(S)-thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- T Schirmeister
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000165643300015&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/S0960-894X(00)00549-7
- Externe Identifier
- Clarivate Analytics Document Solution ID: 379LJ
- PubMed Identifier: 11128643
- ISSN
- 0960-894X
- Ausgabe der Veröffentlichung
- 23
- Zeitschrift
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Paginierung
- 2647 - 2651
- Datum der Veröffentlichung
- 2000
- Status
- Published
- Titel
- (<i>S</i>)-thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors
- Sub types
- Article
- Ausgabe der Zeitschrift
- 10
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Autoren
- Tanja Schirmeister
- DOI
- 10.1016/s0960-894x(00)00549-7
- ISSN
- 0960-894X
- Ausgabe der Veröffentlichung
- 23
- Zeitschrift
- Bioorganic & Medicinal Chemistry Letters
- Sprache
- en
- Paginierung
- 2647 - 2651
- Datum der Veröffentlichung
- 2000
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/s0960-894x(00)00549-7
- Datum der Datenerfassung
- 2021
- Titel
- (S)-Thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors
- Ausgabe der Zeitschrift
- 10
Datenquelle: Crossref
- Abstract
- For (S)-thiirancarboxylic acid a second-order rate constant of k2nd = 222 M(-1) min(-1) for the irreversible inhibition of papain was determined. The ethyl and methyl ester do not inhibit the enzyme time-dependently. An improved synthesis of enantiomerically pure thiirancarboxylic acid is described. It is shown that thiirancarboxylates can be substrates for serine proteases (alpha-chymotrypsin) and esterases (pig liver esterase) and even for metallo proteases (thermolysin).
- Addresses
- Institute for Pharmacy and Food Chemistry, University of Würzburg, Germany. schirmei@pharmazie.uni-wuerzburg.de
- Autoren
- T Schirmeister
- DOI
- 10.1016/s0960-894x(00)00549-7
- eISSN
- 1464-3405
- Externe Identifier
- PubMed Identifier: 11128643
- Open access
- false
- ISSN
- 0960-894X
- Ausgabe der Veröffentlichung
- 23
- Zeitschrift
- Bioorganic & medicinal chemistry letters
- Schlüsselwörter
- Liver
- Animals
- Swine
- Carboxylic Acids
- Heterocyclic Compounds
- Esterases
- Thermolysin
- Chymotrypsin
- Cysteine Proteinase Inhibitors
- Substrate Specificity
- Sprache
- eng
- Medium
- Paginierung
- 2647 - 2651
- Datum der Veröffentlichung
- 2000
- Status
- Published
- Datum der Datenerfassung
- 2000
- Titel
- (S)-Thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 10
Datenquelle: Europe PubMed Central
- Abstract
- For (S)-thiirancarboxylic acid a second-order rate constant of k2nd = 222 M(-1) min(-1) for the irreversible inhibition of papain was determined. The ethyl and methyl ester do not inhibit the enzyme time-dependently. An improved synthesis of enantiomerically pure thiirancarboxylic acid is described. It is shown that thiirancarboxylates can be substrates for serine proteases (alpha-chymotrypsin) and esterases (pig liver esterase) and even for metallo proteases (thermolysin).
- Autoren
- T Schirmeister
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/11128643
- DOI
- 10.1016/s0960-894x(00)00549-7
- ISSN
- 0960-894X
- Ausgabe der Veröffentlichung
- 23
- Zeitschrift
- Bioorg Med Chem Lett
- Schlüsselwörter
- Animals
- Carboxylic Acids
- Chymotrypsin
- Cysteine Proteinase Inhibitors
- Esterases
- Heterocyclic Compounds
- Liver
- Substrate Specificity
- Swine
- Thermolysin
- Sprache
- eng
- Country
- England
- Paginierung
- 2647 - 2651
- PII
- S0960-894X(00)00549-7
- Datum der Veröffentlichung
- 2000
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2001
- Titel
- (S)-Thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 10
Datenquelle: PubMed
- Beziehungen:
- Eigentum von