ON selectivity in the Drosophila visual system is a multisynaptic process involving both glutamatergic and GABAergic inhibition
- Publikationstyp:
- Zeitschriftenaufsatz
- Metadaten:
-
- Autoren
- Sebastian Molina-Obando
- Juan Felipe Vargas-Fique
- Miriam Henning
- Burak Guer
- T Moritz Schladt
- Junaid Akhtar
- Thomas K Berger
- Marion Silies
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000496732500001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.7554/eLife.49373
- Externe Identifier
- Clarivate Analytics Document Solution ID: JN2LM
- PubMed Identifier: 31535971
- ISSN
- 2050-084X
- Zeitschrift
- ELIFE
- Artikelnummer
- ARTN e49373
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Titel
- ON selectivity in the <i>Drosophila</i> visual system is a multisynaptic process involving both glutamatergic and GABAergic inhibition
- Sub types
- Article
- Ausgabe der Zeitschrift
- 8
Datenquelle: Web of Science (Lite)
- Andere Metadatenquellen:
-
- Abstract
- <jats:p>Sensory systems sequentially extract increasingly complex features. ON and OFF pathways, for example, encode increases or decreases of a stimulus from a common input. This ON/OFF pathway split is thought to occur at individual synaptic connections through a sign-inverting synapse in one of the pathways. Here, we show that ON selectivity is a multisynaptic process in the Drosophila visual system. A pharmacogenetics approach demonstrates that both glutamatergic inhibition through GluClα and GABAergic inhibition through Rdl mediate ON responses. Although neurons postsynaptic to the glutamatergic ON pathway input L1 lose all responses in GluClα mutants, they are resistant to a cell-type-specific loss of GluClα. This shows that ON selectivity is distributed across multiple synapses, and raises the possibility that cell-type-specific manipulations might reveal similar strategies in other sensory systems. Thus, sensory coding is more distributed than predicted by simple circuit motifs, allowing for robust neural processing.</jats:p>
- Autoren
- Sebastian Molina-Obando
- Juan Felipe Vargas-Fique
- Miriam Henning
- Burak Gür
- T Moritz Schladt
- Junaid Akhtar
- Thomas K Berger
- Marion Silies
- DOI
- 10.7554/elife.49373
- eISSN
- 2050-084X
- Zeitschrift
- eLife
- Sprache
- en
- Online publication date
- 2019
- Status
- Published online
- Herausgeber
- eLife Sciences Publications, Ltd
- Herausgeber URL
- http://dx.doi.org/10.7554/elife.49373
- Datum der Datenerfassung
- 2023
- Titel
- ON selectivity in the Drosophila visual system is a multisynaptic process involving both glutamatergic and GABAergic inhibition
- Ausgabe der Zeitschrift
- 8
Datenquelle: Crossref
- Abstract
- Sensory systems sequentially extract increasingly complex features. ON and OFF pathways, for example, encode increases or decreases of a stimulus from a common input. This ON/OFF pathway split is thought to occur at individual synaptic connections through a sign-inverting synapse in one of the pathways. Here, we show that ON selectivity is a multisynaptic process in the <i>Drosophila</i> visual system. A pharmacogenetics approach demonstrates that both glutamatergic inhibition through GluClα and GABAergic inhibition through Rdl mediate ON responses. Although neurons postsynaptic to the glutamatergic ON pathway input L1 lose all responses in <i>GluClα</i> mutants, they are resistant to a cell-type-specific loss of <i>GluClα</i>. This shows that ON selectivity is distributed across multiple synapses, and raises the possibility that cell-type-specific manipulations might reveal similar strategies in other sensory systems. Thus, sensory coding is more distributed than predicted by simple circuit motifs, allowing for robust neural processing.
- Addresses
- Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-Universität Mainz, Mainz, Germany.
- Autoren
- Sebastian Molina-Obando
- Juan Felipe Vargas-Fique
- Miriam Henning
- Burak Gür
- T Moritz Schladt
- Junaid Akhtar
- Thomas K Berger
- Marion Silies
- DOI
- 10.7554/elife.49373
- eISSN
- 2050-084X
- Externe Identifier
- PubMed Identifier: 31535971
- PubMed Central ID: PMC6845231
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft: Emmy Noether SI 1991/1-1
- Deutsche Forschungsgemeinschaft: SFB889, Project C08
- Deutsche Forschungsgemeinschaft: SFB889
- Deutsche Forschungsgemeinschaft: Project C08
- Open access
- true
- ISSN
- 2050-084X
- Zeitschrift
- eLife
- Schlüsselwörter
- Visual Pathways
- Interneurons
- Animals
- Drosophila
- Excitatory Amino Acid Agents
- GABA Agents
- Visual Perception
- Models, Neurological
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2019
- Open access status
- Open Access
- Paginierung
- e49373
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2019
- Titel
- ON selectivity in the <i>Drosophila</i> visual system is a multisynaptic process involving both glutamatergic and GABAergic inhibition.
- Sub types
- Research Support, Non-U.S. Gov't
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 8
Files
https://europepmc.org/articles/PMC6845231?pdf=render
Datenquelle: Europe PubMed Central
- Abstract
- Sensory systems sequentially extract increasingly complex features. ON and OFF pathways, for example, encode increases or decreases of a stimulus from a common input. This ON/OFF pathway split is thought to occur at individual synaptic connections through a sign-inverting synapse in one of the pathways. Here, we show that ON selectivity is a multisynaptic process in the Drosophila visual system. A pharmacogenetics approach demonstrates that both glutamatergic inhibition through GluClα and GABAergic inhibition through Rdl mediate ON responses. Although neurons postsynaptic to the glutamatergic ON pathway input L1 lose all responses in GluClα mutants, they are resistant to a cell-type-specific loss of GluClα. This shows that ON selectivity is distributed across multiple synapses, and raises the possibility that cell-type-specific manipulations might reveal similar strategies in other sensory systems. Thus, sensory coding is more distributed than predicted by simple circuit motifs, allowing for robust neural processing.
- Date of acceptance
- 2019
- Autoren
- Sebastian Molina-Obando
- Juan Felipe Vargas-Fique
- Miriam Henning
- Burak Gür
- T Moritz Schladt
- Junaid Akhtar
- Thomas K Berger
- Marion Silies
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/31535971
- DOI
- 10.7554/eLife.49373
- eISSN
- 2050-084X
- Externe Identifier
- PubMed Central ID: PMC6845231
- Funding acknowledgements
- Deutsche Forschungsgemeinschaft: Emmy Noether SI 1991/1-1
- Deutsche Forschungsgemeinschaft: SFB889, Project C08
- Deutsche Forschungsgemeinschaft: SFB889
- Deutsche Forschungsgemeinschaft: Project C08
- Zeitschrift
- Elife
- Schlüsselwörter
- D. melanogaster
- GABAergic inhibition
- ON selectivity
- distributed coding
- feature extraction
- glutamatergic inhibition
- neuroscience
- vision
- Animals
- Drosophila
- Excitatory Amino Acid Agents
- GABA Agents
- Interneurons
- Models, Neurological
- Visual Pathways
- Visual Perception
- Sprache
- eng
- Country
- England
- PII
- 49373
- Datum der Veröffentlichung
- 2019
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Titel
- ON selectivity in the Drosophila visual system is a multisynaptic process involving both glutamatergic and GABAergic inhibition.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 8
Datenquelle: PubMed
- Beziehungen:
- Eigentum von