The physiological basis for contrast opponency in motion computation in Drosophila

Publikationstyp:
Zeitschriftenaufsatz
Metadaten:
Autoren
  • Giordano Ramos-Traslosheros
  • Marion Silies
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000686662300021&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1038/s41467-021-24986-w
eISSN
2041-1723
Externe Identifier
  • Clarivate Analytics Document Solution ID: UC6VV
  • PubMed Identifier: 34404776
Ausgabe der Veröffentlichung
1
Zeitschrift
NATURE COMMUNICATIONS
Artikelnummer
ARTN 4987
Datum der Veröffentlichung
2021
Status
Published
Titel
The physiological basis for contrast opponency in motion computation in <i>Drosophila</i>
Sub types
  • Article
Ausgabe der Zeitschrift
12

Datenquelle: Web of Science (Lite)

Andere Metadatenquellen:
Abstract
<jats:title>Abstract</jats:title><jats:p>In <jats:italic>Drosophila</jats:italic>, direction-selective neurons implement a mechanism of motion computation similar to cortical neurons, using contrast-opponent receptive fields with ON and OFF subfields. It is not clear how the presynaptic circuitry of direction-selective neurons in the OFF pathway supports this computation if all major inputs are OFF-rectified neurons. Here, we reveal the biological substrate for motion computation in the OFF pathway. Three interneurons, Tm2, Tm9 and CT1, provide information about ON stimuli to the OFF direction-selective neuron T5 across its receptive field, supporting a contrast-opponent receptive field organization. Consistent with its prominent role in motion detection, variability in Tm9 receptive field properties transfers to T5, and calcium decrements in Tm9 in response to ON stimuli persist across behavioral states, while spatial tuning is sharpened by active behavior. Together, our work shows how a key neuronal computation is implemented by its constituent neuronal circuit elements to ensure direction selectivity.</jats:p>
Autoren
  • Giordano Ramos-Traslosheros
  • Marion Silies
DOI
10.1038/s41467-021-24986-w
eISSN
2041-1723
Ausgabe der Veröffentlichung
1
Zeitschrift
Nature Communications
Sprache
en
Artikelnummer
4987
Online publication date
2021
Status
Published online
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1038/s41467-021-24986-w
Datum der Datenerfassung
2022
Titel
The physiological basis for contrast opponency in motion computation in Drosophila
Ausgabe der Zeitschrift
12

Datenquelle: Crossref

Abstract
In Drosophila, direction-selective neurons implement a mechanism of motion computation similar to cortical neurons, using contrast-opponent receptive fields with ON and OFF subfields. It is not clear how the presynaptic circuitry of direction-selective neurons in the OFF pathway supports this computation if all major inputs are OFF-rectified neurons. Here, we reveal the biological substrate for motion computation in the OFF pathway. Three interneurons, Tm2, Tm9 and CT1, provide information about ON stimuli to the OFF direction-selective neuron T5 across its receptive field, supporting a contrast-opponent receptive field organization. Consistent with its prominent role in motion detection, variability in Tm9 receptive field properties transfers to T5, and calcium decrements in Tm9 in response to ON stimuli persist across behavioral states, while spatial tuning is sharpened by active behavior. Together, our work shows how a key neuronal computation is implemented by its constituent neuronal circuit elements to ensure direction selectivity.
Addresses
  • Institute of Developmental Biology and Neurobiology, Johannes-Gutenberg University Mainz, Mainz, Germany.
Autoren
  • Giordano Ramos-Traslosheros
  • Marion Silies
DOI
10.1038/s41467-021-24986-w
eISSN
2041-1723
Externe Identifier
  • PubMed Identifier: 34404776
  • PubMed Central ID: PMC8371135
Funding acknowledgements
  • European Research Council: 716512
Open access
true
ISSN
2041-1723
Ausgabe der Veröffentlichung
1
Zeitschrift
Nature communications
Schlüsselwörter
  • Neurons
  • Interneurons
  • Animals
  • Drosophila
  • Drosophila melanogaster
  • Calcium
  • Chlorphenamidine
  • Motion Perception
  • Motion
  • Female
Sprache
eng
Medium
Electronic
Online publication date
2021
Open access status
Open Access
Paginierung
4987
Datum der Veröffentlichung
2021
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2021
Titel
The physiological basis for contrast opponency in motion computation in Drosophila.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
12

Files

https://www.nature.com/articles/s41467-021-24986-w.pdf https://europepmc.org/articles/PMC8371135?pdf=render

Datenquelle: Europe PubMed Central

Abstract
In Drosophila, direction-selective neurons implement a mechanism of motion computation similar to cortical neurons, using contrast-opponent receptive fields with ON and OFF subfields. It is not clear how the presynaptic circuitry of direction-selective neurons in the OFF pathway supports this computation if all major inputs are OFF-rectified neurons. Here, we reveal the biological substrate for motion computation in the OFF pathway. Three interneurons, Tm2, Tm9 and CT1, provide information about ON stimuli to the OFF direction-selective neuron T5 across its receptive field, supporting a contrast-opponent receptive field organization. Consistent with its prominent role in motion detection, variability in Tm9 receptive field properties transfers to T5, and calcium decrements in Tm9 in response to ON stimuli persist across behavioral states, while spatial tuning is sharpened by active behavior. Together, our work shows how a key neuronal computation is implemented by its constituent neuronal circuit elements to ensure direction selectivity.
Date of acceptance
2021
Autoren
  • Giordano Ramos-Traslosheros
  • Marion Silies
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34404776
DOI
10.1038/s41467-021-24986-w
eISSN
2041-1723
Externe Identifier
  • PubMed Central ID: PMC8371135
Ausgabe der Veröffentlichung
1
Zeitschrift
Nat Commun
Schlüsselwörter
  • Animals
  • Calcium
  • Chlorphenamidine
  • Drosophila
  • Drosophila melanogaster
  • Female
  • Interneurons
  • Motion
  • Motion Perception
  • Neurons
Sprache
eng
Country
England
Paginierung
4987
PII
10.1038/s41467-021-24986-w
Datum der Veröffentlichung
2021
Status
Published online
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
The physiological basis for contrast opponency in motion computation in Drosophila.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
12

Datenquelle: PubMed

Author's licence
CC-BY
Autoren
  • Giordano Ramos-Traslosheros
  • Marion Silies
Hosting institution
Universitätsbibliothek Mainz
Sammlungen
  • JGU-Publikationen
Resource version
Published version
DOI
10.1038/s41467-021-24986-w
File(s) embargoed
false
Open access
true
ISSN
2041-1723
Zeitschrift
Nature Communications
Schlüsselwörter
  • 570 Biowissenschaften
  • 570 Life sciences
Sprache
eng
Open access status
Open Access
Paginierung
4987
Datum der Veröffentlichung
2021
Public URL
https://openscience.ub.uni-mainz.de/handle/20.500.12030/7013
Herausgeber
Nature Publishing Group UK
Datum der Datenerfassung
2022
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Zugang
Public
Titel
The physiological basis for contrast opponency in motion computation in Drosophila
Ausgabe der Zeitschrift
12

Files

the_physiological_basis_for_c-20220519111535060.pdf

Datenquelle: OPENSCIENCE.UB

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