Cysteine Protease Inhibitors Containing Small Rings

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • T Schirmeister
  • A Klockow
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000210555300008&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.2174/1389557033487935
eISSN
1875-5607
Externe Identifier
  • Clarivate Analytics Document Solution ID: V56JA
  • PubMed Identifier: 12871161
ISSN
1389-5575
Ausgabe der Veröffentlichung
6
Zeitschrift
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Paginierung
585 - 596
Datum der Veröffentlichung
2003
Status
Published
Titel
Cysteine Protease Inhibitors Containing Small Rings
Sub types
  • Review
Ausgabe der Zeitschrift
3

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • T Schirmeister
  • A Klockow
DOI
10.2174/1389557033487935
ISSN
1389-5575
Ausgabe der Veröffentlichung
6
Zeitschrift
Mini-Reviews in Medicinal Chemistry
Sprache
en
Paginierung
585 - 596
Datum der Veröffentlichung
2003
Status
Published
Herausgeber
Bentham Science Publishers Ltd.
Herausgeber URL
http://dx.doi.org/10.2174/1389557033487935
Datum der Datenerfassung
2015
Titel
Cysteine Protease Inhibitors Containing Small Rings
Ausgabe der Zeitschrift
3

Datenquelle: Crossref

Abstract
Since the discovery of E-64 in 1978 as potent cysteine protease inhibitor a variety of inhibitors containing small rings as electrophilic building blocks responsible for enzyme inhibition have been developed. In this review we summarize new aspects concerning epoxysuccinyl peptides derived from E-64 and discuss inhibition potency, selectivity and mechanisms of peptidic and peptidomimetic inhibitors containing epoxide, aziridine, thiirane, cyclopropane, beta-lactam and beta-lactone rings as electrophilic fragments.
Addresses
  • Department of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany. schirmei@pharmazie.uni-wuerzburg.de
Autoren
  • T Schirmeister
  • A Klockow
DOI
10.2174/1389557033487935
eISSN
1875-5607
Externe Identifier
  • PubMed Identifier: 12871161
Open access
false
ISSN
1389-5575
Ausgabe der Veröffentlichung
6
Zeitschrift
Mini reviews in medicinal chemistry
Schlüsselwörter
  • Humans
  • Sulfides
  • Lactams
  • Epoxy Compounds
  • Cyclopropanes
  • Lactones
  • Aziridines
  • Cysteine Endopeptidases
  • Cysteine Proteinase Inhibitors
  • Structure-Activity Relationship
Sprache
eng
Medium
Print
Paginierung
585 - 596
Datum der Veröffentlichung
2003
Status
Published
Datum der Datenerfassung
2003
Titel
Cysteine protease inhibitors containing small rings.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
3

Datenquelle: Europe PubMed Central

Abstract
Since the discovery of E-64 in 1978 as potent cysteine protease inhibitor a variety of inhibitors containing small rings as electrophilic building blocks responsible for enzyme inhibition have been developed. In this review we summarize new aspects concerning epoxysuccinyl peptides derived from E-64 and discuss inhibition potency, selectivity and mechanisms of peptidic and peptidomimetic inhibitors containing epoxide, aziridine, thiirane, cyclopropane, beta-lactam and beta-lactone rings as electrophilic fragments.
Autoren
  • T Schirmeister
  • A Klockow
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/12871161
DOI
10.2174/1389557033487935
ISSN
1389-5575
Ausgabe der Veröffentlichung
6
Zeitschrift
Mini Rev Med Chem
Schlüsselwörter
  • Aziridines
  • Cyclopropanes
  • Cysteine Endopeptidases
  • Cysteine Proteinase Inhibitors
  • Epoxy Compounds
  • Humans
  • Lactams
  • Lactones
  • Structure-Activity Relationship
  • Sulfides
Sprache
eng
Country
Netherlands
Paginierung
585 - 596
Datum der Veröffentlichung
2003
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2003
Titel
Cysteine protease inhibitors containing small rings.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
3

Datenquelle: PubMed

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