensitive to individual differences in affect-related traits.
- Addresses
- Department of General Psychiatry, Section for Experimental Psychopathology and Neuroimaging, Center for Psychosocial Medicine, Heidelberg University Heidelberg, Germany.
- Autoren
- Anita Schick
- Michèle Wessa
- Barbara Vollmayr
- Christine Kuehner
- Philipp Kanske
- DOI
- 10.3389/fnhum.2013.00272
- eISSN
- 1662-5161
- Externe Identifier
- PubMed Identifier: 23781193
- PubMed Central ID: PMC3679614
- Open access
- true
- ISSN
- 1662-5161
- Zeitschrift
- Frontiers in human neuroscience
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2013
- Open access status
- Open Access
- Paginierung
- 272
- Datum der Veröffentlichung
- 2013
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2013
- Titel
- Indirect assessment of an interpretation bias in humans: neurophysiological and behavioral correlates.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 7
Files
https://www.frontiersin.org/articles/10.3389/fnhum.2013.00272/pdf https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23781193/pdf/?tool=EBI https://europepmc.org/articles/PMC3679614?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Affective state can influence cognition leading to biased information processing, interpretation, attention, and memory. Such bias has been reported to be essential for the onset and maintenance of different psychopathologies, particularly affective disorders. However, empirical evidence has been very heterogeneous and little is known about the neurophysiological mechanisms underlying cognitive bias and its time-course. We therefore investigated the interpretation of ambiguous stimuli as indicators of biased information processing with an ambiguous cue-conditioning paradigm. In an acquisition phase, participants learned to discriminate two tones of different frequency, which acquired emotional and motivational value due to subsequent feedback (monetary gain or avoidance of monetary loss). In the test phase, three additional tones of intermediate frequencies were presented, whose interpretation as positive (approach of reward) or negative (avoidance of punishment), indicated by a button press, was used as an indicator of the bias. Twenty healthy volunteers participated in this paradigm while a 64-channel electroencephalogram was recorded. Participants also completed questionnaires assessing individual differences in depression and rumination. Overall, we found a small positive bias, which correlated negatively with reflective pondering, a type of rumination. As expected, reaction times were increased for intermediate tones. ERP amplitudes between 300 and 700 ms post-stimulus differed depending on the interpretation of the intermediate tones. A negative compared to a positive interpretation led to an amplitude increase over frontal electrodes. Our study provides evidence that in humans, as in animal research, the ambiguous cue-conditioning paradigm is a valid procedure for indirectly assessing ambiguous cue interpretation and a potential interpretation bias, which is sensitive to individual differences in affect-related traits.
- Date of acceptance
- 2013
- Autoren
- Anita Schick
- Michèle Wessa
- Barbara Vollmayr
- Christine Kuehner
- Philipp Kanske
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/23781193
- DOI
- 10.3389/fnhum.2013.00272
- Externe Identifier
- PubMed Central ID: PMC3679614
- ISSN
- 1662-5161
- Zeitschrift
- Front Hum Neurosci
- Schlüsselwörter
- ERP
- LPP
- N200
- cognitive bias
- reflective pondering
- rumination
- Sprache
- eng
- Country
- Switzerland
- Paginierung
- 272
- Datum der Veröffentlichung
- 2013
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2013
- Titel
- Indirect assessment of an interpretation bias in humans: neurophysiological and behavioral correlates.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 7
Datenquelle: PubMed
- Beziehungen:
- Eigentum von