Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Marie-Adrienne Dude
  • Ulrich Kaeppler
  • Monika Herb
  • Markus Schiller
  • Franziska Schulz
  • Birgit Vedder
  • Saskia Heppner
  • Gabriele Pradel
  • Jiri Gut
  • Philip J Rosenthal
  • Tanja Schirmeister
  • Matthias Leippe
  • Christoph Gelhaus
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000262791200003&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3390/molecules14010019
Externe Identifier
  • Clarivate Analytics Document Solution ID: 399HO
  • PubMed Identifier: 19104483
ISSN
1420-3049
Ausgabe der Veröffentlichung
1
Zeitschrift
MOLECULES
Schlüsselwörter
  • Malaria
  • Cysteine protease inhibitor
  • Etacrynic acid
Paginierung
19 - 35
Datum der Veröffentlichung
2009
Status
Published
Titel
Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of <i>P</i>. <i>falciparum</i> Derived from Etacrynic Acid
Sub types
  • Article
Ausgabe der Zeitschrift
14

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Autoren
  • Marie-Adrienne Dude
  • Ulrich Kaeppler
  • Monika Herb
  • Markus Schiller
  • Franziska Schulz
  • Birgit Vedder
  • Saskia Heppner
  • Gabriele Pradel
  • Jiri Gut
  • Philip Rosenthal
  • Tanja Schirmeister
  • Matthias Leippe
  • Christoph Gelhaus
DOI
10.3390/molecules14010019
eISSN
1420-3049
Ausgabe der Veröffentlichung
1
Zeitschrift
Molecules
Sprache
en
Online publication date
2008
Paginierung
19 - 35
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/molecules14010019
Datum der Datenerfassung
2021
Titel
Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid
Ausgabe der Zeitschrift
14

Datenquelle: Crossref

Abstract
A series of etacrynic acid derivatives was synthesized and screened for their in vitro activity against Plasmodium falciparum, as well as their activity against recombinantly expressed falcipain-2 and -3. The two most active compounds of the series displayed IC(50) values of 9.0 and 18.8 microM against Plasmodia.
Addresses
  • Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, 97070 Würzburg, Germany. adrienne.dude@uni-wuerzburg.de
Autoren
  • Marie-Adrienne Dude
  • Ulrich Kaeppler
  • Monika Herb
  • Markus Schiller
  • Franziska Schulz
  • Birgit Vedder
  • Saskia Heppner
  • Gabriele Pradel
  • Jiri Gut
  • Philip J Rosenthal
  • Tanja Schirmeister
  • Matthias Leippe
  • Christoph Gelhaus
DOI
10.3390/molecules14010019
eISSN
1420-3049
Externe Identifier
  • PubMed Identifier: 19104483
  • PubMed Central ID: PMC6253875
Funding acknowledgements
  • NIAID NIH HHS: AI035800
  • NIAID NIH HHS: AI35707
Open access
true
ISSN
1420-3049
Ausgabe der Veröffentlichung
1
Zeitschrift
Molecules (Basel, Switzerland)
Schlüsselwörter
  • Animals
  • Plasmodium falciparum
  • Ethacrynic Acid
  • Cysteine Endopeptidases
  • Recombinant Proteins
  • Cysteine Proteinase Inhibitors
  • Antimalarials
  • Molecular Structure
Sprache
eng
Medium
Electronic
Online publication date
2008
Open access status
Open Access
Paginierung
19 - 35
Datum der Veröffentlichung
2008
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2008
Titel
Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
  • Research Support, N.I.H., Extramural
Ausgabe der Zeitschrift
14

Files

https://www.mdpi.com/1420-3049/14/1/19/pdf?version=1403112529 https://europepmc.org/articles/PMC6253875?pdf=render

Datenquelle: Europe PubMed Central

Abstract
A series of etacrynic acid derivatives was synthesized and screened for their in vitro activity against Plasmodium falciparum, as well as their activity against recombinantly expressed falcipain-2 and -3. The two most active compounds of the series displayed IC(50) values of 9.0 and 18.8 microM against Plasmodia.
Date of acceptance
2008
Autoren
  • Marie-Adrienne Dude
  • Ulrich Kaeppler
  • Monika Herb
  • Markus Schiller
  • Franziska Schulz
  • Birgit Vedder
  • Saskia Heppner
  • Gabriele Pradel
  • Jiri Gut
  • Philip J Rosenthal
  • Tanja Schirmeister
  • Matthias Leippe
  • Christoph Gelhaus
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/19104483
DOI
10.3390/molecules14010019
eISSN
1420-3049
Externe Identifier
  • PubMed Central ID: PMC6253875
Funding acknowledgements
  • NIAID NIH HHS: AI035800
  • NIAID NIH HHS: AI35707
Ausgabe der Veröffentlichung
1
Zeitschrift
Molecules
Schlüsselwörter
  • Animals
  • Antimalarials
  • Cysteine Endopeptidases
  • Cysteine Proteinase Inhibitors
  • Ethacrynic Acid
  • Molecular Structure
  • Plasmodium falciparum
  • Recombinant Proteins
Sprache
eng
Country
Switzerland
Paginierung
19 - 35
PII
14010019
Datum der Veröffentlichung
2008
Status
Published online
Datum, an dem der Datensatz öffentlich gemacht wurde
2009
Titel
Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid.
Sub types
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
14

Datenquelle: PubMed

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