Large-scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Giannis Lois
  • Martin F Gerchen
  • Peter Kirsch
  • Philipp Kanske
  • Sandra Schoenfelder
  • Michele Wessa
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000413569800010&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1111/bdi.12512
eISSN
1399-5618
Externe Identifier
  • Clarivate Analytics Document Solution ID: FK5VJ
  • PubMed Identifier: 28960669
ISSN
1398-5647
Ausgabe der Veröffentlichung
6
Zeitschrift
BIPOLAR DISORDERS
Schlüsselwörter
  • bipolar disorder
  • default mode network
  • depression
  • functional connectivity
  • large-scale networks
Paginierung
487 - 495
Datum der Veröffentlichung
2017
Status
Published
Titel
Large-scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients
Sub types
  • Article
Ausgabe der Zeitschrift
19

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:sec><jats:title>Objectives</jats:title><jats:p>The human brain is organized into large‐scale networks that dynamically interact with each other. Extensive evidence has shown characteristic changes in certain large‐scale networks during transitions from internally directed to externally directed attention. The aim of the present study was to compare these context‐dependent network interactions during emotion regulation and to examine potential alterations in remitted unipolar and bipolar disorder patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We employed a multi‐region generalized psychophysiological interactions analysis to quantify connectivity changes during distraction vs reappraisal pair‐wise across 90 regions placed throughout the four networks of interest (default‐mode, frontoparietal, salience, and dorsal attention networks). Using network contingency analysis and permutation testing, we estimated the likelihood that the number of significant condition‐dependent connectivity changes in every pair of networks exceeds the number expected by chance. We first examined the pattern of functional connectivity in 42 healthy subjects (sample I) and then compared these connectivity patterns across healthy individuals (n=23) and remitted bipolar (n=21) and unipolar disorder patients (n=21) in an independent sample <jats:styled-content style="fixed-case">II</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In sample I, distraction compared to reappraisal was characterized by reduced connectivity within the default‐mode network and between the default‐mode and two cognitive control networks and increased connectivity among the cognitive control networks. In sample <jats:styled-content style="fixed-case">II</jats:styled-content>, both patient groups exhibited abnormally increased default‐mode intra‐ and inter‐network connectivity during distraction compared to reappraisal.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The present study highlights the role of large‐scale network interactions in emotion regulation and provides preliminary evidence of default‐mode inter‐ and intra‐network connectivity impairments in remitted bipolar and unipolar patients during emotion regulation.</jats:p></jats:sec>
Autoren
  • Giannis Lois
  • Martin F Gerchen
  • Peter Kirsch
  • Philipp Kanske
  • Sandra Schönfelder
  • Michèle Wessa
DOI
10.1111/bdi.12512
eISSN
1399-5618
ISSN
1398-5647
Ausgabe der Veröffentlichung
6
Zeitschrift
Bipolar Disorders
Sprache
en
Online publication date
2017
Paginierung
487 - 495
Datum der Veröffentlichung
2017
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1111/bdi.12512
Datum der Datenerfassung
2023
Titel
Large‐scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients
Ausgabe der Zeitschrift
19

Datenquelle: Crossref

Abstract
<h4>Objectives</h4>The human brain is organized into large-scale networks that dynamically interact with each other. Extensive evidence has shown characteristic changes in certain large-scale networks during transitions from internally directed to externally directed attention. The aim of the present study was to compare these context-dependent network interactions during emotion regulation and to examine potential alterations in remitted unipolar and bipolar disorder patients.<h4>Methods</h4>We employed a multi-region generalized psychophysiological interactions analysis to quantify connectivity changes during distraction vs reappraisal pair-wise across 90 regions placed throughout the four networks of interest (default-mode, frontoparietal, salience, and dorsal attention networks). Using network contingency analysis and permutation testing, we estimated the likelihood that the number of significant condition-dependent connectivity changes in every pair of networks exceeds the number expected by chance. We first examined the pattern of functional connectivity in 42 healthy subjects (sample I) and then compared these connectivity patterns across healthy individuals (n=23) and remitted bipolar (n=21) and unipolar disorder patients (n=21) in an independent sample II.<h4>Results</h4>In sample I, distraction compared to reappraisal was characterized by reduced connectivity within the default-mode network and between the default-mode and two cognitive control networks and increased connectivity among the cognitive control networks. In sample II, both patient groups exhibited abnormally increased default-mode intra- and inter-network connectivity during distraction compared to reappraisal.<h4>Conclusions</h4>The present study highlights the role of large-scale network interactions in emotion regulation and provides preliminary evidence of default-mode inter- and intra-network connectivity impairments in remitted bipolar and unipolar patients during emotion regulation.
Addresses
  • Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Johannes Gutenberg-University Mainz, Mainz, Germany.
Autoren
  • Giannis Lois
  • Martin F Gerchen
  • Peter Kirsch
  • Philipp Kanske
  • Sandra Schönfelder
  • Michèle Wessa
DOI
10.1111/bdi.12512
eISSN
1399-5618
Externe Identifier
  • PubMed Identifier: 28960669
Funding acknowledgements
  • Bundesministerium für Bildung und Forschung: 01GQ1003B
  • Deutsche Forschungsgemeinschaft: We3638/3‐1
Open access
false
ISSN
1398-5647
Ausgabe der Veröffentlichung
6
Zeitschrift
Bipolar disorders
Schlüsselwörter
  • Brain
  • Nerve Net
  • Humans
  • Emotions
  • Cognition
  • Attention
  • Bipolar Disorder
  • Neuronal Plasticity
  • Adult
  • Female
  • Male
  • Connectome
Sprache
eng
Medium
Print-Electronic
Online publication date
2017
Paginierung
487 - 495
Datum der Veröffentlichung
2017
Status
Published
Datum der Datenerfassung
2017
Titel
Large-scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
19

Datenquelle: Europe PubMed Central

Abstract
OBJECTIVES: The human brain is organized into large-scale networks that dynamically interact with each other. Extensive evidence has shown characteristic changes in certain large-scale networks during transitions from internally directed to externally directed attention. The aim of the present study was to compare these context-dependent network interactions during emotion regulation and to examine potential alterations in remitted unipolar and bipolar disorder patients. METHODS: We employed a multi-region generalized psychophysiological interactions analysis to quantify connectivity changes during distraction vs reappraisal pair-wise across 90 regions placed throughout the four networks of interest (default-mode, frontoparietal, salience, and dorsal attention networks). Using network contingency analysis and permutation testing, we estimated the likelihood that the number of significant condition-dependent connectivity changes in every pair of networks exceeds the number expected by chance. We first examined the pattern of functional connectivity in 42 healthy subjects (sample I) and then compared these connectivity patterns across healthy individuals (n=23) and remitted bipolar (n=21) and unipolar disorder patients (n=21) in an independent sample II. RESULTS: In sample I, distraction compared to reappraisal was characterized by reduced connectivity within the default-mode network and between the default-mode and two cognitive control networks and increased connectivity among the cognitive control networks. In sample II, both patient groups exhibited abnormally increased default-mode intra- and inter-network connectivity during distraction compared to reappraisal. CONCLUSIONS: The present study highlights the role of large-scale network interactions in emotion regulation and provides preliminary evidence of default-mode inter- and intra-network connectivity impairments in remitted bipolar and unipolar patients during emotion regulation.
Date of acceptance
2017
Autoren
  • Giannis Lois
  • Martin F Gerchen
  • Peter Kirsch
  • Philipp Kanske
  • Sandra Schönfelder
  • Michèle Wessa
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/28960669
DOI
10.1111/bdi.12512
eISSN
1399-5618
Ausgabe der Veröffentlichung
6
Zeitschrift
Bipolar Disord
Schlüsselwörter
  • bipolar disorder
  • default mode network
  • depression
  • functional connectivity
  • large-scale networks
  • Adult
  • Attention
  • Bipolar Disorder
  • Brain
  • Cognition
  • Connectome
  • Emotions
  • Female
  • Humans
  • Male
  • Nerve Net
  • Neuronal Plasticity
Sprache
eng
Country
Denmark
Paginierung
487 - 495
Datum der Veröffentlichung
2017
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2018
Titel
Large-scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
19

Datenquelle: PubMed

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