A concise route to MK-4482 (EIDD-2801) from cytidine
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- N Vasudevan
- Grace P Ahlqvist
- Catherine P McGeough
- Dinesh J Paymode
- Flavio SP Cardoso
- Tobias Lucas
- Jule-Phillip Dietz
- Till Opatz
- Timothy F Jamison
- Frank B Gupton
- David R Snead
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000584203400012&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1039/d0cc05944g
- eISSN
- 1364-548X
- Externe Identifier
- Clarivate Analytics Document Solution ID: OJ8KR
- PubMed Identifier: 33030468
- ISSN
- 1359-7345
- Ausgabe der Veröffentlichung
- 87
- Zeitschrift
- CHEMICAL COMMUNICATIONS
- Paginierung
- 13363 - 13364
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Titel
- A concise route to MK-4482 (EIDD-2801) from cytidine
- Sub types
- Article
- Ausgabe der Zeitschrift
- 56
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <p>A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine.</p>
- Autoren
- N Vasudevan
- Grace P Ahlqvist
- Catherine P McGeough
- Dinesh J Paymode
- Flavio SP Cardoso
- Tobias Lucas
- Jule-Phillip Dietz
- Till Opatz
- Timothy F Jamison
- Frank B Gupton
- David R Snead
- DOI
- 10.1039/d0cc05944g
- eISSN
- 1364-548X
- ISSN
- 1359-7345
- Ausgabe der Veröffentlichung
- 87
- Zeitschrift
- Chemical Communications
- Sprache
- en
- Online publication date
- 2020
- Paginierung
- 13363 - 13364
- Status
- Published online
- Herausgeber
- Royal Society of Chemistry (RSC)
- Herausgeber URL
- http://dx.doi.org/10.1039/d0cc05944g
- Datum der Datenerfassung
- 2024
- Titel
- A concise route to MK-4482 (EIDD-2801) from cytidine
- Ausgabe der Zeitschrift
- 56
Datenquelle: Crossref
- Abstract
- A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine. The selective acylation and direct amination eliminate the need for protecting and activating groups and proceed in overall yield of 75%, a significant advancement over the reported yield of 17%. The step count is reduced from five transformations to two, and expensive uridine is replaced with the more available cytidine.
- Addresses
- Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond, VA 23298-0100, USA. drsnead@vcu.edu.
- Autoren
- N Vasudevan
- Grace P Ahlqvist
- Catherine P McGeough
- Dinesh J Paymode
- Flavio SP Cardoso
- Tobias Lucas
- Jule-Phillip Dietz
- Till Opatz
- Timothy F Jamison
- Frank B Gupton
- David R Snead
- DOI
- 10.1039/d0cc05944g
- eISSN
- 1364-548X
- Externe Identifier
- PubMed Identifier: 33030468
- Funding acknowledgements
- National Science Foundation: 1745302
- Bill and Melinda Gates Foundation: OPP1176590
- Open access
- false
- ISSN
- 1359-7345
- Ausgabe der Veröffentlichung
- 87
- Zeitschrift
- Chemical communications (Cambridge, England)
- Schlüsselwörter
- Hydroxylamines
- Cytidine
- Acylation
- Kinetics
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2020
- Paginierung
- 13363 - 13364
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Publisher licence
- CC BY-NC
- Datum der Datenerfassung
- 2020
- Titel
- A concise route to MK-4482 (EIDD-2801) from cytidine.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 56
Datenquelle: Europe PubMed Central
- Abstract
- A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine. The selective acylation and direct amination eliminate the need for protecting and activating groups and proceed in overall yield of 75%, a significant advancement over the reported yield of 17%. The step count is reduced from five transformations to two, and expensive uridine is replaced with the more available cytidine.
- Autoren
- N Vasudevan
- Grace P Ahlqvist
- Catherine P McGeough
- Dinesh J Paymode
- Flavio SP Cardoso
- Tobias Lucas
- Jule-Phillip Dietz
- Till Opatz
- Timothy F Jamison
- Frank B Gupton
- David R Snead
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/33030468
- DOI
- 10.1039/d0cc05944g
- eISSN
- 1364-548X
- Ausgabe der Veröffentlichung
- 87
- Zeitschrift
- Chem Commun (Camb)
- Schlüsselwörter
- Acylation
- Cytidine
- Hydroxylamines
- Kinetics
- Sprache
- eng
- Country
- England
- Paginierung
- 13363 - 13364
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Titel
- A concise route to MK-4482 (EIDD-2801) from cytidine.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 56
Datenquelle: PubMed
- Beziehungen:
- Eigentum von