Myristic Acid Inhibits the Activity of the Bacterial ABC Transporter BmrA
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Kristin Oepen
- Hueseyin Ozbek
- Anja Schueffler
- Johannes C Liermann
- Eckhard Thines
- Dirk Schneider
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000738289800001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/ijms222413565
- eISSN
- 1422-0067
- Externe Identifier
- Clarivate Analytics Document Solution ID: YA4EZ
- PubMed Identifier: 34948362
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Schlüsselwörter
- ABC transporter
- BmrA
- membrane transport
- myristic acid
- inhibitor
- Artikelnummer
- ARTN 13565
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- Myristic Acid Inhibits the Activity of the Bacterial ABC Transporter BmrA
- Sub types
- Article
- Ausgabe der Zeitschrift
- 22
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>ATP-binding cassette (ABC) transporters are conserved in all kingdoms of life, where they transport substrates against a concentration gradient across membranes. Some ABC transporters are known to cause multidrug resistances in humans and are able to transport chemotherapeutics across cellular membranes. Similarly, BmrA, the ABC transporter of Bacillus subtilis, is involved in excretion of certain antibiotics out of bacterial cells. Screening of extract libraries isolated from fungi revealed that the C14 fatty acid myristic acid has an inhibitory effect on the BmrA ATPase as well as the transport activity. Thus, a natural membrane constituent inhibits the BmrA activity, a finding with physiological consequences as to the activity and regulation of ABC transporter activities in biological membranes.</jats:p>
- Autoren
- Kristin Oepen
- Hüseyin Özbek
- Anja Schüffler
- Johannes C Liermann
- Eckhard Thines
- Dirk Schneider
- DOI
- 10.3390/ijms222413565
- eISSN
- 1422-0067
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- International Journal of Molecular Sciences
- Sprache
- en
- Online publication date
- 2021
- Paginierung
- 13565 - 13565
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/ijms222413565
- Datum der Datenerfassung
- 2021
- Titel
- Myristic Acid Inhibits the Activity of the Bacterial ABC Transporter BmrA
- Ausgabe der Zeitschrift
- 22
Datenquelle: Crossref
- Abstract
- ATP-binding cassette (ABC) transporters are conserved in all kingdoms of life, where they transport substrates against a concentration gradient across membranes. Some ABC transporters are known to cause multidrug resistances in humans and are able to transport chemotherapeutics across cellular membranes. Similarly, BmrA, the ABC transporter of <i>Bacillus subtilis,</i> is involved in excretion of certain antibiotics out of bacterial cells. Screening of extract libraries isolated from fungi revealed that the C14 fatty acid myristic acid has an inhibitory effect on the BmrA ATPase as well as the transport activity. Thus, a natural membrane constituent inhibits the BmrA activity, a finding with physiological consequences as to the activity and regulation of ABC transporter activities in biological membranes.
- Addresses
- Department of Chemistry, Johannes Gutenberg-University, 55128 Mainz, Germany.
- Autoren
- Kristin Oepen
- Hüseyin Özbek
- Anja Schüffler
- Johannes C Liermann
- Eckhard Thines
- Dirk Schneider
- DOI
- 10.3390/ijms222413565
- eISSN
- 1422-0067
- Externe Identifier
- PubMed Identifier: 34948362
- PubMed Central ID: PMC8707315
- Funding acknowledgements
- Naturwissenschaftlich-Medizinisches Forschungszentrum (NMFZ) Mainz: N/A
- DynaMem (State of Rhineland-Palatinate): N/A
- Open access
- true
- ISSN
- 1422-0067
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- International journal of molecular sciences
- Schlüsselwörter
- Bacillus subtilis
- Myristic Acid
- Bacterial Proteins
- ATP-Binding Cassette Transporters
- Adenosine Triphosphatases
- Drug Discovery
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2021
- Open access status
- Open Access
- Paginierung
- 13565
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2021
- Titel
- Myristic Acid Inhibits the Activity of the Bacterial ABC Transporter BmrA.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 22
Files
https://www.mdpi.com/1422-0067/22/24/13565/pdf?version=1639977127 https://europepmc.org/articles/PMC8707315?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- ATP-binding cassette (ABC) transporters are conserved in all kingdoms of life, where they transport substrates against a concentration gradient across membranes. Some ABC transporters are known to cause multidrug resistances in humans and are able to transport chemotherapeutics across cellular membranes. Similarly, BmrA, the ABC transporter of Bacillus subtilis, is involved in excretion of certain antibiotics out of bacterial cells. Screening of extract libraries isolated from fungi revealed that the C14 fatty acid myristic acid has an inhibitory effect on the BmrA ATPase as well as the transport activity. Thus, a natural membrane constituent inhibits the BmrA activity, a finding with physiological consequences as to the activity and regulation of ABC transporter activities in biological membranes.
- Date of acceptance
- 2021
- Autoren
- Kristin Oepen
- Hüseyin Özbek
- Anja Schüffler
- Johannes C Liermann
- Eckhard Thines
- Dirk Schneider
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/34948362
- DOI
- 10.3390/ijms222413565
- eISSN
- 1422-0067
- Externe Identifier
- PubMed Central ID: PMC8707315
- Funding acknowledgements
- Naturwissenschaftlich-Medizinisches Forschungszentrum (NMFZ) Mainz: N/A
- DynaMem (State of Rhineland-Palatinate): N/A
- Ausgabe der Veröffentlichung
- 24
- Zeitschrift
- Int J Mol Sci
- Schlüsselwörter
- ABC transporter
- BmrA
- inhibitor
- membrane transport
- myristic acid
- ATP-Binding Cassette Transporters
- Adenosine Triphosphatases
- Bacillus subtilis
- Bacterial Proteins
- Drug Discovery
- Myristic Acid
- Sprache
- eng
- Country
- Switzerland
- PII
- ijms222413565
- Datum der Veröffentlichung
- 2021
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Myristic Acid Inhibits the Activity of the Bacterial ABC Transporter BmrA.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 22
Datenquelle: PubMed
- Beziehungen:
- Eigentum von