Insights into the In Vitro Formation of Apatite from Mg-Stabilized Amorphous Calcium Carbonate

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Phil Opitz
  • Laura Besch
  • Martin Panthoefer
  • Anke Kabelitz
  • Ronald E Unger
  • Franziska Emmerling
  • Mihail Mondeshki
  • Wolfgang Tremel
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000587980500001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/adfm.202007830
eISSN
1616-3028
Externe Identifier
  • Clarivate Analytics Document Solution ID: PV2HF
ISSN
1616-301X
Ausgabe der Veröffentlichung
3
Zeitschrift
ADVANCED FUNCTIONAL MATERIALS
Schlüsselwörter
  • calcium carbonate
  • calcium phosphate
  • amorphous
  • apatite
  • phase transformation
Artikelnummer
ARTN 2007830
Datum der Veröffentlichung
2021
Status
Published
Titel
Insights into the In Vitro Formation of Apatite from Mg-Stabilized Amorphous Calcium Carbonate
Sub types
  • Article
Ausgabe der Zeitschrift
31

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:title>Abstract</jats:title><jats:p>A protein‐free formation of bone‐like apatite from amorphous precursors through ball‐milling is reported. Mg<jats:sup>2+</jats:sup> ions are crucial to achieve full amorphization of CaCO<jats:sub>3</jats:sub>. Mg<jats:sup>2+</jats:sup> incorporation generates defects which strongly retard a recrystallization of ball‐milled Mg‐doped amorphous calcium carbonate (BM‐aMCC), which promotes the growth of osteoblastic and endothelial cells in simulated body fluid and has no effect on endothelial cell gene expression. Ex situ snapshots of the processes revealed the reaction mechanisms. For low Mg contents (&lt;30%) a two phase system consisting of Mg‐doped amorphous calcium carbonate (ACC) and calcite “impurities” was formed. For high (&gt;40%) Mg<jats:sup>2+</jats:sup> contents, BM‐aMCC follows a different crystallization path via magnesian calcite and monohydrocalcite to aragonite. While pure ACC crystallizes rapidly to calcite in aqueous media, Mg‐doped ACC forms in the presence of phosphate ions bone‐like hydroxycarbonate apatite (dahllite), a carbonate apatite with carbonate substitution in both type A (OH<jats:sup>−</jats:sup>) and type B (PO<jats:sub>4</jats:sub><jats:sup>3−</jats:sup>) sites, which grows on calcite “impurities” via heterogeneous nucleation. This process produces an endotoxin‐free material and makes BM‐aMCC an excellent “ion storage buffer” that promotes cell growth by stimulating cell viability and metabolism with promising applications in the treatment of bone defects and bone degenerative diseases.</jats:p>
Autoren
  • Phil Opitz
  • Laura Besch
  • Martin Panthöfer
  • Anke Kabelitz
  • Ronald E Unger
  • Franziska Emmerling
  • Mihail Mondeshki
  • Wolfgang Tremel
DOI
10.1002/adfm.202007830
eISSN
1616-3028
ISSN
1616-301X
Ausgabe der Veröffentlichung
3
Zeitschrift
Advanced Functional Materials
Sprache
en
Online publication date
2020
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/adfm.202007830
Datum der Datenerfassung
2023
Titel
Insights into the In Vitro Formation of Apatite from Mg‐Stabilized Amorphous Calcium Carbonate
Ausgabe der Zeitschrift
31

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