Synthesis, X-ray Structure Determination, and Comprehensive Photochemical Characterization of (Trifluoromethyl) diazirine-Containing TRPML1 Ligands
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Kevin Schwickert
- Michal Andrzejewski
- Simon Grabowsky
- Tanja Schirmeister
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000649101400013&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1021/acs.joc.0c02993
- eISSN
- 1520-6904
- Externe Identifier
- Clarivate Analytics Document Solution ID: SA2AB
- PubMed Identifier: 33835801
- ISSN
- 0022-3263
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- JOURNAL OF ORGANIC CHEMISTRY
- Paginierung
- 6169 - 6183
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- Synthesis, X-ray Structure Determination, and Comprehensive Photochemical Characterization of (Trifluoromethyl)diazirine-Containing TRPML1 Ligands
- Sub types
- Article
- Ausgabe der Zeitschrift
- 86
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Kevin Schwickert
- Michał Andrzejewski
- Simon Grabowsky
- Tanja Schirmeister
- DOI
- 10.1021/acs.joc.0c02993
- eISSN
- 1520-6904
- ISSN
- 0022-3263
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- The Journal of Organic Chemistry
- Sprache
- en
- Online publication date
- 2021
- Paginierung
- 6169 - 6183
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Herausgeber
- American Chemical Society (ACS)
- Herausgeber URL
- http://dx.doi.org/10.1021/acs.joc.0c02993
- Datum der Datenerfassung
- 2023
- Titel
- Synthesis, X-ray Structure Determination, and Comprehensive Photochemical Characterization of (Trifluoromethyl)diazirine-Containing TRPML1 Ligands
- Ausgabe der Zeitschrift
- 86
Datenquelle: Crossref
- Abstract
- Potential (trifluoromethyl)diazirine-based TRPML1 ion channel ligands were designed and synthesized, and their structures were determined by single-crystal X-ray diffraction analysis. Photoactivation studies via <sup>19</sup>F NMR spectroscopy and HPLC-MS analysis revealed distinct kinetical characteristics in selected solvents and favorable photochemical properties in an aqueous buffer. These photoactivatable TRPML activators represent useful and valuable tools for TRPML photoaffinity labeling combined with mass spectrometry.
- Addresses
- Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, 55128 Mainz, Germany.
- Autoren
- Kevin Schwickert
- Michał Andrzejewski
- Simon Grabowsky
- Tanja Schirmeister
- DOI
- 10.1021/acs.joc.0c02993
- eISSN
- 1520-6904
- Externe Identifier
- PubMed Identifier: 33835801
- Open access
- false
- ISSN
- 0022-3263
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- The Journal of organic chemistry
- Schlüsselwörter
- Diazomethane
- Photoaffinity Labels
- Ligands
- X-Rays
- Mass Spectrometry
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2021
- Paginierung
- 6169 - 6183
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum der Datenerfassung
- 2021
- Titel
- Synthesis, X-ray Structure Determination, and Comprehensive Photochemical Characterization of (Trifluoromethyl)diazirine-Containing TRPML1 Ligands.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 86
Datenquelle: Europe PubMed Central
- Abstract
- Potential (trifluoromethyl)diazirine-based TRPML1 ion channel ligands were designed and synthesized, and their structures were determined by single-crystal X-ray diffraction analysis. Photoactivation studies via 19F NMR spectroscopy and HPLC-MS analysis revealed distinct kinetical characteristics in selected solvents and favorable photochemical properties in an aqueous buffer. These photoactivatable TRPML activators represent useful and valuable tools for TRPML photoaffinity labeling combined with mass spectrometry.
- Autoren
- Kevin Schwickert
- Michał Andrzejewski
- Simon Grabowsky
- Tanja Schirmeister
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/33835801
- DOI
- 10.1021/acs.joc.0c02993
- eISSN
- 1520-6904
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- J Org Chem
- Schlüsselwörter
- Diazomethane
- Ligands
- Mass Spectrometry
- Photoaffinity Labels
- X-Rays
- Sprache
- eng
- Country
- United States
- Paginierung
- 6169 - 6183
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Titel
- Synthesis, X-ray Structure Determination, and Comprehensive Photochemical Characterization of (Trifluoromethyl)diazirine-Containing TRPML1 Ligands.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 86
Datenquelle: PubMed
- Autoren
- Kevin Schwickert
- Micha L Andrzejewski
- Simon Grabowsky
- Tanja Schirmeister
- Zeitschrift
- The Journal of Organic Chemistry
- Artikelnummer
- 9
- Paginierung
- 6169 - 6183
- Datum der Veröffentlichung
- 2021
- Herausgeber
- American Chemical Society
- Datum der Datenerfassung
- 2021
- Titel
- Synthesis, X-ray Structure Determination, and Comprehensive Photochemical Characterization of (Trifluoromethyl) diazirine-Containing TRPML1 Ligands
- Sub types
- article
- Ausgabe der Zeitschrift
- 86
Datenquelle: Manual
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