Comparison of the separation of aziridine isomers applying heptakis(2,3-di-O-methyl-6-sulfato)β-CD and heptakis(2,3-di-O-acetyl-6-sulfato)β-CD in aqueous and nonaqueous systems

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Y Bitar
  • B Degel
  • T Schirmeister
  • U Holzgrabe
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000233189700013&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/elps.200500176
eISSN
1522-2683
Externe Identifier
  • Clarivate Analytics Document Solution ID: 982VM
  • PubMed Identifier: 16167307
ISSN
0173-0835
Ausgabe der Veröffentlichung
20
Zeitschrift
ELECTROPHORESIS
Schlüsselwörter
  • aziridines
  • cyclodextrin-modified capillary electrophoresis
  • nonaqueous capillary electrophoresis
Paginierung
3897 - 3903
Datum der Veröffentlichung
2005
Status
Published
Titel
Comparison of the separation of aziridine isomers applying <i>heptakis</i>(2,3-di-<i>O</i>-methyl-6-sulfato)β-CD and <i>heptakis</i>(2,3-di-<i>O</i>-acetyl-6-sulfato)β-CD in aqueous and nonaqueous systems
Sub types
  • Article
Ausgabe der Zeitschrift
26

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • Yaser Bitar
  • Björn Degel
  • Tanja Schirmeister
  • Ulrike Holzgrabe
DOI
10.1002/elps.200500176
eISSN
1522-2683
ISSN
0173-0835
Ausgabe der Veröffentlichung
20
Zeitschrift
ELECTROPHORESIS
Sprache
en
Paginierung
3897 - 3903
Datum der Veröffentlichung
2005
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/elps.200500176
Datum der Datenerfassung
2021
Titel
Comparison of the separation of aziridine isomers applyingheptakis(2,3-di-O-methyl-6-sulfato)β-CD andheptakis(2,3-di-O-acetyl-6-sulfato)β-CD in aqueous and nonaqueous systems
Ausgabe der Zeitschrift
26

Datenquelle: Crossref

Abstract
Aziridines are attracting interest as protease inhibitors, which might be used, e.g., for treatment of parasitic diseases. Within the framework of greater projects dealing with the search of new selective protease inhibitors, a huge number of aziridines with two stereogenic centers will be synthesized. Thus, a fast and reliable screening method for the evaluation of the isomeric composition is needed. Robust baseline separations were obtained using heptakis(2,3-di-O-acetyl-6-sulfato)beta-CD (HDAS) in acidic methanol and sulfated beta-CD in acidic phosphate buffer. With HDAS the resolutions were higher and migration times shorter. Thus, the method will be used as a screening method for further isomeric mixtures of aziridines.
Addresses
  • Institute of Pharmacy and Food Chemistry, University of Würzburg, Würzburg, Germany.
Autoren
  • Yaser Bitar
  • Björn Degel
  • Tanja Schirmeister
  • Ulrike Holzgrabe
DOI
10.1002/elps.200500176
eISSN
1522-2683
Externe Identifier
  • PubMed Identifier: 16167307
Open access
false
ISSN
0173-0835
Ausgabe der Veröffentlichung
20
Zeitschrift
Electrophoresis
Schlüsselwörter
  • Aziridines
  • Cyclodextrins
  • beta-Cyclodextrins
  • Solutions
  • Solvents
  • Stereoisomerism
Sprache
eng
Medium
Print
Paginierung
3897 - 3903
Datum der Veröffentlichung
2005
Status
Published
Datum der Datenerfassung
2005
Titel
Comparison of the separation of aziridine isomers applying heptakis(2,3-di-O-methyl-6-sulfato)beta-CD and heptakis(2,3-di-O-acetyl-6-sulfato)beta-CD in aqueous and nonaqueous systems.
Sub types
  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
26

Datenquelle: Europe PubMed Central

Abstract
Aziridines are attracting interest as protease inhibitors, which might be used, e.g., for treatment of parasitic diseases. Within the framework of greater projects dealing with the search of new selective protease inhibitors, a huge number of aziridines with two stereogenic centers will be synthesized. Thus, a fast and reliable screening method for the evaluation of the isomeric composition is needed. Robust baseline separations were obtained using heptakis(2,3-di-O-acetyl-6-sulfato)beta-CD (HDAS) in acidic methanol and sulfated beta-CD in acidic phosphate buffer. With HDAS the resolutions were higher and migration times shorter. Thus, the method will be used as a screening method for further isomeric mixtures of aziridines.
Autoren
  • Yaser Bitar
  • Björn Degel
  • Tanja Schirmeister
  • Ulrike Holzgrabe
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/16167307
DOI
10.1002/elps.200500176
ISSN
0173-0835
Ausgabe der Veröffentlichung
20
Zeitschrift
Electrophoresis
Schlüsselwörter
  • Aziridines
  • Cyclodextrins
  • Solutions
  • Solvents
  • Stereoisomerism
  • beta-Cyclodextrins
Sprache
eng
Country
Germany
Paginierung
3897 - 3903
Datum der Veröffentlichung
2005
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2006
Titel
Comparison of the separation of aziridine isomers applying heptakis(2,3-di-O-methyl-6-sulfato)beta-CD and heptakis(2,3-di-O-acetyl-6-sulfato)beta-CD in aqueous and nonaqueous systems.
Sub types
  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
26

Datenquelle: PubMed

Beziehungen:
Eigentum von

Werkzeuge