Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Roberta Ettari
  • Santo Previti
  • Santina Maiorana
  • Alessandro Allegra
  • Tanja Schirmeister
  • Silvana Grasso
  • Maria Zappala
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000491239200018&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1080/14786419.2018.1483927
eISSN
1478-6427
Externe Identifier
  • Clarivate Analytics Document Solution ID: JF2TU
  • PubMed Identifier: 29897253
ISSN
1478-6419
Ausgabe der Veröffentlichung
24
Zeitschrift
NATURAL PRODUCT RESEARCH
Schlüsselwörter
  • Curcumin
  • genistein
  • rhodesain
  • drug combination studies
  • synergism
Paginierung
3577 - 3581
Datum der Veröffentlichung
2019
Status
Published
Titel
Drug combination studies of curcumin and genistein against rhodesain of <i>Trypanosoma brucei rhodesiense</i>
Sub types
  • Article
Ausgabe der Zeitschrift
33

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • Roberta Ettari
  • Santo Previti
  • Santina Maiorana
  • Alessandro Allegra
  • Tanja Schirmeister
  • Silvana Grasso
  • Maria Zappalà
DOI
10.1080/14786419.2018.1483927
eISSN
1478-6427
ISSN
1478-6419
Ausgabe der Veröffentlichung
24
Zeitschrift
Natural Product Research
Sprache
en
Online publication date
2018
Paginierung
3577 - 3581
Datum der Veröffentlichung
2019
Status
Published
Herausgeber
Informa UK Limited
Herausgeber URL
http://dx.doi.org/10.1080/14786419.2018.1483927
Datum der Datenerfassung
2020
Titel
Drug combination studies of curcumin and genistein against rhodesain of <i>Trypanosoma brucei rhodesiense</i>
Ausgabe der Zeitschrift
33

Datenquelle: Crossref

Abstract
Curcumin and genistein are two natural products obtained from <i>Curcuma longa</i> L. and soybeans, endowed with many biological properties. Within the last years they were shown to possess also a promising antitrypanosomal activity. In the present paper, we investigated the activity of both curcumin and genistein against rhodesain, the main cysteine protease of <i>Trypanosoma brucei rhodesiense</i>; drug combination studies, according to Chou and Talalay method, allowed us to demonstrate a potent synergistic effect for the combination curcumin-genistein. As a matter of fact, with our experiments we observed that the combination index of curcumin-genistein is < 1 for the reduction from 10 to 90% of rhodesain activity.
Addresses
  • Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina , Messina , Italy.
Autoren
  • Roberta Ettari
  • Santo Previti
  • Santina Maiorana
  • Alessandro Allegra
  • Tanja Schirmeister
  • Silvana Grasso
  • Maria Zappalà
DOI
10.1080/14786419.2018.1483927
eISSN
1478-6427
Externe Identifier
  • PubMed Identifier: 29897253
Funding acknowledgements
  • Research &amp; Mobility Program:
Open access
false
ISSN
1478-6419
Ausgabe der Veröffentlichung
24
Zeitschrift
Natural product research
Schlüsselwörter
  • Humans
  • Trypanosoma brucei brucei
  • Trypanosoma brucei rhodesiense
  • Curcuma
  • Curcumin
  • Genistein
  • Cysteine Endopeptidases
  • Drug Combinations
  • Trypanocidal Agents
  • Glycine max
Sprache
eng
Medium
Print-Electronic
Online publication date
2018
Paginierung
3577 - 3581
Datum der Veröffentlichung
2019
Status
Published
Datum der Datenerfassung
2018
Titel
Drug combination studies of curcumin and genistein against rhodesain of <i>Trypanosoma brucei rhodesiense</i>.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
33

Datenquelle: Europe PubMed Central

Abstract
Curcumin and genistein are two natural products obtained from Curcuma longa L. and soybeans, endowed with many biological properties. Within the last years they were shown to possess also a promising antitrypanosomal activity. In the present paper, we investigated the activity of both curcumin and genistein against rhodesain, the main cysteine protease of Trypanosoma brucei rhodesiense; drug combination studies, according to Chou and Talalay method, allowed us to demonstrate a potent synergistic effect for the combination curcumin-genistein. As a matter of fact, with our experiments we observed that the combination index of curcumin-genistein is < 1 for the reduction from 10 to 90% of rhodesain activity.
Autoren
  • Roberta Ettari
  • Santo Previti
  • Santina Maiorana
  • Alessandro Allegra
  • Tanja Schirmeister
  • Silvana Grasso
  • Maria Zappalà
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/29897253
DOI
10.1080/14786419.2018.1483927
eISSN
1478-6427
Ausgabe der Veröffentlichung
24
Zeitschrift
Nat Prod Res
Schlüsselwörter
  • Curcumin
  • drug combination studies
  • genistein
  • rhodesain
  • synergism
  • Curcuma
  • Curcumin
  • Cysteine Endopeptidases
  • Drug Combinations
  • Genistein
  • Humans
  • Glycine max
  • Trypanocidal Agents
  • Trypanosoma brucei brucei
  • Trypanosoma brucei rhodesiense
Sprache
eng
Country
England
Paginierung
3577 - 3581
Datum der Veröffentlichung
2019
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Titel
Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
33

Datenquelle: PubMed

Autoren
  • Roberta Ettari
  • Santo Previti
  • Santina Maiorana
  • Alessandro Allegra
  • Tanja Schirmeister
  • Silvana Grasso
  • Maria Zappalà
Zeitschrift
Natural product research
Artikelnummer
24
Paginierung
3577 - 3581
Datum der Veröffentlichung
2019
Herausgeber
Taylor & Francis
Datum der Datenerfassung
2021
Titel
Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense
Sub types
  • article
Ausgabe der Zeitschrift
33

Datenquelle: Manual

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