Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Matthias Krumb
  • Marie-Luise Frey
  • Jens Langhanki
  • Robert Forster
  • Danuta Kowalczyk
  • Volker Mailander
  • Katharina Landfester
  • Till Opatz
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000582037400001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3390/cells9092087
eISSN
2073-4409
Externe Identifier
  • Clarivate Analytics Document Solution ID: OG7CL
  • PubMed Identifier: 32932639
Ausgabe der Veröffentlichung
9
Zeitschrift
CELLS
Schlüsselwörter
  • carbohydrates
  • glycodendrons
  • dendritic cells
  • nanocapsules
  • cell targeting
Artikelnummer
ARTN 2087
Datum der Veröffentlichung
2020
Status
Published
Titel
Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells
Sub types
  • Article
Ausgabe der Zeitschrift
9

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:p>Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used.</jats:p>
Autoren
  • Matthias Krumb
  • Marie-Luise Frey
  • Jens Langhanki
  • Robert Forster
  • Danuta Kowalczyk
  • Volker Mailänder
  • Katharina Landfester
  • Till Opatz
DOI
10.3390/cells9092087
eISSN
2073-4409
Ausgabe der Veröffentlichung
9
Zeitschrift
Cells
Sprache
en
Online publication date
2020
Paginierung
2087 - 2087
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/cells9092087
Datum der Datenerfassung
2020
Titel
Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells
Ausgabe der Zeitschrift
9

Datenquelle: Crossref

Abstract
Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used.
Addresses
  • Department of Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
Autoren
  • Matthias Krumb
  • Marie-Luise Frey
  • Jens Langhanki
  • Robert Forster
  • Danuta Kowalczyk
  • Volker Mailänder
  • Katharina Landfester
  • Till Opatz
DOI
10.3390/cells9092087
eISSN
2073-4409
Externe Identifier
  • PubMed Identifier: 32932639
  • PubMed Central ID: PMC7564404
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft: SFB1066-2
Open access
true
ISSN
2073-4409
Ausgabe der Veröffentlichung
9
Zeitschrift
Cells
Schlüsselwörter
  • Dendritic Cells
  • Cells, Cultured
  • Humans
  • Carbohydrates
  • Ligands
  • Drug Delivery Systems
  • Biological Transport
  • Blood Donors
  • Nanocapsules
  • Hydroxyethyl Starch Derivatives
Sprache
eng
Medium
Electronic
Online publication date
2020
Open access status
Open Access
Paginierung
E2087
Datum der Veröffentlichung
2020
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2020
Titel
Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
9

Files

https://www.mdpi.com/2073-4409/9/9/2087/pdf?version=1599901878 https://europepmc.org/articles/PMC7564404?pdf=render

Datenquelle: Europe PubMed Central

Abstract
Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used.
Date of acceptance
2020
Autoren
  • Matthias Krumb
  • Marie-Luise Frey
  • Jens Langhanki
  • Robert Forster
  • Danuta Kowalczyk
  • Volker Mailänder
  • Katharina Landfester
  • Till Opatz
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/32932639
DOI
10.3390/cells9092087
eISSN
2073-4409
Externe Identifier
  • PubMed Central ID: PMC7564404
Ausgabe der Veröffentlichung
9
Zeitschrift
Cells
Schlüsselwörter
  • carbohydrates
  • cell targeting
  • dendritic cells
  • glycodendrons
  • nanocapsules
  • Biological Transport
  • Blood Donors
  • Carbohydrates
  • Cells, Cultured
  • Dendritic Cells
  • Drug Delivery Systems
  • Humans
  • Hydroxyethyl Starch Derivatives
  • Ligands
  • Nanocapsules
Sprache
eng
Country
Switzerland
PII
cells9092087
Datum der Veröffentlichung
2020
Status
Published online
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
9

Datenquelle: PubMed

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